Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Article
Biochemistry & Molecular Biology
Linzehao Li, Qinghe Song, Xiandang Zhang, Yan Yan, Xiaolei Wang
Summary: The study aimed to investigate the association between allicin treatment of diabetes and Advanced Glycation End products (AGEs). The results showed that allicin can alleviate diabetes by inhibiting AGE formation, reducing RAGE levels, relieving oxidative stress, and promoting insulin secretion.
Review
Food Science & Technology
Lezhen Dong, Ying Li, Qin Chen, Yahui Liu, Zufang Wu, Daodong Pan, Ning Yan, Lianliang Liu
Summary: Advanced glycation end products (AGEs), the products of non-enzymatic browning reactions between reducing sugars and amino acids, are oxidative derivatives resulting from diabetic hyperglycemia and pose a risk for insulin resistance (IR) and type 2 diabetes (T2D). Accumulation of AGEs triggers negative effects such as oxidative stress, inflammation, and gut microbiota imbalance. Recent studies show that cereal polyphenols can inhibit AGEs formation and alleviate T2D. This review highlights the effects of cereal polyphenols in anti-AGEs and T2D treatment, providing new insights into diabetes etiology and treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Food Science & Technology
Runlin Wu, Caihua Jia, Jianhua Rong, Shanbai Xiong, Ru Liu
Summary: This study investigates the effects of different pretreatment methods on the formation of advanced glycation end products (AGEs) in fried shrimp. The results show that pretreatment methods can control the Maillard and oxidation reactions by altering the basic compositions, thus affecting the formation of AGEs. The batter-coated treatment can reduce the AGEs content but increase the oil content. Lipid oxidation is a crucial reaction in the formation of AGEs. Furthermore, whole shrimp is the best choice for producing fried shrimp with low AGEs content and desirable color.
Article
Chemistry, Applied
Ting Li, Lihong Niu, Xianghong Li, Faxiang Wang, Yiqun Huang, Yongle Liu
Summary: Lipid oxidation, protein degradation, and AGEs formation increased during freezing-thawing cycles and heat treatment. Freezing-thawing treatment accelerated the heat-induced increase of AGEs in surimi products. Correlation analysis showed that lipid oxidation and protein degradation promoted the chemical synthesis of AGEs, while Schiff base oxidation likely occurred only under thermal treatment.
Article
Food Science & Technology
Mengna Zhao, Ying Li, Xue Bai, Jia Feng, Xiufang Xia, Fangfei Li
Summary: The inhibitory effect of guava leaf polyphenols (GLP) on the formation of advanced glycation end products (AGEs) in frozen chicken meatballs was investigated. The GLP effectively reduced the levels of various AGEs, such as glyoxal (GO), N-epsilon-carboxymethyl-lysine (CML), pentosidine, and fluorescent AGEs, by inhibiting lipid oxidation, protein oxidation, and Maillard reaction. The possible mechanisms of inhibition included scavenging free radicals, capturing dicarbonyl compounds, forming polyphenol-protein compounds, and reducing glucose formation.
Article
Food Science & Technology
Yong Li, Hua Li, Yinchun Zhu, Cuiping Feng, Zhiyong He, Jie Chen, Maomao Zeng
Summary: This study evaluated the relationship between the different processing stages of cooked sausage preparation and the formation of advanced glycation end products, dicarbonyl compounds, and lipid and protein oxidation. Baking and steaming promoted lipid and protein oxidation, while chili and garlic increased the formation of advanced glycation end products. Black pepper had an impact on the formation of advanced glycation end products during the steaming stage.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Haonan Shi, Ruike Qin, Runlin Wu, Jianhua Rong, Caihua Jia, Ru Liu
Summary: The study investigated the effects of different cryoprotectants on the formation of advanced glycation end products and acrylamide in fried fish cakes. Sorbitol significantly reduced AA and fluorescent AGE contents, while polyphosphates reduced CML and fluorescent AGE but increased AA. A combination of cryoprotectants led to the highest CML content, suggesting that certain combinations should be avoided in fried surimi products.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Cell Biology
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri
Summary: Insulin resistance is commonly observed during aging and is a major factor in chronic nontransmissible diseases. Diet, particularly the intake of advanced glycation end products (AGEs), plays a significant role in causing insulin resistance. Clinical trials and animal studies suggest that reducing dietary AGE intake can improve insulin resistance.
Article
Food Science & Technology
Lihong Niu, Keqiang Lai, Yiqun Huang
Summary: This research aimed to investigate the effects of sodium chloride on the formation of N epsilon-carboxymethyllysine and N epsilon-carboxyethyllysine in pork myofibrillar protein systems during commercial sterilization. The results showed that the addition of NaCl reduced the heat-induced production of CML and CEL. Additionally, the presence of NaCl altered the promoting effect of lipid oxidation on the formation of advanced glycation end-products in protein-reducing sugar systems.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Food Science & Technology
Rui Fang, Zongshuai Zhu, Anthony Pius Bassey, Iftikhar Ali Khan, Ming Huang
Summary: This study investigated the effects of GO on emulsifying properties, rheological behavior, and AGE formation in CME, finding that GO played a major role in the formation of AGE in CME, with a greater impact compared to oxidation.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Nutrition & Dietetics
Isaac Ampong, Adam Watkins, Jorge Gutierrez-Merino, John Ikwuobe, Helen R. Griffiths
BRITISH JOURNAL OF NUTRITION
(2020)
Review
Pharmacology & Pharmacy
Lorena Diaz Sanchez, Lorenzo Pontini, Maura Marinozzi, Lissette Carolina Sanchez-Aranguren, Ana Reis, Irundika H. K. Dias
Summary: Cholesterol and oxysterol sulfates play crucial roles in lipid metabolism, inflammation, cell apoptosis, and survival. However, further research is needed to analyze and understand the physiological and pathophysiological roles of oxysterol sulfates.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Lissette Sanchez-Aranguren, Irundika H. K. Dias, Swati Agrawal, Anna Sparatore, Keqing Wang, Asif Ahmed
Summary: Preeclampsia is a common and serious complication affecting millions of pregnant women worldwide. This study found that a novel H2S-releasing aspirin can ameliorate preeclampsia by reducing hypertension and renal damage through possibly stimulating antioxidant genes, improving fetal outcomes compared to aspirin alone.
Article
Dentistry, Oral Surgery & Medicine
Praveen Sharma, Anthony Fenton, Irundika H. K. Dias, Brenda Heaton, Caroline L. R. Brown, Amneet Sidhu, Mutahir Rahman, Helen R. Griffiths, Paul Cockwell, Charles J. Ferro, Iain L. Chapple, Thomas Dietrich
Summary: The study found a causal relationship between periodontal inflammation and renal function, mediated by systemic oxidative stress. Periodontal inflammation represents an occult source of oxidative stress in patients with CKD, and periodontal therapy may potentially improve outcomes in CKD by reducing systemic inflammatory/oxidative stress burden.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Editorial Material
Neurosciences
Irundika H. K. Dias, Helen R. Griffiths
Summary: Neuroinflammation is implicated in Alzheimer's disease, with deficits in anti-inflammatory/resolution pathways potentially leading to chronic inflammation. Understanding lipid signaling in inflammation resolution may lead to the development of new therapeutic agents for AD prevention studies.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
IrundikaH K. Dias, Rachelle Taiwo, Dan Ma
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hala Shokr, Irundika H. K. Dias, Doina Gherghel
Summary: The study found that oxysterol levels are related to retinal microvascular function, and abnormal levels of oxysterols may indicate early risk for cardiovascular diseases as individuals age.
Article
Neurosciences
Irundika H. K. Dias, Hala Shokr, Freya Shephard, Lisa Chakrabarti
Summary: This study found that the metabolism of oxysterols is altered in the brain of Alzheimer's disease (AD) patients, leading to increased synthesis of 26-OHC, 25-OHC, and 7-oxocholesterol, and decreased levels of oxysterol sulfates. This may affect brain mitochondrial function and contribute to the progression of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cell Biology
Hala Shokr, Victoria Lush, Irundika Hk Dias, Aniko Ekart, Gustavo De Moraes, Doina Gherghel
Summary: Ageing is a major risk factor for diseases like cardiovascular diseases, and finding effective measurements of biological ageing is an ongoing quest. This study found that using retinal microvascular function alone or in combination with telomere length can predict age and blood pressure, especially in younger individuals.
Article
Biology
Hannah L. Morgan, Samuel Furse, Irundika H. K. Dias, Kiran Shabir, Marcos Castellanos, Iqbal Khan, Sean T. May, Nadine Holmes, Matthew Carlile, Fei Sang, Victoria Wright, Albert Koulman, Adam J. Watkins
Summary: This study reveals that a poor paternal diet can negatively impact the metabolic homeostasis of offspring, and these effects are still evident in the second generation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Reis, Sara Rocha, Irundika H. K. Dias, Raquel Costa, Raquel Soares, Jose Luis Sanchez-Quesada, Antonio Perez, Victor de Freitas
Summary: The incidence of diabetes has tripled globally in the past 5 decades. Nutritional strategies provide valuable alternatives to prevent and manage diabetes, and can contribute to the sustainability of health budgets. This study investigates the impact of type 2 diabetes on the transport and delivery of bioactive plant-based compounds through triglyceride-rich lipoproteins, highlighting the relevance of nutritional guidelines as an alternative strategy to drug-based therapies.
Article
Biochemistry & Molecular Biology
Megan A. Palmer, Irundika H. K. Dias, Eleanor Smart, Yvonne Benatzy, Iain S. Haslam
Summary: The importance of cholesterol in hair follicle biology is highlighted by its connection to alopecias and hair growth disorders. ABCA5 defects have been linked to altered keratinocyte cholesterol distribution in individuals with a specific type of congenital hypertrichosis, but the underlying biological mechanism for this hair growth defect remains unknown. This study aimed to investigate the impact of ABCA5 activity on hair follicle keratinocyte behavior and found that ABCA5 plays a role in the intracellular compartmentalization of free cholesterol in primary hair follicle keratinocytes. The loss of ABCA5 could lead to impaired endo-lysosomal cholesterol transport, which may affect pathways known to influence hair growth, highlighting the need for further research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Busra Kose, Irundika Dias, Serkan Erkanli, Alper Kocak, Ahmet Tarik Baykal
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Guerman Molostvov, Mariam Gachechiladze, Abeer M. Shaaban, Steven Hayward, Isaac Dean, Irundika H. K. Dias, Nahla Badr, Irini Danial, Fiyaz Mohammed, Vera Novitskaya, Liliia Paniushkina, Valerie Speirs, Andrew Hanby, Irina Nazarenko, David R. Withers, Steven van Laere, Heather M. Long, Fedor Berditchevski
Summary: The immune microenvironment in breast cancer is regulated by cancer cell-derived extracellular vesicles, which control the recruitment and accumulation of B lymphocytes. The Liver X receptor (LXR)-dependent transcriptional network and the tetraspanin 6 (Tspan6) play key roles in this process by regulating the accumulation of oxysterol ligands in extracellular vesicles.
Article
Biochemistry & Molecular Biology
Lorena Diaz Sanchez, Lissette Sanchez-Aranguren, Keqing Wang, Corinne M. Spickett, Helen R. Griffiths, Irundika H. K. Dias
Summary: Endothelial dysfunction is associated with cardiovascular complications and hydrogen sulfide (H2S) has shown beneficial effects on the vasculature through anti-inflammatory and redox-modulating mechanisms. This study investigates the link between H2S and mitochondrial health in endothelial cells and the mechanisms by which H2S rescues apoptosis. The results demonstrate that TNF-alpha-induced endothelial dysfunction leads to oxidative stress, apoptosis, and mitochondrial alterations, which can be alleviated by post-treatment with the slow-releasing H2S donor, GYY4137.
