Review
Biochemistry & Molecular Biology
In-Ho Seo, Yong-Jae Lee
Summary: Complete blood count is a commonly requested blood test that evaluates the characteristics and total numbers of cell components in the blood. Recent investigations have shown that the components of complete blood count can be used to predict the risk of cardiovascular disease and metabolic disorders.
Article
Fisheries
HyeJin Jeong, Minji Kang, Sun-Yeong Cha, Jihyun Byun, Jieun Kim, Jeong Won Baek, Jung Jun Park, So Ryung Shin, Hyeon Jin Kim, Jung Sick Lee, Yun Kyung Shin, Yong-Pil Cheon
Summary: The study investigated the relationship between temperature and sensitivity levels of blood biochemical markers in red sea bream. The results showed that certain physiological diagnostic biomarkers exhibit temperature-specific blood levels and are more sensitive to acclimated temperature. These markers can be classified into four clusters, with some being more useful for evaluating stress or stressors in red sea bream health and environmental monitoring programs.
Article
Dentistry, Oral Surgery & Medicine
Chi-Ching Chang, Sung K. Kim, Chun-Teh Lee
Summary: This study compared the 3D volumetric changes of peri-implant bone at immediate implant sites with 2D linear measurements. The results showed that linear measurements could not fully represent volumetric bone dimensional changes. Volumetric measurements and 3D rendering were valuable in presenting the actual amount and topography of peri-implant bone remodeling.
JOURNAL OF DENTISTRY
(2022)
Review
Hematology
James I. Hearn, Elizabeth E. Gardiner
Summary: This article discusses the role of platelets in the formation of a hemostatic response and vascular injury repair, as well as their function in flowing blood. The article highlights the importance of platelet adhesion and activation in forming and strengthening adhesive ties, and discusses the challenges faced in research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Environmental Sciences
Esther Descalzo, Pablo R. Camarero, Ines S. Sanchez-Barbudo, Monica Martinez-Haro, Manuel E. Ortiz-Santaliestra, Ruben Moreno-Opo, Rafael Mateo
Summary: The study revealed that lead poisoning is a significant cause of death and sublethal effects on haem biosynthesis, P metabolism, and oxidative stress in birds of prey in Spain, with abnormal levels of lead found in blood and liver, along with negative impacts on biological metabolism, oxidative stress, and immune function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Stepan Podzimek, Lucie Himmlova, Tatjana Janatova, Geir Bjorklund, Radka Vrbova, Marketa Janovska, Massimiliano Peana, Christos T. Chasapis, Alex Vinsu, Jarmila Prochazkova, Jana Duskova
Summary: This study found a correlation between metal hypersensitivity and failed orthopedic implants. Metal hypersensitivity testing should be conducted on patients undergoing orthopedic implant surgery to minimize the risk of implant failure.
CLINICAL IMMUNOLOGY
(2022)
Review
Orthopedics
Sravya P. Vajapey, Vivek M. Shah, Daniel M. Estok
Summary: Trunnion in total hip arthroplasty is the interface between the neck of a femoral stem and the femoral head. Complications arising from damage to this junction, known as MACC or trunnionosis, have increased with the use of modular hip prostheses. Factors such as taper design, implant metallurgical properties, and size mismatch of the bearing couple contribute to this condition.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Peripheral Vascular Disease
Fang-Fei Wei, Yuanyuan Zhou, Yuzhong Wu, Xuwei Chen, Jiangui He, Yugang Dong, Jan A. Staessen, Chen Liu
Summary: The study found that cumulative blood pressure exposure is associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Longitudinal blood pressure measurements may help refine risk stratification for patients with HFpEF.
HYPERTENSION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mette Holm Hjorth, Inger Mechlenburg, Frederik Nicolai Foldager, Marianne Tjur, Maiken Stilling
Summary: The study compared muscle mass, power, step test asymmetry, and patient-reported outcomes between MoM THA/HRA and MoP THA, finding no significant differences in functional outcomes.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Jessilyn Dunn, Lukasz Kidzinski, Ryan Runge, Daniel Witt, Jennifer L. Hicks, Sophia Miryam Schussler-Fiorenza Rose, Xiao Li, Amir Bahmani, Scott L. Delp, Trevor Hastie, Michael P. Snyder
Summary: Data collected from wearable devices can predict clinical laboratory measurements more accurately than clinically obtained vital sign measurements, demonstrating the potential value of commercial wearable devices in assessing physiological measurements and potentially replacing some laboratory tests.
Article
Orthopedics
Sakari Pietilainen, Erno Smedberg, Inari Laaksonen, Mikko S. Venalainen, Petteri Lankinen, Keijo T. Makela
Summary: The study found that metal ion levels in the blood of metal-on-metal total hip arthroplasty patients may change over time, but the clinical outcomes remain relatively stable. Despite this, continued follow-up of these devices is recommended due to the relatively low implant survival rates.
Article
Peripheral Vascular Disease
Fang-Fei Wei, Yuanyuan Zhou, Lutgarde Thijs, Ruicong Xue, Bin Dong, Xin He, Weihao Liang, Yuzhong Wu, Jingzhou Jiang, Weiping Tan, Jiangui He, Jan A. Staessen, Yugang Dong, Jingjing Zhao, Chen Liu
Summary: In patients with heart failure with preserved ejection fraction, greater systolic and diastolic blood pressure variability is associated with adverse health outcomes independent of blood pressure level. Sensitivity analyses stratified by sex, age, and region confirmed these associations.
Article
Orthopedics
Graham R. Hastie, Sophie C. Collinson, Adeel Aqil, Subhasis Basu, David E. Temperley, Timothy N. Board, Henry Wynn-Jones
Summary: This study reported on the incidence of adverse reactions to metal debris following Hip Resurfacing (HR) with a minimum follow-up of 13 years. The results showed a high incidence of ARMD, highlighting the importance of awareness and long-term screening for both surgeons and patients. Efforts should be made to inform individuals about potential risks and the best implant choices for their personal requirements.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Medicine, General & Internal
Fabio Mancino, Michael A. Finsterwald, Christopher W. Jones, Gareth H. Prosser, Piers J. Yates
Summary: This study aims to provide an updated analysis of the long-term outcomes and metal ion levels of patients with metal-on-metal hip resurfacing (HR) and large-diameter-head (LDH) total hip arthroplasty (THA). The results showed no significant differences in clinical outcomes between the two groups, but the HR group had significantly lower metal ion levels compared with the modular THA group. Both implants demonstrated excellent survivorship, with the Adept HR showing remarkable reliability in young active males. The modular LDH THA, despite being discontinued, exhibited higher reliability and lower failure rate compared to similar withdrawn MoM implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Reza Soleimani, Mehdi Khourssaji, Damien Gruson, Hector Rodriguez-Villalobos, Mathilde Berghmans, Leila Belkhir, Jean-Cyr Yombi, Benoit Kabamba-Mukadi
Summary: Since the outbreak of COVID-19, the global battle against SARS-CoV-2 has been ongoing. Studies have shown that combining antibody and nucleic acid detection can increase the diagnostic sensitivity of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Correction
Orthopedics
Arianna Cerquiglini, Johann Henckel, Harry Hothi, Lukas B. Moser, Antti Eskelinen, Michael T. Hirschmann, Alister J. Hart
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Health Care Sciences & Services
Ilona Swiatkowska, Johann Henckel, Shiraz A. Sabah, Alister J. Hart
Summary: This study investigated the prevalence of self-reported neurotoxicity and cognitive defects in hip replacement patients with markedly raised blood cobalt. The results showed that the frequency of reporting symptoms was significantly higher in patients with metal-on-metal implants, but clinically significant neurotoxicity was not observed.
JOURNAL OF PATIENT SAFETY
(2022)
Correction
Orthopedics
Michael T. Hirschmann, Alister Hart, Johann Henckel, Patrick Sadoghi, Romain Seil, Caroline Mouton
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Kevin C. Ilo, Harry S. Hothi, John A. Skinner, Alister J. Hart
Summary: This study compared different modular metal-on-metal implants from the same manufacturer and found that modular implants had a higher incidence of adverse local tissue reaction, which may be related to the modular junctions, especially the neck-stem junction, which was more susceptible to corrosion.
Article
Orthopedics
Laura M. Horga, Johann Henckel, Anastasia Fotiadou, Anna Di Laura, Anna C. Hirschmann, Robert Lee, Alister J. Hart
Summary: Running 500 miles over 4 months plus a marathon for the first time had no adverse effects on the lumbar spine, even when early degenerative changes were present. Additionally, there was evidence of regression of sacroiliac joint abnormalities.
SKELETAL RADIOLOGY
(2022)
Article
Orthopedics
Martina Tognini, Harry Hothi, Stewart Tucker, Edel Broomfield, Masood Shafafy, Panos Gikas, Anna Di Laura, Johann Henckel, Alister Hart
Summary: This study aimed to investigate the normal ranges of blood titanium levels in patients implanted with large and sliding titanium constructs. The results showed that compared to well-functioning, conventionally sized titanium hips, large and sliding orthopaedic implants had higher blood titanium levels, but the increased levels did not induce adverse metal reactions.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Harry Hothi, Johann Henckel, Sean Bergiers, Anna Di Laura, Klaus Schlueter-Brust, Alister Hart
Summary: This study aims to investigate the presence of voids in commercially available custom acetabular cups. The research found that some cups indeed have structural voids, which may increase the risk of crack initiation in the cups.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Martina Tognini, Harry Hothi, Sean Bergiers, Edel Broomfield, Stewart Tucker, Johann Henckel, Alister Hart
Summary: Retrospective analysis of explanted magnetically controlled growing rods (MCGRs) aimed to understand their fracture mechanisms and related risk factors. Findings showed that all fractured rods were single-rod constructs and greater rod contouring angles and distances between anchoring points were significant factors contributing to the fractures. Therefore, implanting double rod constructs in patients with mature spines is preferable to avoid this complication.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2023)
Article
Biotechnology & Applied Microbiology
Sean Bergiers, Johann Henckel, Harry Hothi, Anna Di Laura, Chris Goddard, David Raymont, Furqan Ullah, Ross Cotton, Rebecca Bryan, Alister Hart
Summary: This study aimed to identify the most common locations of wear in vivo by using CT imaging, retrieval analysis, and statistical shape modelling (SSM). The results showed that wear volume, positioning, time, gender, and size had an impact on the location of wear. Understanding the function of hip implants can inform future design and improve the safe zone for implant positioning.
BIOENGINEERING-BASEL
(2023)
Article
Orthopedics
Martin A. Belzunce, Johann Henckel, Anna Di Laura, Laura M. Horga, Alister James Hart
Summary: Physical activity and a healthy lifestyle are important for delaying sarcopenia. This study aimed to quantify the benefits of cycling on muscle health in middle-aged men. The results showed that cyclists had lower levels of intramuscular fat infiltration and larger muscle mass compared to physically inactive individuals.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Sara De Angelis, Johann Henckel, Sean Bergiers, Harry Hothi, Anna Di Laura, Alister Hart
Summary: The assessment of three-dimensional bony defects is important for surgical planning of hip reconstruction. Previous methods using mirroring of the contralateral side may not be useful when diseased or replaced. Statistical Shape Models (SSMs) can aid reconstruction by deriving landmarks for patients with large acetabular defects. Our study found that SSMs can effectively reconstruct bony landmarks in patients with significant lysis, regardless of defect severity. This can assist in surgical planning and implant design for hip reconstruction.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Engineering, Biomedical
Maria Moralidou, Anna Di Laura, Johann Henckel, Alister J. Hart
Summary: Three-Dimensional Computed Tomography planning can predict prosthetic femoral size in un-cemented primary Total Hip Arthroplasty. However, the relationship between Prosthetic Femoral Version and Native Femoral Version is not well understood. This study aimed to assess this relationship using 3D-CT analysis.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Critical Care Medicine
Matthew J. Wood, Talal Al-Jabri, Ahmed Zaghloul, Brent Lanting, Peter V. Giannoudis, Alister James Hart
Summary: Periprosthetic acetabular fractures are rare but potentially serious complications of total hip arthroplasty. There is a lack of literature on these fractures compared to periprosthetic femoral fractures after total hip arthroplasty. This article provides an up-to-date review of the epidemiology, risk factors, diagnostic challenges, classifications, and management strategies for periprosthetic acetabular fractures after total hip arthroplasty.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Angelika Ramesh, Anna Di Laura, Johann Henckel, Alister Hart
Summary: CT is commonly used for pre-operative planning and assessment of THA, but there is a need for a harmonised low-dose protocol due to the variability in existing protocols. Most protocols are incomplete and only a small percentage are optimised for both field of view and image acquisition parameters. The variability emphasizes the need for a more consistent and optimal protocol for THA planning.
EFORT OPEN REVIEWS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harry Hothi, Arianna Cerquiglini, Lukas Buel, Johann Henckel, Lukas B. Moser, Michael T. Hirschmann, Alister Hart
Summary: This study aimed to investigate the relationship between bone tracer uptake distribution patterns in SPECT/CT and retrieval findings. The results showed that in patients with asymmetric distribution, those with more extended BTU in the medial compartment had significantly thinner insertions in the medial compartment, and vice versa in the lateral side. This study supports the hypothesis that SPECT/CT can identify bone activity due to implant position and loading.
