Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S. Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J. Sandborn
Summary: This study evaluated the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-TNF agents. The results showed that etrolizumab significantly improved remission rates at week 14 compared to placebo, but there was no significant difference between the two groups in remission rates at week 66.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Maryam Khazdouz, Naser Ebrahimi Daryani, Makan Cheraghpour, Foroogh Alborzi, Motahareh Hasani, Shaghayegh Baradaran Ghavami, Farzad Shidfar
Summary: The purpose of this study was to investigate the therapeutic effects of selenium supplementation in ulcerative colitis patients with mild-to-moderate disease activity. The study found that taking selenomethionine capsules significantly reduced disease activity and improved quality of life.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Marcelina Radziszewska, Joanna Smarkusz-Zarzecka, Lucyna Ostrowska, Damian Pogodzinski
Summary: This review analyzed scientific research to determine the impact of different nutritional plans and dietary supplements on the course of ulcerative colitis (UC). The study found that certain components in food can greatly influence UC, with the Mediterranean diet showing promising results in treatment. It also discussed the potential effects of the UC Exclusion Diet (UCED) and unconventional diets, as well as the uncertain therapeutic effects of omega-3 fatty acids and probiotic supplementation.
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Shuji Ikegami, Masanao Nakamura, Takashi Honda, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa, Kenta Yamamoto, Satoshi Furune, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Masatoshi Ishigami, Fumie Kinoshita, Yoshihiro Kadota, Takumi Tochio, Yoshiharu Shimomura, Yoshiki Hirooka, Hiroki Kawashima
Summary: This pilot trial investigated the efficacy of administering 1-kestose to patients with active ulcerative colitis. The results showed that oral 1-kestose improved clinical symptoms and modulated the gut microbiome.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hassan Maleki, Maryam Doostan, Mohammad Hosein Farzaei, Parisa Seifi, Shahram Miraghaee, Mahtab Doostan
Summary: This study aimed to formulate a colon-specific delivery system for A. wilhelmsii extract using chitosan nanoparticles and Eudragit S100. The prepared nanoparticles showed spherical shape, suitable size, and high encapsulation efficiency. They exhibited a pH-sensitive release pattern and effectively mitigated UC-related inflammation and colonic lesions.
Article
Food Science & Technology
Muhammad Abdullah, Naeem Khalid, Javed Ahmed, Ali Nawaz, Jafar Salim, Anwaar Ahmed
Summary: The study demonstrated that supplementing wheat flour with germinated barley flour significantly increased the nutritional quality of chapatti, with notable improvements in protein, minerals, fat, calories, and beta-glucans. The study also found that a 20% substitution level of germinated barley flour in wheat flour resulted in improved rheological properties and good sensory acceptability of the chapatti.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biochemistry & Molecular Biology
Kevin Baker, Charlotte O'Donnell, Maura Bendix, Samuel Keogh, James Byrne, Michael O'Riordain, Peter Neary, Aileen Houston, Elizabeth Brint
Summary: IL-36 cytokines play a significant role in the pathogenesis of colon cancer by activating pro-tumorigenic phenotypes and inducing pro-inflammatory response. Targeting IL-36R signaling may be a useful therapy for colorectal cancer patients with IL-36R(+) tumor cells.
Article
Microbiology
Daotong Li, Yu Feng, Meiling Tian, Junfu Ji, Xiaosong Hu, Fang Chen
Summary: Our study demonstrates that the gut microbiota-inosine-A(2A)R/PPAR gamma axis is crucial in maintaining intestinal homeostasis and may offer a novel approach for preventing colitis through manipulation of gut microbial purine metabolite. Additionally, dietary supplementation of barley leaf improves intestinal mucosal barrier functions and induces metabolic reprogramming in colonic tissues by enhancing the glycolysis process. Furthermore, the enrichment of microbiota-derived purine metabolite inosine from BL supplementation activates PPAR gamma signaling in human colon epithelial cells.
Article
Nutrition & Dietetics
Bridgette Wilson, Oezge Eyice, Ioannis Koumoutsos, Miranda C. Lomer, Peter M. Irving, James O. Lindsay, Kevin Whelan
Summary: Prebiotics may not reduce clinical scores or inflammation in patients with active ulcerative colitis, but can normalize stools. The increase in proportions of Bifidobacterium and Christensenellaceae only occurred in patients with less active diseases, suggesting that the prebiotic effect may depend on disease activity.
Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Health Care Sciences & Services
Laura A. Lucaciu, Maria Ilies, Stefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Summary: Interleukin (IL)-23 and fecal calprotectin levels were significantly elevated in severe inflammatory bowel disease (IBD), while IL-17 and C-reactive protein were associated with disease severity. IL-23 may serve as a promising novel biomarker for severe Crohn's disease, guiding clinical decision-making on biologic therapy. Identifying the main IL pathway involved in IBD severity could provide valuable insights for personalized treatment approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Martinez-Noguera, Cristian Marin-Pagan, Jorge Carlos-Vivas, Pedro E. Alcaraz
Summary: The study showed that chronic ingestion of 2S-hesperidin can increase endogenous antioxidant capacity, decrease oxidative stress, and reduce inflammation in amateur cyclists, providing positive effects on their internal status.
Article
Gastroenterology & Hepatology
Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoichiro Iboshi, Takatoshi Chinen, Toshiaki Ochiai, Hirotada Akiho, Kazuhiko Nakamura, Takuji Gotoda, Yoshihiro Ogawa
Summary: This study showed that mucosally expressed IL-1 beta levels can predict the response to glucocorticoids in patients with ulcerative colitis, providing a potential biomarker to differentiate between glucocorticoid-resistant and glucocorticoid-sensitive ulcerative colitis.
Article
Gastroenterology & Hepatology
Zhao-Xiu Liu, Wei-Jie Chen, Yang Wang, Bing-Qian Chen, Yi-Cun Liu, Tiao-Chun Cheng, Lei-Lei Luo, Lin Chen, Lin-Ling Ju, Yuan Liu, Ming Li, Nan Feng, Jian-Guo Shao, Zhao-Lian Bian
Summary: IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis. IL-34 may serve as a potential therapeutic target in ulcerative colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Neurosciences
Samaneh Hajjarzadeh, Reza Mahdavi, Davood Shalilahmadi, Zeinab Nikniaz
NUTRITIONAL NEUROSCIENCE
(2020)
Article
Nutrition & Dietetics
Azadeh Aminianfar, Farhad Vahid, Mehdi Shayanfar, Sayed Hossein Davoodi, Minoo Mohammad-Shirazi, Nitin Shivappa, Giuve Sharifi, James R. Hebert, Pamela J. Surkan, Zeinab Faghfoori, Ahmad Esmaillzadeh
CLINICAL NUTRITION
(2020)
Article
Oncology
Farhad Vahid, Zeinab Faghfoori, Sayed Hossein Davoodi
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2020)
Article
Nursing
Atoosa Bagherzadeh Chaharjoui, Reza Mahdavi, Zeinab Nikniaz
Summary: This study aimed to identify barriers to American Heart Association dietary recommendations in hypercholesterolemic patients, and found that factors such as psychological factors, false beliefs and food habits affect dietary adherence. Considering these barriers, incorporating patient's culture, traditions, and dietary preferences can be beneficial in improving dietary adherence among hypercholesterolemic patients.
CLINICAL NURSING RESEARCH
(2021)
Article
Genetics & Heredity
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi, Leila Nikniaz, Zeinab Nikniaz
LIFESTYLE GENOMICS
(2020)
Review
Endocrinology & Metabolism
Parvin Dehghan, Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz, Mohammad Asghari-Jafarabadi
Article
Nutrition & Dietetics
Masoud Nasiri, Saja Ahmadizad, Mehdi Hedayati, Tayebe Zarekar, Mehdi Seydyousefi, Zeinab Faghfoori
Summary: Endurance training led to a significant increase in MDA levels and a decrease in total antioxidant capacity, while t-resveratrol supplementation prevented lipid peroxidation induced by exercise. No significant effect was observed on other variables except MDA and TAC in response to training and resveratrol supplementation.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2021)
Article
Nutrition & Dietetics
Zeinab Nikniaz, Reza Mahdavi, Leila Nikniaz, Zahra Akbari Namvar, Masoud Shirmohammadi, Mojgan Akhavan Sabbagh
Article
Gastroenterology & Hepatology
Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Saeideh Ghaffarifar, Zahra Saeedi, Zahra Akbari Namvar, Masood Shirmohammadi
BMC GASTROENTEROLOGY
(2020)
Article
Oncology
Zeinab Faghfoori, Mohammad Hasan Faghfoori, Amir Saber, Azimeh Izadi, Ahmad Yari Khosroushahi
Summary: The study showed that different species of bifidobacteria exhibit anticancer activity on colorectal cancer cells by regulating the expression of anti-apoptotic and pro-apoptotic genes, potentially contributing to the prevention and treatment of colorectal cancer. Further research is needed to fully understand the mechanisms behind apoptosis induction by bifidobacteria species.
CANCER CELL INTERNATIONAL
(2021)
Review
Pediatrics
Elnaz Faramarzi, Reza Mahdavi, Zeinab Nikniaz, Mandana Rafeey, Fatemeh Farshi Radvar
Summary: This systematic review evaluated the application of curcumin in experimental models of cystic fibrosis (CF) and found that the available evidence suggests the potential usefulness of curcumin in CF through various mechanisms. However, more studies are needed in this field to generalize the results to human studies.
IRANIAN JOURNAL OF PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Mansour Sayyah, Mehdi Seydyousefi, Abdorreza Eghbal Moghanlou, Gerlinde A. S. Metz, Nabi Shamsaei, Mohammad Hasan Faghfoori, Zeinab Faghfoori
Summary: This study examined the effect of aerobic exercise on post ischemia/reperfusion injury on concentration and expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) after inducing neuronal loss in the hippocampus of male rats. The results showed that aerobic exercise reduced brain cell death and improved motor skill performance, potentially promoting neuroprotective mechanisms and neuronal repair and survival.
METABOLIC BRAIN DISEASE
(2022)
Article
Health Care Sciences & Services
Zeinab Nikniaz, Zahra Akbari Namvar, Masood Shirmohammadi, Elham Maserat
Summary: This study developed a Persian-language application for celiac disease patients and assessed the effectiveness of a three-month educational intervention delivered via smartphone application. The results showed that using a smartphone application for education had a significant positive effect on indigestion symptoms compared with routine clinic education.
INTERNATIONAL JOURNAL OF TELEMEDICINE AND APPLICATIONS
(2022)
Review
Food Science & Technology
Sevda Zoghi, Amin Abbasi, Fatemah Sadeghpour Heravi, Mohammad Hossein Somi, Zeinab Nikniaz, Seyed Yaghoub Moaddab, Hamed Ebrahimzadeh Leylabadlo
Summary: This article discusses the association between the development of celiac disease and gut microbiota, the effects of infectious agents, especially the recent Covid-19 infection in celiac disease patients, and the efficacy of potential therapeutic approaches. Scientific literature suggests that microbiome-based therapy can improve the symptoms and quality of life of celiac disease patients, but the full potential of microbiota-based techniques requires further research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Masood Faghih Dinevari, Farzaneh Jafarzadeh, Amirreza Jabbaripour Sarmadian, Samaneh Abbasian, Zeinab Nikniaz, Ali Riazi
Summary: This study aimed to investigate the therapeutic effects of melatonin on IBS patients with and without sleep disorders. The results showed that melatonin has positive effects on improving IBS score, GI symptoms, quality of life, and sleep parameters.
BMC GASTROENTEROLOGY
(2023)
