Article
Dermatology
Chisato Yahiro, Toshihiro Takai, Shoko Nakatani, Nanako Tanaka, Aya Goto
Summary: Combination therapy with immune checkpoint inhibitors and cytotoxic anticancer drugs can cause more frequent and severe skin rashes compared to monotherapy. This study aimed to describe the experience of skin rashes in 11 patients who received combination therapy with immune checkpoint inhibitors and cytotoxic drugs within 2 weeks.
JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Luke Ardolino, Brandon Lau, Isabella Wilson, Julia Chen, Linda Borella, Emily Stone, Elgene Lim
Summary: Taxane-induced pneumonitis (TIP) is rarely seen in patients with early breast cancer, but remains under-described. A study at an Australian institution identified 6 cases of TIP among 132 patients treated with a paclitaxel-containing regimen. The review outlines presentation, management, outcomes, and proposes an approach to suspected TIP in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesca Barbin, Michele Ghidini, Alessandra Panichi, Gianluca Tomasello, Claudia Bareggi, Barbara Galassi, Nerina Denaro, Fiorella Ruatta, Carolina Cauchi, Maria Grazia Rossino, Ornella Garrone
Summary: Oxaliplatin-based chemotherapy is commonly used for gastrointestinal tumors and other malignancies, with allergic reactions being a common occurrence. While no definitive approach has been found to reduce the risk of reactions, stronger premedication and extending infusion time may help in minimizing the severity of reactions.
Article
Pathology
Giovanni Zarrilli, Valentina Angerilli, Rocco Cappellesso, Francesca Galuppini, Gianmaria Pennelli, Fabio Farinati, Lorenzo Nicole, Edoardo Savarino, Stefano Realdon, Gaia Griguolo, Michele Bottosso, Maria Vittoria Dieci, Valentina Guarneri, Angelo Paolo Dei Tos, Marcello Lo Mele, Matteo Fassan
Summary: The metastatic spread of breast carcinoma to the stomach is rare and often poses a diagnostic challenge. This study retrospectively identified 23 cases of gastric metastases from breast cancer and analyzed their histotype, localization, appearance, and architecture. The findings suggest that immunohistochemistry, specifically a panel of cytokeratins 7 and 20, Estrogen and Progesteron Receptors, can significantly improve diagnostic accuracy.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Dermatology
Nanako Tanaka, Shoko Nakatani, Chisato Yahiro, Toshihiro Takai
Summary: Radiation dermatitis is the most common adverse reaction of radiotherapy, and there have been reports of erythema multiforme-like rash associated with radiotherapy. We aimed to evaluate the potential association between radiotherapy and erythema multiforme-like rash in a larger sample of patients. Our study included 30 patients who developed erythema multiforme-like rash during or after radiotherapy, and in most cases, the rash was relieved by conservative management and radiotherapy could be continued. Radiotherapy should be considered as a potential trigger for erythema multiforme-like rash in cancer patients.
JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Eleni Zografos, Anna-Maria Korakiti, Angeliki Andrikopoulou, Ioannis Rellias, Constantine Dimitrakakis, Spyridon Marinopoulos, Aris Giannos, Antonios Keramopoulos, Nikolaos Bredakis, Meletios-Athanasios Dimopoulos, Flora Zagouri
Summary: This study analyzed the frequency of genetic predisposition in 20 PABC patients, revealing that 35% of patients carried pathogenic mutations in two known cancer predisposition genes (BRCA1 and CHEK2), indicating a potential significant role of genetic susceptibility in pregnancy-associated breast cancer.
Article
Oncology
Claudia Giani, Stefano Radaelli, Rosalba Miceli, Lorenza Gandola, Claudia Sangalli, Anna Maria Frezza, Salvatore Provenzano, Sandro Pasquali, Rossella Bertulli, Marco Fiore, Dario Callegaro, Michela Casanova, Stefano Chiaravalli, Paola Collini, Gian Paolo Dagrada, Carlo Morosi, Nadia Zaffaroni, Paolo G. Casali, Andrea Ferrari, Alessandro Gronchi, Silvia Stacchiotti
Summary: A retrospective study on primary DSRCT was conducted to characterize long-term survivors (LTS). It was found that 13% of patients achieved cure, who had no liver or extra-abdominal metastasis at diagnosis, received complete surgery, and possibly underwent whole abdomino-pelvic radiotherapy (WAP-RT) and maintenance chemotherapy (MC).
Article
Biochemistry & Molecular Biology
Megan Parker, Anita Kalluri, Joshua Materi, Sachin K. Gujar, Karisa Schreck, Debraj Mukherjee, Jon Weingart, Henry Brem, Kristin J. Redmond, Calixto-Hope G. Lucas, Chetan Bettegowda, Jordina Rincon-Torroella
Summary: This article presents a case series of nine patients with intraventricular glioblastoma (IVGBM) and explores the molecular alterations found in these rare tumors. Further studies are needed to understand the genetic landscape and unique pathophysiology of IVGBM compared to parenchymal glioblastoma. Prompt intervention is necessary for the management of IVGBM due to their anatomical location, presentation with obstructive hydrocephalus, and fast growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Developmental
Hannah Lonsdale, Kathryn M. Kimsey, Jerry M. Brown, Aditi Dey, Jacquelin Peck, Sorany Son, Michael Wilsey
Summary: This study reported a case series of adolescent patients with Cannabis Hyperemesis (CH) over 10 years, showing similar clinical manifestations to adult CH patients, limited treatment efficacy, and the need for further research to confirm the incidence, symptom features, and treatment effectiveness.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Oncology
Akemi Kataoka, Takayuki Ueno, Hideko Yamauchi, Natsue Uehiro, Chikako Takahata, Yoko Takahashi, Eri Nakashima, Akiko Ogiya, Takehiko Sakai, Dai Kitagawa, Hidetomo Morizono, Yumi Miyagi, Takuji Iwase, Atsuko Kitano, Yumi Fukatsu, Nobuko Tamura, Junko Kawano, Hiroko Bando, Kentaro Tamaki, Kyoko Shiota, Miwa Ozawa, Mariko Kobayashi, Shinji Ohno
Summary: The purpose of this study was to clarify the characteristics, treatment trends, and long-term outcomes of patients with pregnancy-associated breast cancer (PABC). The results showed that patients with breast cancer diagnosed within 1 year after childbirth or during lactation (LBC) had poorer prognosis than patients with breast cancer diagnosed during pregnancy (PBC). It was found that early detection and optimization of systemic treatments are critical for improving the outcomes of patients with LBC.
Article
Clinical Neurology
Shami Acharya, Jose Pedro Lavrador, Priya Pavninder Sekhon, Ravindran Visagan, Josephine Jung, Richard Gullan, Francesco Vergani, Ranjeev Bhangoo, Keyoumars Ashkan
Summary: The study observed that the management approach for patients with low-grade gliomas has evolved over the past decade, showing a shift towards more radical surgical procedures associated with improved survival rates, reduced need for postoperative adjuvant therapy, and better seizure control.
WORLD NEUROSURGERY
(2021)
Article
Rheumatology
Hyunsue Do, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study investigated the frequency, types, and temporal relationship of cancer-associated vasculitis in Korean patients. The study found that the frequency of cancer-associated vasculitis was 0.034%, with thyroid cancer being the most common type of cancer and Behcet disease being the most frequent type of vasculitis associated with cancer.
CLINICAL RHEUMATOLOGY
(2023)
Article
Oncology
Elizabeth M. Gaughan, Bethany J. Horton
Summary: The study found that receiving chemotherapy after immunotherapy for metastatic melanoma did not significantly improve outcomes, but it may still provide palliative benefits for some patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Frederic Amant, Valentina Nekljudova, Charlotte Maggen, Fenja Seither, Patrick Neven, Elyce H. Cardonick, Sabine Schmatloch, Kristel Van Calsteren, Tatjana Cordes, Jorine de Haan, Christianne A. R. Lok, Felix Flock, Ingrid A. Boere, Mina M. Gziri, Christine Solbach, Hanne Lefrere, Andreas Schneeweiss, Isabell Witzel, Sabine Seiler, Sibylle Loibl
Summary: The survival of breast cancer patients undergoing chemotherapy during pregnancy is comparable to that of young non-pregnant patients, indicating the efficacy of chemotherapy for PrBC when necessary.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Sarah Asad, Carlos H. Barcenas, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Ellis G. Levine, Nancy U. Lin, Beverly Moy, Joyce Niland, Antonio C. Wolff, Michael J. Hassett, Daniel G. Stover
Summary: The study aimed to evaluate clinicopathologic and sociodemographic features associated with rapid-relapse TNBC, showing that factors such as disease stage, insurance type, income, and age were significantly associated with rapid-relapse TNBC. These factors had different impacts on patients with stage I/II disease compared to those with stage III disease, emphasizing the importance of considering sociodemographic factors in TNBC relapse timing.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)