Article
Public, Environmental & Occupational Health
Bashayer Ali Alshehri, Aisha M. Alamri, Ali A. Rabaan, Jaffar A. Al-Tawfiq
Summary: This study analyzed the prevalence of dermatophyte isolates in a hospital in Eastern Saudi Arabia from 2000 to 2019. Results showed that dermatophytosis was common among children and adolescents, with Microsporum and Trichophyton species decreasing significantly over time.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2021)
Article
Immunology
Arnaud Jabet, Sophie Brun, Anne-Cecile Normand, Sebastien Imbert, Mohammad Akhoundi, Eric Dannaoui, Laeticia Audiffred, Francois Chasset, Arezki Izri, Liliane Laroche, Renaud Piarroux, Claude Bachmeyer, Christophe Hennequin, Alicia Moreno Sabater
Summary: Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae was diagnosed in France. Analysis of sequences suggests that this species is widely distributed in Asia and Europe, and animals may serve as reservoirs.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Dermatology
Saham Ansari, Bahram Ahmadi, Mohammad T. Hedayati, Sadegh Nouripour-Sisakht, Mojtaba Taghizadeh-Armaki, Mobina Fathi, Niloofar Deravi, Gholam-Reza Shokoohi, Ali Rezaei-Matehkolaei
Summary: This study identified diverse ITS sequence types of T. benhamiae in different geographical regions of Iran. Terbinafine, posaconazole, and itraconazole were found to be the most effective drugs against T. benhamiae strains. Additionally, the study also described two strains of T. eriotrephon as a rare dermatophyte species.
Article
Pharmacology & Pharmacy
Fritz Ka-Ho Ho, Albert Bolhuis, M. Begona Delgado-Charro
Summary: The study tested the use of polymeric films sprayed on the skin for the prevention and treatment of dermatophytosis, showing that the films can both prevent and treat fungal infections, and are generally acceptable for use by healthy volunteers.
Article
Microbiology
Cecile Le Barzic, Adela Cmokova, Chloe Denaes, Pascal Arne, Vit Hubka, Jacques Guillot, Veronica Risco-Castillo
Summary: This study evaluated the frequency of dermatophyte detection in hedgehogs at a wildlife rehabilitation center near Paris, finding that over a quarter of samples tested positive. Treatment required several months, but dermatophytosis did not seem to reduce the probability of hedgehogs being released.
Article
Education & Educational Research
Edid Tatiana Mejia Alvarez, Paola Estefania Guerrero Moran
Summary: This research study aimed to design strategies for preventing risk factors of dermatophytosis in children. The methodology used was mixed qualitative-quantitative, and the findings highlighted several insufficiencies in the prevention of these risk factors. Based on these findings, educational strategies were proposed for the adequate prevention of these skin diseases.
Article
Mycology
Saham Ansari, Bahram Ahmadi, Seyedeh Nadia Tabatabaeifar, Mohammad T. Hedayati, Javad Javidnia, Mojtaba Taghizadeh Armaki, Gholam Reza Shokoohi, Ali Rezaei-Matehkolaei
Summary: In this study, we report a case of tinea faciei and tinea corporis transmitted from a guinea pig to a 12-year-old girl and her 53-year-old father in Iran, successfully treated with 2% topical sertaconazole nitrate cream for 4 weeks.
Article
Biochemistry & Molecular Biology
Basem M. M. Abdallah, Peramaiyan Rajendran, Enas M. M. Ali
Summary: In this study, green synthesized silver nanoparticles (AS-AgNPs) using Achillea santolina extract were found to have anti-dermatophytic potential against Trichophyton rubrum. AS-AgNPs inhibited the growth of T. rubrum, suppressed conidial germination and hyphal growth, and caused structural and membrane damage. Moreover, AS-AgNPs reduced cell wall integrity and inflammatory response. Overall, AS-AgNPs represent a novel green topical therapy for T. rubrum dermatophytosis.
Article
Dermatology
Kristoffer Nagy Skaastrup, Karen Marie Thyssen Astvad, Maiken Cavling Arendrup, Gregor Borut Ernst Jemec, Ditte Marie Lindhardt Saunte
Summary: Soaking sock pieces in a QAC-detergent for 24 hours effectively disinfects them from terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp. Freezing and steam washing methods did not show any disinfectant properties.
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Mycology
Chao Tang, Xue Kong, Sarah A. Ahmed, Rameshwari Thakur, Anuradha Chowdhary, Pietro Nenoff, Silke Uhrlass, Shyam B. Verma, Jacques F. Meis, Hazal Kandemir, Yingqian Kang, G. Sybren de Hoog
Summary: In India, a severe outbreak of highly virulent and multi-resistant dermatophytosis by species in the Trichophyton mentagrophytes/T. interdigitale complex is ongoing, and the accurate identification of the etiologic agent is a debated issue. Molecular, morphological, and physiological characteristics were used in a taxonomic study to define species limits. The study found that while T. mentagrophytes s. str. and T. interdigitale s. str. are difficult to distinguish, they are different from the Indian genotype T. indotineae in the HMG gene sequence. These characteristics may be driving separate evolutionary trends.
Article
Pharmacology & Pharmacy
Koushlesh K. Mishra, Chanchal D. Kaur, Anshita Gupta
Summary: This study developed and optimized transethosomes (TEs) loaded with Itraconazole (ICZ) for topical application. The ICZ-loaded TEs demonstrated good physical properties, sustained drug release and permeation, and potential antifungal activity against Trichophyton species. The results suggest that the ICZ-loaded TEs gel could be a better alternative than marketed formulations for the treatment of Trichophyton skin infections, pending future clinical studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Mycology
Xiu-Jiao Xia, Hong Shen, Hui-Lin Zhi, Yan Zhong, Bo Sang, Wen-Wen Lv, Qiu-Ping Li, Ze-Hu Liu
Summary: Deep cutaneous fungal infections, such as deep dermatophytosis, can cause significant morbidity and mortality, particularly in immunocompromised patients. The use of direct microscopy for rapid bedside diagnosis of disseminated deep dermatophytosis has shown promising results. Purulence sampling and direct microscopy can facilitate early diagnosis and prevent disease progression.
Editorial Material
Immunology
Nivedita Sriram, Audrey Rutherford, Ricardo La Hoz, Cristina Thomas
Summary: Deep dermatophytosis is a rare fungal infection that primarily affects the dermis in individuals with compromised immune function. We present a case of trichophyton deep dermatophytosis in a patient with a history of orthotopic heart transplantation, presenting with superficial white onychomycosis and papules and plaques on the legs.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Immunology
Jingwen Tan, Qian Yu, Zhiqin Gao, Hong Yang, Qilong Chen, Lianjuan Yang
Summary: This article reports a case of deep dermatophytosis in a patient with a novel mutation in the CARD9 gene, which led to severe and intractable symptoms. The patient was ultimately alleviated by treatment with posaconazole.
FRONTIERS IN IMMUNOLOGY
(2022)
