Article
Respiratory System
Zhongshang Dai, Xiangming Liu, Huihui Zeng, Yan Chen
Summary: In COPD patients, HOTAIR expression is up-regulated, promoting HPVEC apoptosis through DNMT1-mediated hypermethylation of the Bcl-2 promoter, and silencing HOTAIR can alleviate cell apoptosis and emphysema. In vitro experiments showed that HOTAIR can exacerbate apoptosis in CSE-exposed HPVEC.
RESPIRATORY RESEARCH
(2022)
Review
Critical Care Medicine
Marilyn K. Glassberg, Isabelle Csete, Emmanuelle Simonet, Sharon J. Elliot
Summary: COPD is a chronic inflammatory and destructive disease with no cure. Mesenchymal stem cells (MSCs) have shown potential as a therapeutic option, but there is currently a lack of evidence supporting their ability to restore lung function in patients with COPD.
Article
Cardiac & Cardiovascular Systems
Kana Fujikura, Alessandra Albini, R. Graham Barr, Megha Parikh, Julia Kern, Eric Hoffman, Grant T. Hiura, David A. Bluemke, James Carr, Joao A. C. Lima, Erin D. Michos, Antoinette S. Gomes, Martin R. Prince
Summary: This study found that patients with COPD and severe emphysema had a larger aorta diameter. Compared to COPD related to chronic bronchitis or bronchial wall thickening, the dilation of aorta was more significant in these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Respiratory System
Nicola Murgia, Angela Gambelunghe
Summary: Chronic obstructive pulmonary disease (COPD) is primarily caused by smoking and occupational exposure, with the latter often being underestimated. Early diagnosis, identification of occupational causes, and collaborative treatment are crucial for preventing further decline in lung function and reducing the burden of COPD.
Article
Immunology
Di Wang, Bingnan Chen, Shuang Bai, Li Zhao
Summary: This study identified three immune cells significantly associated with emphysema phenotype clinical features, including increased proportion of neutrophils and decreased proportions of M2 macrophages and resting mast cells. Through WGCNA and clinical tissue validation, immune-related genes closely related to clinical features were further screened.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Khushboo Goel, Nicholas Egersdorf, Amar Gill, Danting Cao, Scott D. Collum, Soma S. Jyothula, Howard J. Huang, Maor Sauler, Patty J. Lee, Susan Majka, Harry Karmouty-Quintana, Irina Petrache
Summary: This study investigated the remodeling of pulmonary blood vessels in COPD-PH patients and found that remodeling of small and microvascular pulmonary blood vessels is associated with the development of COPD and COPD-PH. Decreased expression of miR126 and reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in COPD and COPD-PH.
RESPIRATORY RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
D. Pellegrino, S. Casas-Recasens, R. Faner, P. Palange, A. Agusti
Summary: The term GETomics refers to the concept that human health and disease are the result of dynamic gene-environment interactions occurring throughout a person's lifetime. This approach has led to a dramatic shift in our understanding of chronic obstructive pulmonary disease (COPD), as it is not solely caused by smoking and affects both genders and different age groups. By applying a GETomics approach, new perspectives on the relationship between COPD, exercise limitation, and aging can be gained.
RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maor Sauler, John E. McDonough, Taylor S. Adams, Neeharika Kothapalli, Thomas Barnthaler, Rhiannon B. Werder, Jonas C. Schupp, Jessica Nouws, Matthew J. Robertson, Cristian Coarfa, Tao Yang, Maurizio Chioccioli, Norihito Omote, Carlos Cosme, Sergio Poli, Ehab A. Ayaub, Sarah G. Chu, Klaus H. Jensen, Jose L. Gomez, Clemente J. Britto, Micha Sam B. Raredon, Laura E. Niklason, Andrew A. Wilson, Pascal N. Timshel, Naftali Kaminski, Ivan O. Rosas
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, but our understanding of cell-specific mechanisms underlying COPD pathobiology remains incomplete. In this study, the authors used single-cell RNA sequencing to analyze human lung tissue and identified transcriptional changes in alveolar niche cells associated with the disease.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Suneeta Godbole, Russell P. Bowler
Summary: COPD is a complex lung disease with systemic manifestations that disrupt the metabolome in extrapulmonary compartments. A scoping review of COPD metabolomics literature revealed dysregulation in various metabolic pathways, influenced by age and sex. There is a lack of research on the association between the metabolome and COPD progression, warranting further investigation.
Article
Respiratory System
Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O'Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler
Summary: sRAGE is associated with emphysema and airflow obstruction, with lower sRAGE levels linked to a COPD diagnosis, reduced FEV1, and increased emphysema severity. Genetic variability may influence sRAGE measurements in non-white populations.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Carrie L. Pistenmaa, P. Nardelli, S. Y. Ash, C. E. Come, A. A. Diaz, F. N. Rahaghi, R. G. Barr, K. A. Young, G. L. Kinney, J. P. Simmons, R. C. Wade, J. M. Wells, J. E. Hokanson, G. R. Washko, R. San Jose Estepar
Summary: This study reveals a significant association between pulmonary arterial pruning and rapid progression of emphysema percentage and decline in FEV1 to FVC ratio over 5 years in ever smokers. These findings suggest that pulmonary vascular differences may play a crucial role in the progression of the disease.
Review
Physiology
Farrah Kheradmand, Yun Zhang, David B. Corry
Summary: The pathophysiology of chronic obstructive pulmonary disease (COPD) has long focused on innate immune cells, but recent data suggests that adaptive immune cells also contribute to lung destruction. The presence of activated and organized adaptive immune cells in emphysematous lungs indicates their role in COPD. Experimental models have shown that Th1 and Th17 subsets activate innate immune cells, confirming their involvement in emphysema pathogenesis.
PHYSIOLOGICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Bianca Beghe, Stefania Cerri, Leonardo M. Fabbri, Alessandro Marchioni
Summary: Aging and smoking are associated with the development of three main pulmonary diseases: COPD, ILAs, and IPF. These diseases manifest mainly after the age of 60, each with different natural histories and prevalence. While COPD and ILAs may have gradual progression, the natural history of IPF remains unclear with a worse prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Gizem Guenes Guensel, Thomas M. Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertuez, Niklas J. Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C. Pestoni, Stephanie L. Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P. Van Eeckhoutte, Oezgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-Lopez, Carlos M. Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E. Verleden, Bart Vanaudenaerde, Melanie Koenigshoff, Gunnar Dittmar, Ken R. Bracke, Joachim L. Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B. Schiller, Marcus Conrad, Robert Schneider, Ali Oender Yildirim
Summary: This study demonstrates the role of PRMT7 in regulating the recruitment and pro-inflammatory phenotype of macrophages in chronic obstructive pulmonary disease (COPD). Reduced expression of PRMT7 is associated with decreased recruitment of monocytes to the site of injury and less severe symptoms in mouse models.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Michael N. Armitage, Daniella A. Spittle, Alice M. Turner
Summary: A systematic review and meta-analysis found that approximately 41% of patients with stable COPD have potentially pathogenic microorganisms (PPMs) in their sputum. The most common PPMs reported were H. influenzae, M catarrhalis, S. pneumoniae, S. aureus, and P. aeruginosa. There was a weak correlation between declining lung function and prevalence of PPMs.