Review
Endocrinology & Metabolism
Cunqing Yang, Xuefei Zhao, Xuedong An, Yuehong Zhang, Wenjie Sun, Yuqing Zhang, Yingying Duan, Xiaomin Kang, Yuting Sun, Linlin Jiang, Fengmei Lian
Summary: Diabetic peripheral neuropathy is a chronic metabolic disease that seriously affects patients' quality of life and can lead to amputation and neuropathic pain. Current treatment options only address symptoms and do not reverse nerve damage. Understanding the underlying mechanisms is crucial for prevention and the development of new therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ziyin Liu, Qi Wang, Wei Sun, Qipeng Song
Summary: The purpose of this study was to investigate the correlations of lower extremity muscle strength, proprioception, and tactile sensation to postural stability among older adults with and without sensory deficits, and to explore sensory reweighting among the two populations. The results showed that older adults with sensory deficits had lower BBS scores and higher proprioception thresholds, while lower extremity muscle strength and proprioception were correlated with BBS among older adults without sensory deficits. Older adults with sensory deficits have poorer proprioception and postural stability, and somatosensory reweighting occurs from proprioception to tactile sensation among them.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dermatology
Mar Sempere-Bigorra, Lorenzo Brognara, Ivan Julian-Rochina, Antonio Mazzotti, Omar Cauli
Summary: This study explores the potential usefulness of gait analysis parameters using a single sensor unit to detect peripheral neuropathy in diabetic patients with diabetic foot. The study finds significant correlations between impaired deep sensory pathways and gait impairments in diabetic patients, as well as significant correlations between all gait parameters and the superficial sensory pathway. The findings suggest that inertial sensors could be a useful tool for diagnosing gait alterations and evaluating treatment effects in diabetic patients to improve gait and reduce the risk of falls.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Takeshi Yamamotoya, Shun Hasei, Yasuyuki Akasaka, Yukino Ohata, Yusuke Nakatsu, Machi Kanna, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Akifumi Kushiyama, Hidemi Misawa, Tomoichiro Asano
Summary: Loss of Trk-fused gene (TFG) in motor neurons leads to neuromuscular junction (NMJ) degeneration and muscle atrophy, while lack of TFG in muscles may have additional effects. These findings are important for understanding the mechanisms associated with neurodegenerative diseases.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Zsuzsanna Putz, Dora Tordai, Noemi Hajdu, Orsolya Erzsebet Vagi, Miklos Kempler, Magdolna Bekeffy, Anna Erzsebet Korei, Ildiko Istenes, Viktor Horvath, Anca Pantea Stoian, Manfredi Rizzo, Nikolaos Papanas, Peter Kempler
Summary: This review summarizes the role of vitamin D in diabetic neuropathy and the latest data on its treatment. Studies suggest that vitamin D deficiency is associated with peripheral neuropathy, diabetic foot ulcers, and cardiac autonomic neuropathy in diabetes. Vitamin D supplementation may be an effective adjunctive therapy for neuropathic pain and can potentially slow down the progression of neural damage.
CLINICAL THERAPEUTICS
(2022)
Review
Clinical Neurology
Pei Shang, Mingqin Zhu, Ying Wang, Xiangyu Zheng, Xiujuan Wu, Jie Zhu, Jiachun Feng, Hong-Liang Zhang
Summary: Axonal variants of Guillain-Barre syndrome (GBS) have diverse triggers, but key questions remain unanswered and current therapies have limitations. Autoantibody classification and electrophysiology are crucial for differentiation, with emerging technologies facilitating more accurate diagnosis.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Zekrayat J. H. Medras, Yasser M. Mostafa, Amal A. M. Ahmed, Norhan M. El-Sayed
Summary: This study found that arctigenin (ARC) can improve diabetic neuropathy (DN) by combating apoptosis and oxidative stress and improving autophagy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Jamie Burgess, Bernhard Frank, Andrew Marshall, Rashaad S. Khalil, Georgios Ponirakis, Ioannis N. Petropoulos, Daniel J. Cuthbertson, Rayaz A. Malik, Uazman Alam
Summary: Diabetic peripheral neuropathy is a common complication of diabetes that significantly impacts quality of life and healthcare burden. Current screening methods for early detection of DPN have limitations, highlighting the need for further research and clinical practices to improve accuracy and early detection.
Article
Pharmacology & Pharmacy
Chun-Chang Yeh, Chong-Chi Chiu, Jhi-Joung Wang, An-Kuo Chou, Yu-Wen Chen, Guan-Cheng Zhu, Ching-Hsia Hung
Summary: This study investigated the sensory and motor block effects of antiparkinsonian drugs (pramipexole and selegiline) and the combination of pramipexole and lidocaine on spinal blockade. Pramipexole displayed more potent and longer-lasting block effects compared to selegiline, but both were less potent than lidocaine. When coadministered with lidocaine, pramipexole improved the efficacy and duration of the spinal block. Overall, pramipexole showed promise in enhancing the effectiveness of lidocaine as a spinal anesthetic.
PHARMACOLOGICAL REPORTS
(2022)
Article
Endocrinology & Metabolism
Ariel Odriozola, Lucia Ortega, Lidia Martinez, Samantha Odriozola, Ainhoa Torrens, David Corroleu, Silvia Martinez, Meritxell Ponce, Yolanda Meije, Mercedes Presas, Alejandra Duarte, M. Belen Odriozola, Rayaz A. Malik
Summary: In this study, four diabetic patients hospitalized with severe COVID-19 infection were found to have neuropathic symptoms and sensory dysfunction based on QST results, characterized by numbness in the feet. The results suggest that hypoxemia caused by COVID-19 infection may lead to neuropathic symptoms and sensory dysfunction.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Annamaria Landolfi, Claudia Vinciguerra, Francesco Diana, Filomena Murano, Maria Claudia Russillo, Paolo Barone, Bianca Serio, Giuseppe Piscosquito
Summary: We present a case of intrathecal methotrexate toxicity in a patient with acute lymphoblastic leukemia and summarize existing literature on this topic. The patient developed flaccid paraparesis, which improved with treatment. The literature review confirms the selective involvement of lumbosacral ventral roots in intrathecal methotrexate toxicity, possibly due to localized folate deficiency or immune-mediated mechanisms.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Zhong Luo, Linhai Zhang, Juan Yang, Haiqing Zhang, Tao Liang
Summary: This case report presents a CMT patient with SOD1 gene mutation, providing new insights for clinical diagnosis of the disease. CMT is a neurodegenerative disease that can be slowed by physical therapy and rehabilitation, but cannot be cured.
Article
Biochemistry & Molecular Biology
Mohamad-Reza Aghanoori, Prasoon Agarwal, Evan Gauvin, Raghu S. Nagalingam, Raiza Bonomo, Vinith Yathindranath, Darrell R. Smith, Yan Hai, Samantha Lee, Corinne G. Jolivalt, Nigel A. Calcutt, Meaghan J. Jones, Michael P. Czubryt, Donald W. Miller, Vernon W. Dolinsky, Virginie Mansuy-Aubert, Paul Fernyhough
Summary: Aberrant insulin-like growth factor 1 (IGF-1) signaling may be associated with the development of neurodegenerative disorders, and the role of endogenous IGF-1 in neuroprotection is not well established. In this study, high expression of IGF-1 was found in non-peptidergic neurons and satellite glial cells of dorsal root ganglia, and bidirectional transport of IGF-1 along sensory nerves was observed. However, IGF-1 gene expression was reduced in diabetic rats and mice, and this suppression could contribute to neuropathy. CEBP beta overexpression promoted neurite outgrowth and mitochondrial respiration, both of which were affected by IGF-1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Dimitrios Tsilingiris, Lukas Schimpfle, Ekaterina von Rauchhaupt, Alba Sulaj, Lukas Seebauer, Hannelore Bartl, Stephan Herzig, Julia Szendroedi, Stefan Kopf, Zoltan Kender
Summary: This study aims to investigate the association between early peripheral sensory dysfunction (EPSD) and factors related to dysmetabolic status in individuals with and without type 2 diabetes (T2DM), as well as the impact of these factors on peripheral neuropathy (PN) development. The results showed that higher insulin resistance was independently associated with EPSD in individuals without T2DM, while metabolic syndrome and skin advanced glycation end-products (AGEs) were independent predictors of EPSD in T2DM. Longitudinal analysis revealed that T2DM, EPSD, higher insulin resistance, and AGEs predicted PN development. Among the three EPSD-associated sensory phenotypes, sensory loss was most strongly associated with PN development.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Anesthesiology
Jonathan Enders, Matthew Taylor Swanson, Janelle Ryals, Douglas E. Wright
Summary: Through experiments on type 1 diabetic mice, it was found that a ketogenic diet can improve changes in metabolic biomarkers, sensory thresholds, and skin nerve fiber innervation, indicating that a ketogenic diet may be a potential therapeutic intervention for painful diabetic neuropathy and epidermal nerve fiber loss.
Article
Endocrinology & Metabolism
Marc Leal-Julia, Jorge J. Vilches, Andrea Onieva, Sergi Verdes, Angela Sanchez, Miguel Chillon, Xavier Navarro, Assumpcio Bosch
Summary: This study characterized the proteome of neural tissues in a type 2 diabetes mouse model and identified differential protein expression profiles related to reduced glycolytic and TCA cycle metabolism, increased lipid catabolism, dysregulation of muscle-like proteins, altered cytoskeleton-related proteins, activation of inflammatory responses, and changes in glutathione metabolism and oxidative stress. These findings suggest that energy deficiency may play a key role in the neurodegeneration observed in diabetic neuropathy.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Miguel A. Rubio, Mireia Herrando-Grabulosa, Roser Velasco, Israel Blasco, Monica Povedano, Xavier Navarro
Summary: This study found increased levels of TDP-43 in the skin of ALS patients, which may serve as a potential biomarker for early diagnosis of ALS.
Article
Neurosciences
Georgina Palomes-Borrajo, Xavier Navarro, Clara Penas
Summary: This study demonstrates that inhibiting BET proteins in macrophages can enhance axonal outgrowth and promote peripheral nerve regeneration. However, specific targeting of BET proteins to macrophages is needed for efficient functional recovery after nerve injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Engineering, Biomedical
Giacomo Valle, Giovanna Aiello, Federico Ciotti, Paul Cvancara, Tamara Martinovic, Tamara Kravic, Xavier Navarro, Thomas Stieglitz, Marko Bumbasirevic, Stanisa Raspopovic
Summary: Bioelectronic medicine shows promise in treating disabilities through implantable neural interfaces. However, the long-term stability of implants and nerve reactions remains unclear. Research has found that neurostimulation can evoke different sensations over time, emphasizing the importance of improving nerve-electrode interface design.
Article
Neurosciences
J. Sanchez-Ventura, C. Canal, J. Hidalgo, C. Penas, X. Navarro, A. Torres-Espin, K. Fouad, E. Udina
Summary: This study aims to elucidate the role of spinal PNNs on motor function and plasticity. Lack of Crtl1 can lead to disorganized PNNs, altering excitatory synapses and affecting the physiological properties of motoneurons, resulting in motor impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Estefania Contreras, Sara Traserra, Sara Bolivar, Joaquim Fores, Eduard Jose-Cunilleras, Ignacio Delgado-Martinez, Felix Garcia, Esther Udina, Xavier Navarro
Summary: This study used sheep as a model to investigate the repair of long-gap peripheral nerve injuries through autograft transplantation. Functional evaluation, electromyographic and ultrasound tests were performed. The results suggest that sheep nerve repair is a useful model for studying such injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Miguel A. Rubio, Mireia Herrando-Grabulosa, Xavier Navarro
Summary: This article provides a comprehensive review of the involvement of sensory and autonomic systems in amyotrophic lateral sclerosis (ALS) from various perspectives, including clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Estefania Contreras, Sara Traserra, Sara Bolivar, Joaquim Fores, Eduard Jose-Cunilleras, Felix Garcia, Ignacio Delgado-Martinez, Sandra Holmgren, Raimund Strehl, Esther Udina, Xavier Navarro
Summary: Decellularized nerve allografts are a viable option for repairing severe peripheral nerve injuries, as shown by successful regeneration in sheep nerves.
Article
Multidisciplinary Sciences
Joan Roig-Soriano, Cristina Sanchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdes, Carmela R. Abraham, Assumpcio Bosch, Francesc Ventura, Miguel Chillon
Summary: The gene alpha-Klotho produces two main transcripts, one encoding a transmembrane protein detected in serum as processed Klotho (p-KL), and the other coding for a putatively secreted protein (s-KL). While p-KL showed negative effects on mineral homeostasis and bone microstructure, s-KL demonstrated no apparent negative effects on mineral metabolism and presented unexpected beneficial effects on bone microstructure. These findings suggest that s-KL (but not p-KL) may be a safe therapeutic strategy for exploiting KL anti-aging protective effects.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Ariadna Arbat-Plana, Sara Bolivar, Xavier Navarro, Esther Udina, Francisco J. Alvarez
Summary: Peripheral nerve injuries result in the retraction of Ia synapses from a-motoneurons, impairing functional recovery and correlating with injury severity and muscle reinnervation efficiency. This study analyzed VGluT1-labeled Ia synapses after nerve crush in 10-day-old rats and found a large loss of synapses similar to more severe injuries in adults. The mechanism of synapse loss in young animals may be associated with higher microglia synaptic pruning activity and results in greater losses after milder nerve injuries.
Article
Engineering, Biomedical
Simone Romeni, Elena Losanno, Elisabeth Koert, Luca Pierantoni, Ignacio Delgado-Martinez, Xavier Navarro, Silvestro Micera
Summary: Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. We propose an optimization workflow that can guide pre-surgical planning and determine maximally selective multisite stimulation protocols for intraneural implants. Our method utilizes hybrid models and machine learning to optimize implant geometry, insertion, and stimulation protocols, leading to high selectivity and potential for motor function restoration.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Eugenio Redolfi-Riva, Miriam Perez-Izquierdo, Ciro Zinno, Estefania Contreras, Bruno Rodriguez-Meana, Federica Iberite, Leonardo Ricotti, Silvestro Micera, Xavier Navarro
Summary: This study introduces a novel design of nerve conduit composed of a chitosan porous matrix and a 3D-printed poly-& epsilon;-caprolactone mesh. The conduits show high controllability and can support nerve regeneration, enabling the repair of long nerve defects. Animal experiments demonstrate muscle functional recovery and abundant cellularization and axon regeneration within the conduits, suggesting their potential to overcome the limitations of autograft for repairing long nerve gaps.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Sergi Verdes, Mireia Herrando-Grabulosa, Ruben Guerrero-Yague, Joan Roig-Soriano, Nuria Gaja-Capdevila, Marc Leal-Julia, Andrea Onieva, Laura Rodriguez-Estevez, Javier Del Rey, Neus Hernandez, Miguel Chillon, Xavier Navarro, Assumpcio Bosch
Meeting Abstract
Biotechnology & Applied Microbiology
S. Verdes, M. Herrando-Grabulosa, R. Guerrero-Yague, J. Roig-Soriano, N. Gaja-Capdevila, M. Leal-Julia, A. Onieva, M. Chillon, X. Navarro, A. Bosch
HUMAN GENE THERAPY
(2022)