Article
Engineering, Biomedical
Gediminas Gaidulis, Muralidhar Padala
Summary: Surgical repair of functional mitral regurgitation (FMR) is challenging due to heterogeneity in valve geometry, and predictive models for planning this surgery are lacking. This study presents a 3D echo-derived computational model to enable subject-specific pre-surgical planning. Results show that large annuloplasty rings (>32 mm) are not effective in eliminating regurgitant gaps or restoring leaflet coaptation, while smaller rings (≤32 mm) restore better systolic valve closure but still have limitations. The study demonstrates the importance of individualized corrections and avoiding excessive annular reduction.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Gediminas Gaidulis, Kirthana Sreerangathama Suresh, Dongyang Xu, Muralidhar Padala
Summary: We developed a patient-specific computational model of the mitral valve using 3D ultrasound images to accurately simulate the pathological valve dynamics. The inclusion of patient-specific boundary conditions was found to be necessary for accurate results, and the use of idealized boundary conditions deviated from the truth dataset. Our approach of using patient-specific boundary conditions for mitral valve modeling is valid.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Cardiac & Cardiovascular Systems
Paul Wong, Andrew D. Wisneski, Amitoj Sandhu, Zhongjie Wang, Vaikom S. Mahadevan, Tom C. Nguyen, Julius M. Guccione
Summary: Severe mitral valve regurgitation (MR) can lead to congestive heart failure and death if not treated. Surgical repair or replacement of the mitral valve is currently the standard treatment, but some patients may not be eligible for surgery. Transcatheter MV repair (TMVR) is emerging as an alternative, but its long-term effectiveness and comparison to surgery are still unknown. Computational modeling using techniques like finite element method and fluid structure interactions can provide insights and help guide clinicians in choosing the optimal intervention. This review discusses the relevance of computational modeling in MV repair and its future applications in treating MR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jung-Hwan Kim, Seung Hyun Lee, Hyun-Chel Joo, Young-Nam Youn, Kyung-Jong Yoo, Byung-Chul Chang, Sak Lee
Summary: Functional mitral stenosis after mitral valve repair is associated with increased risk of new-onset atrial fibrillation, MV reoperation, and decreased long-term survival. A small left ventricle and annuloplasty ring are independent risk factors for functional MS.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Cheryl K. Zogg, Sameer A. Hirji, Edward D. Percy, Paige C. Newell, Pinak B. Shah, Tsuyoshi Kaneko
Summary: Limited data are available on the comparison of postdischarge perioperative outcomes between isolated valve-in-valve transcatheter mitral valve replacement (VIV-TMVR) and surgical reoperative mitral valve replacement (re-SMVR) on a nationwide scale. This study aimed to assess the contemporary postdischarge outcomes of VIV-TMVR and re-SMVR using a large national multicenter longitudinal database. The results showed that VIV-TMVR was associated with lower major morbidity, shorter hospital stays, and increased likelihood of discharge home compared to re-SMVR.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
James S. Gammie, Rachael W. Quinn, Erik R. Strauss, Libin Wang, Michael N. D'Ambra, Judy Hung, Daniel A. Bernstein, Douglas Tran, MaryJoe K. Rice, Sari D. Holmes, Chetan Pasrija
Summary: Mitral valve translocation effectively corrects functional (secondary) mitral regurgitation by creating a large surface of coaptation. The procedure resulted in no postoperative mortality, stroke, or renal failure, and the majority of patients had mild or less mitral regurgitation at 1 and 6 months follow-up. Further studies are needed to evaluate the long-term durability and clinical utility of this operation.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroaki Yokoyama, Tobias Friedrich Ruf, Martin Geyer, Alexander R. R. Tamm, Jaqueline Grace Da Rocha E. Silva, Theresa Ann Maria Goessler, Julia Zirbs, Ben Schwidtal, Thomas Muenzel, Ralph Stephan von Bardeleben
Summary: In this study, the effect of COMBO-TMVr on the left cardiac chambers was evaluated, including survival rate and other clinical data. The results showed that the combination therapy can support reverse remodeling of left cardiac chambers in high-risk patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dennis Rottlaeder, Martin Saal, Miriel Goedde, Alev Oeguetcue, Hubertus Degen, Michael Haude
Summary: This study investigated the effects of the Carillon device in treating functional mitral valve regurgitation, and found that in responders, there was a significant reduction in the distance between CS/Carillon device planes and the MVA plane, while in non-responders, there was an increase in angle and decrease in distance.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biophysics
G. Rossini, A. Caimi, A. Redaelli, E. Votta
Summary: A Finite Element workflow was developed for multiscale analysis of aortic valve biomechanics, capturing the impact of anatomical features on the biomechanical environment from organ to cell scale. The study found that the dependency of leaflet biomechanics on leaflet-specific anatomy observed at the organ length-scale is reflected in the results obtained at lower length-scales.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fitsum Lakew, Ayman Sodah, Michael Zacher, Gerhard Batz, Patrick Perier, Paul Urbanski, Anno Diegeler
Summary: This study evaluates the mid-term results of mitral valve repair with patch augmentation of the posterior leaflet in patients with secondary mitral regurgitation. The results show that the augmentation technique, combined with remodelling annuloplasty, is a safe and reproducible method for mitral valve reconstruction, providing sustainable competence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Karl-Andreas Dumont, Hans Martin Dahl Aguilera, Robert Persson, Victorien Prot, John-Peder Escobar Kvitting, Stig Urheim
Summary: The onset and severity of late systolic regurgitation in Barlow's mitral valve disease are determined by annulus dynamics and mechanical stresses imposed by the left ventricle. Annulus dilatation may accentuate mitral valve regurgitation, and a novel annulus elastance index can predict the severity of regurgitation.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Chetan Pasrija, Rachael W. Quinn, Daniel Bernstein, Douglas Tran, Hani Alkhatib, MaryJoe Rice, David Morales, Aakash Shah, Mehrdad Ghoreishi, Erik R. Strauss, Reney Henderson, Michael N. D'Ambra, James S. Gammie
Summary: The novel translocation repair technique effectively treats ischemic mitral regurgitation by addressing geometric alterations of the mitral valve apparatus. Compared with conventional repair, translocation creates a larger coaptation surface and preserves leaflet mobility, leading to better outcomes in treating mitral regurgitation.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Sebastien Deferm, Philippe B. Bertrand, David Verhaert, Jeroen Dauw, Jan M. Van Keer, Alexander van de Bruaene, Marie-Christine Herregods, Bart Meuris, Peter Verbrugghe, Steffen Rex, Pieter M. Vandervoort, Filip Rega
Summary: In comparing surgical outcomes and repair durability between patients with ASMR and VSMR, ASMR patients have a lower recurrence rate of moderate MR and better overall survival.
Article
Engineering, Biomedical
Harshita Narang, Bruno V. Rego, Amir H. Khalighi, Ahmed Aly, Alison M. Pouch, Robert C. Gorman, Joseph H. Gorman III, Michael S. Sacks
Summary: Research shows that there are significant differences in pre-surgical mitral valve size, shape, and deformation patterns between patients with and without IMR recurrence at 6 months post-surgery. Average pre-surgical circumferential leaflet strain in the A1 region can independently predict IMR recurrence.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Yin Ge, Sumit Gupta, Emilio Fentanes, Ayaz Aghayev, Michael Steigner, Piotr Sobieszczyk, Tsuyoshi Kaneko, Marcelo F. Di Carli, Deepak L. Bhatt, Pinak Shah, Ron Blankstein
Summary: The study found that only a minority of patients referred for TMVR planning actually underwent the procedure, with CCT technology being able to identify unsuitable anatomy and leading to exclusion in a significant number of cases.
JACC-CARDIOVASCULAR IMAGING
(2021)