Article
Multidisciplinary Sciences
Congping Chen, Zhentao She, Peng Tang, Zhongya Qin, Jufang He, Jianan Y. Qu
Summary: The study presented an approach for imaging neurovascular dynamics in live mouse cortices using multi-contrast mesoscopic and two-photon microscopic imaging, revealing the spatiotemporal correlation between neuronal and vascular responses. The research uncovered significant differences in NVC at regional and microvascular levels, as well as the impact of different brain states on NVC, particularly showing that anesthesia and sedation disrupt NVC.
Article
Cardiac & Cardiovascular Systems
Michael Boily, Lin Li, Diane Vallerand, Helene Girouard
Summary: The study revealed that Angiotensin II impairs neurovascular coupling by enhancing astrocytic calcium responses, promoting vasoconstriction over vasodilation and altering cerebral blood flow increases in response to neuronal activity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Neuroimaging
Smrithi Sunil, John Jiang, Shashwat Shah, Sreekanth Kura, Kivilcim Kilic, Sefik Evren Erdener, Cenk Ayata, Anna Devor, David A. Boas
Summary: Functional neuroimaging has great potential for monitoring stroke recovery and guiding rehabilitation, but it is unclear if the altered hemodynamic responses after stroke reflect underlying brain physiology or simply vascular injury. To address this, we simultaneously captured neural activity and hemodynamics during longitudinal stroke recovery and found that functional neuroimaging accurately represents chronic stroke. Sub-acute changes in neurovascular coupling were predictive of long-term behavioral outcomes. These results support the use of hemodynamic measures post-stroke for predicting functional and behavioral outcomes.
NEUROIMAGE-CLINICAL
(2023)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Shruti Joshi, Lucy E. Kershaw, Andy H. Baker, Gerry P. McCann, Dana K. Dawson, Marc R. Dweck, Scott I. Semple, David E. Newby
Summary: Patients with takotsubo syndrome exhibit significant myocardial manganese uptake abnormality, most pronounced in the acute phase but persisting for at least 3 months despite apparent restoration of normal left ventricular ejection fraction.
Review
Biochemistry & Molecular Biology
Shashank Shekhar, Yedan Liu, Shaoxun Wang, Huawei Zhang, Xing Fang, Jin Zhang, Letao Fan, Baoying Zheng, Richard J. Roman, Zhen Wang, Fan Fan, George W. Booz
Summary: Ischemic stroke is a disabling disease with increasing global burden and no effective treatments available to limit or reverse brain ischemic injury. Recent findings suggest that TRPC6 channels may play a role in protecting neuronal tissue, but their effects on non-neuronal cells and the blood-brain barrier require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Maria Sancho, Mark T. Nelson
Summary: The study provides profound insights into how the capillary endothelial TRPA1 channel contributes to blood flow control and functional hyperemia in the brain.
Article
Neurosciences
Joscelin E. G. Smith, Jesse L. Ashton, Liam P. Argent, Juliette E. Cheyne, Johanna M. Montgomery
Summary: The intrinsic cardiac nervous system (ICNS) consists of interconnected clusters of neurons known as ganglionated plexi (GP) which play a crucial role in controlling heart rate and rhythm. Plasticity in GP neural networks is believed to be responsible for cardiac arrhythmias such as atrial fibrillation (AF). In this study, a calcium imaging method was developed to visualize plasticity in neuronal activity in intact atrial GP networks in rats with chronic hypertension, and the results showed significant differences in calcium responses between hypertensive rats and normal controls, suggesting a potential link between arrhythmia and plasticity in calcium dynamics in GP neurons.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Qi Zhang, Qihuang Gong, Ying Gu
Summary: The strong confined electromagnetic field in micro/nano photonic structures provides new opportunities for studying the interaction between light and matter, enabling reversible or irreversible energy exchange between photons and emitters at the micro/nano scale by designing optical modes. Recent advances in strong coupling based on micro/nano photonic structures will have significant impact on the research of quantum nanophotonics and on-chip quantum devices.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Behavioral Sciences
Honghao Xu, Kefan Chen, Haitao Zhu, Jinxin Bu, Lu Yang, Fangqing Chen, Haiyan Ma, Xuefeng Qu, Rui Zhang, Hongyi Liu
Summary: The study reveals coupling alterations of regional homogeneity (ReHo) and cerebral blood flow (CBF) in patients with MRI-negative focal epilepsy, providing new insights into the neuropathological mechanisms of this condition.
EPILEPSY & BEHAVIOR
(2023)
Review
Endocrinology & Metabolism
Frank C. T. van der Heide, Thomas T. van Sloten, Nele Willekens, Coen D. A. Stehouwer
Summary: Dysfunction of the neurovascular coupling unit may contribute to dementia, but its role in early-stage pathobiology remains unclear. Limited data are available on the association between neurovascular coupling unit dysfunction and cognitive performance, particularly in population-based studies. Retinal imaging techniques offer a non-invasive, accurate, and relatively inexpensive alternative to cerebral imaging techniques, and show potential for studying the associations between retinal indices and structural brain abnormalities and cognitive performance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jinmei Song, Yanpeng Shi, Meiping Li, Xiaoyu Liu, Xiaodong Wang, Fuhua Yang, Huayu Feng
Summary: By utilizing Mie resonance coupling effects, low-loss silicon particles can be used as receiving or transmitting antennas to localize the electromagnetic field in the terahertz region. This leads to enhanced extraordinary optical transmission (EEOT) when two silicon particles are symmetrically placed on both sides of subwavelength hole arrays. The proposed structure exhibits enhanced factors of 154 and 629 compared to the hole-only structure, and the Mie resonance coupling and induced THz EEOT can be adjusted over a wide frequency range.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Physical
Jinsong Liu, Jixun Chen, Zhengying Wu, Kongjun Zhu, Jing Wang, Ziquan Li, Guoan Tai, Xiaoqin Liu, Songlong Lu
Summary: The synthesis and properties of AgI nanoparticles decorated with ZnO flower-like composites were investigated, showing high photocatalytic efficiency and stability in the degradation of organic pollutants. Ultrasonic vibration can accelerate the separation of carriers, enhancing the photodegradation effect.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Endocrinology & Metabolism
Hyun-Kyoung Lim, Nayeon You, Sungjun Bae, Bok-Man Kang, Young-Min Shon, Seong-Gi Kim, Minah Suh
Summary: This study revealed the differential effects of excitatory and inhibitory neurons on vascular responses in epilepsy states. Preictal vascular activity, gamma-band power, and neuronal activity levels were closely related, with distinct roles played by different types of neurons in different epileptic states.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Fan Yang, Jing Li, Yan Song, Mingrui Zhao, James E. Niemeyer, Peijuan Luo, Dan Li, Weihong Lin, Hongtao Ma, Theodore H. Schwartz
Summary: This study found that seizures in awake animals are more likely to propagate to the contralateral hemisphere, and hemodynamic changes are more intense in awake mice. Therefore, CBV-based imaging techniques are more accurate for seizure mapping in awake behaving animals compared to BOLD-based imaging techniques.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Yoichi Sasaki, Jerome Gautier, Minghao Li, Lydia Karmazin, Thomas W. Ebbesen, Cyriaque Genet
Summary: Chiral molecule-based organic thin films are important for optoelectronics and light technologies, but understanding their chiroptical responses is challenging. This study investigates the circular dichroism of an optically isotropic neat film and finds a negligible contribution of linear dichroism and linear birefringence. The increase in anisotropy factor in the neat film is explained by intermolecular exciton coupling, and time-dependent density functional theory calculations reveal short-ordered structures in the film. These findings provide insight into chiral light-matter interactions and have potential applications.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Clinical Neurology
Matthew T. Bender, Thomas K. Mattingly, Redi Rahmani, Diana Proper, Walter A. Burnett, Jason L. Burgett, Joshua LEsperance, Jeremy T. Cushman, Webster H. Pilcher, Curtis G. Benesch, Adam G. Kelly, Tarun Bhalla
Summary: Mobile stroke units expedite intravenous thrombolysis and endovascular thrombectomy for stroke patients, but do not show significant differences in clinical outcomes compared to traditional EMS services.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Lea Scherschinski, Redi Rahmani, Visish M. Srinivasan, Joshua S. Catapano, S. Paul Oh, Michael T. Lawton
Summary: Brain arteriovenous malformations (AVMs) are high-pressure, low-resistance vascular structures with a risk of spontaneous rupture. Understanding the cellular and molecular pathways can help prevent their development and progression. Treatment options are diverse and often involve a multidisciplinary approach, with an increasing demand for pharmacologic interventions.
WORLD NEUROSURGERY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Mario V. Russo, Abhinav J. Appukutty, Aadit P. Shah, Harsha K. Mohan, Andy G. S. Daniel, Andrew Pack, Richard Xie
Summary: The intensive program aims to supplement student education and promote collaboration in order to address the growing healthcare needs and bridge the gap between the technical expertise needed to tackle pandemic-related challenges.
NATURE BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Joseph B. Humphries, Daniela J. S. Mattos, Jerrel Rutlin, Andy G. S. Daniel, Kathleen Rybczynski, Theresa Notestine, Joshua S. Shimony, Harold Burton, Alexandre Carter, Eric C. Leuthardt
Summary: Upper extremity weakness in chronic stroke can be improved by using brain-computer interfaces (BCIs) therapy, which may reverse the pathological strengthening of dysfunctional network interactions.
BRAIN-COMPUTER INTERFACES
(2022)
Editorial Material
Clinical Neurology
Rohin Singh, Joelle N. Hartke, Joshua S. Catapano, Lea Scherschinski, Redi Rahmani, Visish M. Srinivasan, Ethan A. Winkler, Christopher S. Graffeo, Michael T. Lawton
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Ramon Nogueira, Chris C. C. Rodgers, Randy M. M. Bruno, Stefano Fusi
Summary: Neurons encode non-linear functions of multiple task variables, but the somatosensory cortex of mice reflects a linear integration of whisker contacts. However, there is a structure in the representational geometry where different whisker contacts are represented as disentangled variables in approximately orthogonal subspaces. This geometry allows linear readouts to perform various tasks without compromising the ability to generalize.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Rachel Babij, Camilo Ferrer, Alexander Donatelle, Sam Wacks, Amanda M. Buch, James E. Niemeyer, Hongtao Ma, Zhe Ran S. Duan, Robert N. Fetcho, Alicia Che, Takumi Otsuka, Theodore H. Schwartz, Ben S. Huang, Conor Liston, Natalia V. De Marco Garcia
Summary: This study reveals that dysfunction of GABAergic circuits, which are associated with neurodevelopmental disorders, is influenced by genetic predispositions. Using in vivo imaging in developing mice, the researchers found that the Gabrb3 gene, strongly associated with ASD and AS, plays a crucial role in the inhibitory function of contralaterally projecting pyramidal neurons. The deletion of Gabrb3 leads to a decrease in GABAergic synapses, increased network synchrony, and enhanced functional connectivity in contralateral-pyramidal neuron subtypes.
Article
Clinical Neurology
Redi Rahmani, Irakliy Abramov, Visish M. Srinivasan, Mohamed A. Labib, Lena Mary Houlihan, Joshua S. Catapano, Peter Q. Quinn, Michael T. Lawton, Mark C. Preul
Summary: This study describes a novel approach to the treatment of petroclival and anterior pontine lesions through the mandibular fossa. The approach combines the advantages of endoscopic and open approaches, providing enhanced control and a more anterior angle. Further studies are needed before clinical application.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2023)
Review
Clinical Neurology
Visish M. Srinivasan, Katherine Karahalios, Nathan A. Shlobin, Stefan W. Koester, Candice L. Nguyen, Kavelin Rumalla, Redi Rahmani, Joshua S. Catapano, Mohamed A. Labib, Alim P. Mitha, Robert F. Spetzler, Michael T. Lawton
Summary: This study assessed the characteristics and surgical outcomes of residual intramedullary spinal cord cavernous malformations (SCCMs) and described techniques to avoid leaving lesion remnants during primary resection. Residual SCCMs cause significant symptoms and satisfactory results can be achieved with their removal.
OPERATIVE NEUROSURGERY
(2023)
Article
Neuroimaging
Derrek Schartz, Sajal Medha K. Akkipeddi, Siddharth Chittaranjan, Redi Rahmani, Aditya Gunturi, Nathaniel Ellens, Gurkirat Singh Kohli, Alex Kessler, Thomas Mattingly, Craig Morrell, Tarun Bhalla, Matthew T. Bender
Summary: This study used mass spectrometry to analyze the protein composition of thrombi in 24 patients with acute ischemic stroke. It found that thrombi with hyperdense cerebral artery sign (HCAS) had specific differential protein abundance, while thrombi without HCAS were enriched in certain proteins such as soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein and tyrosine-protein kinase Fyn. In addition, thrombi without HCAS were also enriched in biological processes involving plasma lipoprotein and protein-lipid remodeling/assembling, and lipoprotein metabolic processes, as well as cellular components including mitochondria. These findings suggest that HCAS reflects distinct proteomic composition in AIS thrombus.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Saritha Krishna, Abrar Choudhury, Michael B. B. Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M. M. Molinaro, Humsa S. S. Venkatesh, Andy G. S. Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F. F. Chang, Anne Findlay, Joanna J. J. Phillips, Srikantan Nagarajan, David R. R. Raleigh, David Brang, Michelle Monje, Shawn L. L. Hervey-Jumper
Summary: This study reveals that gliomas can influence neural circuits and cognition through bidirectional interactions with neurons. Gliomas remodel functional neural circuitry and promote tumor progression while impairing cognition. The degree of functional connectivity between glioblastoma and the normal brain negatively affects patient survival and performance in language tasks.
Article
Clinical Neurology
Derrek Schartz, Taylor Furst, Nathaniel Ellens, Gurkirat Singh Kohli, Redi Rahmani, Sajal Medha K. Akkipeddi, Tyler Schmidt, Tarun Bhalla, Thomas Mattingly, Matthew T. Bender
Summary: This study investigated the effect of preoperative embolization (PE) on meningioma surgical resection through a meta-analysis of matched cohort studies. The results showed that PE facilitates lower overall complications, lower major surgical complications, and improved functional independence.
CLINICAL NEURORADIOLOGY
(2023)
Article
Biology
Luke W. Boorman, Samuel S. Harris, Osman Shabir, Llywelyn Lee, Beth Eyre, Clare Howarth, Jason Berwick
Summary: This study developed a multimodal approach to investigate the effects of temperature changes on neurovascular coupling in rats. The results showed that changes in cortical temperature significantly modulate neurovascular coupling, providing insights into the relationship between neurovascular coupling and brain thermodynamics. This has important implications for brain-temperature related therapies, functional biomarkers of elevated brain temperature, and in-vivo methods to study neurovascular coupling.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Visish M. Srinivasan, Katherine Karahalios, Vamsi P. Reddy, Lea Scherschinski, Joseph D. DiDomenico, Redi Rahmani, Joshua S. Catapano, Mohamed A. Labib, Kavelin Rumalla, Christopher S. Graffeo, Michael T. Lawton
Summary: The objective of this paper was to assess the applications of the STIO approach for cerebrovascular neurosurgery. A cohort study and systematic review were conducted, finding that the STIO approach was used in 25 cerebrovascular cases. The conclusion is that the STIO approach is a safe and effective skull base approach.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Bidhan Lamichhane, Patrick H. Luckett, Donna Dierker, Ki Yun Park, Harold Burton, Michael Olufawo, Gabriel Trevino, John J. Lee, Andy G. S. Daniel, Carl D. Hacker, Daniel S. Marcus, Joshua S. Shimony, Eric C. Leuthardt
Summary: This study evaluated the potential predictive value of morphological changes in the brain for overall survival in patients with glioblastoma (GBM) and high-grade glioma (HGG). The findings revealed thinning of gray matter in the contralesional hemisphere and cortical thinning in various lobes. Cortical thickness in the contralesional hemisphere, lobes, and parcels showed predictive value for overall survival, with an accuracy of 83.3% using a machine learning classification algorithm.
NEURO-ONCOLOGY ADVANCES
(2023)