Review
Physiology
Dongqing Pang, Yi Gao, Limin Liao
Summary: This article reviews previous studies and combines the latest findings to discuss brain regions, networks, and changes in brain function related to bladder control in various diseases. The study found that these regions form subnetworks through functional connections to achieve bladder control and identified changes in brain functional connectivity networks related to bladder control.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agronomy
Peter Keil, Beate Gundel, Andre Guendel, Hardy Rolletschek, Ljudmilla Borisjuk
Summary: The non-invasive analysis of seeds is of great interest in seed research and industry. In this study, the combination of near-infrared spectroscopy (NIRS) and time-domain nuclear-magnetic-resonance spectroscopy (TD-NMR) was demonstrated to be a practical approach for individual seed measurements. The method showed high accuracy in estimating nitrogen content, water content, and seed weight of individual oat grains.
Article
Materials Science, Multidisciplinary
Junyi Li, Junhong Duan, Yunjie Liao, Xiaohe Liu, Pengfei Rong, Gen Chen, Hao Wan, Renzhi Ma
Summary: A new Gd1-xNdx(CO3)OH@SiO2 core-shell nanostructure was developed for dual functional imaging in biomedical applications. The nanospheres exhibited strong luminescence in the near-infrared (NIR) region and distinct contrast enhancement in MRI trials. This material showed superior performance as a dual functional imaging platform due to its low concentration of leaching Gd3+ and good biocompatibility.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Weihong Guo, Yingxin Ren, Zhian Chen, Guodong Shen, Yudie Lu, Huimin Zhou, Zhenyuan Li, Zhenhao Li, Xuanyi Lu, Guoxin Li, Zheyu Shen, Yanfeng Hu
Summary: This study develops a T-1-weighted MRI contrast agent that improves the accuracy of diagnosing peritoneal metastasis in gastric cancer, and plays a crucial role in intraoperative navigation and treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yoo Hwan Kim, Seung-Ho Paik, Youngmin Kim, Jaechul Yoon, Yong Suk Cho, Dohern Kym, Jun Hur, Wook Chun, Beop-Min Kim, Byung-Jo Kim
Summary: This study assessed the burn extent and depth in patients with burns using a custom-built 36-channel functional near-infrared spectroscopy system. Hemodynamic tissue signals measured during fNIRS showed significant differences between different burn categories, indicating that functional near-infrared spectroscopy can help with the early judgment of burn extent and depth by reflecting differences in the oxygen saturation levels in the skin.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Corline E. J. Parmentier, Linda S. de Vries, Floris Groenendaal
Summary: Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns. Neuroimaging, including cranial ultrasonography and magnetic resonance imaging (MRI), plays a crucial role in assessing brain injury and predicting outcomes. Advanced imaging techniques such as diffusion tensor imaging and arterial spin labeling provide valuable information about the etiology and prognosis of brain injury.
Article
Neurosciences
Uzair Hakim, Paola Pinti, Adam J. Noah, Xian Zhang, Paul Burgess, Antonia Hamilton, Joy Hirsch, Ilias Tachtsidis
Summary: In this study, a new hemodynamic signal (HPC) was developed to combine HbO(2) and HHb for localization of functional activation. The HPC signal showed comparable accuracy to HHb and was more robust against false positives.
Article
Neurosciences
Amaia Benitez-Andonegui, Michael Luhrs, Laurien Nagels-Coune, Dimo Ivanov, Rainer Goebel, Bettina Sorger
Summary: This study investigates the impact of incorporating varying amounts of individual MRI data on optode layout design in fNIRS-BCI experiments, with more informed approaches showing better performance in signal quality and sensitivity to activation.
Article
Neurosciences
Noam Somech, Tamar Mizrahi, Yael Caspi, Vadim Axelrod
Summary: Naturalistic stimulation is an effective approach in laboratory experiments. The combination of functional near-infrared spectroscopy (fNIRS) and intersubject correlation (ISC) analysis allows for the exploration of cognitive processing and suggests a potential role of the prefrontal cortex in humor appreciation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Kyohei Okubo, Yuichi Kitagawa, Naoki Hosokawa, Masakazu Umezawa, Masao Kamimura, Tomonori Kamiya, Naoko Ohtani, Kohei Soga
Summary: The study demonstrated the use of near-infrared hyperspectral imaging for quantitatively visualizing lipid content in mouse liver, offering a non-invasive method for diagnosing fatty liver. The results show that support vector regression with standard normal variate pretreatment outperforms partial least squares regression in terms of accuracy and performance.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Materials Science, Multidisciplinary
Ying Zhang, Hongfang Du, Panpan He, Chuang Shen, Qi Li, Yefan Duan, Zhouwei Shao, Fei Mu, Feng Huang, Peiyang Li, Pingqi Gao, Peng Yu, Zhimin Luo, Lianhui Wang
Summary: The study successfully synthesized FePS3-PEG nanosheets with excellent photothermal conversion efficiency and magnetic resonance imaging effects, making them promising for T-1 weighted MRI-guided near-infrared photothermal therapy for cancer treatment.
SCIENCE CHINA-MATERIALS
(2021)
Article
Neurosciences
Hui Xie, Xin Li, Gongcheng Xu, Congcong Huo, Yubo Fan, Zengyong Li, Zulin Dou
Summary: This study investigated the specific effects of low-frequency (LF) and high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) on cortical functional network and the process of neural regulation in stroke patients. The results showed that LF-rTMS can activate certain brain regions and continuously regulate functional networks, while HF-rTMS did not induce significant neurovascular coupling response.
Article
Neurosciences
Morris Vanegas, Miguel Mireles, Qianqian Fang
Summary: This study aims to create a systematic software platform for the design, characterization, and comparison of modular fNIRS probes. It provides examples of how parameters such as module shape, orientation, and spatial layout can affect probe performance, offering a new approach for the fNIRS user community to address the challenging problem of module and probe parameter selection and fine-tuning.
Article
Integrative & Complementary Medicine
Yuan Jie, Zheng Zhong, Cao Yue, Chen Jie, Li Yuan-yuan, Lei Ya-ling
Summary: This study investigated the effect of low-frequency magnetic stimulation at Shenmen (HT 7) acupoint on blood oxygen levels in the prefrontal cortex of healthy subjects using fNIRS technology. The results showed a decrease in blood oxygen concentration during the stimulation period, with significant differences observed in the recovery period.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Clinical Neurology
Vidhya Vijayakrishnan Nair, Brianna R. Kish, Ho-Ching (Shawn) Yang, Zhenyang Yu, Hang Guo, Yunjie Tong, Zhenhu Liang
Summary: This study aims to develop a comprehensive multimodal anesthesia depth monitor by understanding the neural and hemodynamic responses during general anesthesia using fNIRS and EEG. The research found a significant decrease in the complexity and power of fNIRS signals during the maintenance phase of anesthesia and variations in responses to anesthesia between adults and children. Multimodal approach could provide a reliable measure of anesthesia depth, taking into account specific differences between age groups.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Psychiatry
Dorothea L. Floris, Han Peng, Varun Warrier, Michael V. Lombardo, Charlotte M. Pretzsch, Clara Moreau, Alex Tsompanidis, Weikang Gong, Maarten Mennes, Alberto Llera, Daan van Rooij, Marianne Oldehinkel, Natalie J. Forde, Tony Charman, Julian Tillmann, Tobias Banaschewski, Carolin Moessnang, Sarah Durston, Rosemary J. Holt, Christine Ecker, Flavio Dell'Acqua, Eva Loth, Thomas Bourgeron, Declan G. M. Murphy, Andre F. Marquand, Meng-Chuan Lai, Jan K. Buitelaar, Simon Baron-Cohen, Christian F. Beckmann
Summary: Using deep learning on brain images, the authors found that both autistic males and females tend to have neuroanatomy more similar to males, as well as social cognitive features and gene expression patterns associated with male characteristics. These neurophenotypes provide important insights into the biological mechanisms underlying autism.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Iva Ilioska, Marianne Oldehinkel, Alberto Llera, Sidhant Chopra, Tristan Looden, Roselyne Chauvin, Daan Van Rooij, Dorothea L. Floris, Julian Tillmann, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Eva Loth, Tony Charman, Declan G. M. Murphy, Christine Ecker, Maarten Mennes, Christian F. Beckmann, Alex Fornito, Jan K. Buitelaar
Summary: This study found a brainwide pattern of hypo- and hyperconnectivity in individuals with autism, primarily affecting sensory and higher-order attention networks, as well as the default mode network and subcortex. These connectivity alterations were stable and trait-like features of autism, independent of age and sex, and correlated with social difficulties, restrictive and repetitive behaviors, and alterations in sensory processing.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Sarah Baumeister, Carolin Moessnang, Nico Bast, Sarah Hohmann, Pascal Aggensteiner, Anna Kaiser, Julian Tillmann, David Goyard, Tony Charman, Sara Ambrosino, Simon Baron-Cohen, Christian Beckmann, Sven Bolte, Thomas Bourgeron, Annika Rausch, Daisy Crawley, Flavio Dell'Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Dorothea L. Floris, Vincent Frouin, Hannah Hayward, Rosemary Holt, Mark H. Johnson, Emily J. H. Jones, Meng-Chuan Lai, Michael Lombardo, Luke Mason, Bethany Oakley, Marianne Oldehinkel, Antonio M. Persico, Antonia San Jose Caceres, Thomas Wolfers, Eva Loth, Declan G. M. Murphy, Jan K. Buitelaar, Heike Tost, Andreas Meyer-Lindenberg, Tobias Banaschewski, Daniel Brandeis
Summary: This study aimed to assess reward processing in individuals with autism spectrum disorder (ASD) in response to social and monetary rewards. The results showed that individuals with ASD exhibited hypoactivation in the right ventral striatum during reward anticipation compared to typically developing participants. However, there was no significant hyperactivation during the delivery of rewards. These findings do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Viola Hollestein, Geert Poelmans, Natalie J. Forde, Christian F. Beckmann, Christine Ecker, Caroline Mann, Tim Schaefer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G. M. Murphy, Nicolaas A. Puts, Julian Tillmann, Tony Charman, Emily J. H. Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Boelte, Jan K. Buitelaar, Jilly Naaijen
Summary: The E/I imbalance hypothesis suggests that the imbalance between excitatory and inhibitory mechanisms underlies the behavioral characteristics of autism. This study used innovative analysis methods to investigate the relationships between genetic variance, brain structure, and autism symptomatology. The results suggest complex relationships between E/I-related genetics and autism symptom profiles as well as brain structure alterations.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Jannath K. Begum-Ali, Louisa Gosse, Luke Mason, Greg Pasco, Tony H. Charman, Mark Johnson, Emily J. H. Jones
Summary: Children with neurodevelopmental disorders, such as ASD and ADHD, frequently experience sleep disturbances. A study conducted on infants with family history of ASD and/or ADHD revealed that infants with first-degree relatives with ASD showed poorer night sleep quality at 14 months. Poor infant sleep quality was associated with later ASD diagnosis, decreased cognitive ability, increased ASD symptoms, and developing social attention.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Charlotte Pretzsch, Dorothea Floris, Tim V. Schaefer, Anke H. Bletsch, Caroline Gurr, Michael Lombardo, Chris Chatham, Julian Tillmann, Tony Charman, Martina Arenella, Emily Jones, Sara Ambrosino, Thomas S. Bourgeron, Guillaume Dumas, Freddy Cliquet, Claire K. Leblond, Eva Loth, Bethany F. Oakley, Jan M. Buitelaar, Simon Baron-Cohen, Christian Beckmann, Antonio M. Persico, Tobias Banaschewski, Sarah Durston, Christine Freitag, Declan G. M. Murphy, Christine Ecker
Summary: Individuals with autism spectrum disorder show significant variation in clinical outcomes, which is crucial to understand for developing precision-medicine approaches. This study found that distinct neuroanatomical and genetic profiles are associated with different adaptive behavior changes in autistic individuals, suggesting potential targets for interventions.
MOLECULAR PSYCHIATRY
(2023)
Article
Genetics & Heredity
Nico Bast, Luke Mason, Christine Ecker, Sarah Baumeister, Tobias Banaschewski, Emily J. H. Jones, Declan G. M. Murphy, Jan Buitelaar, Eva P. Loth, Gahan M. Pandina, Christine M. Freitag
Summary: The study investigates the relationship between altered functioning of the locus coeruleus-norepinephrine system (LC-NE) and attenuated social attention in individuals with autism spectrum disorder (ASD). The findings suggest that LC-NE activity modulates sensory salience processing and contributes to the differences in social attention observed in ASD. This study provides valuable insights into the underlying mechanisms of ASD.
Article
Behavioral Sciences
John E. Richards, Maggie W. Guy, Abigail L. Hogan, Jane E. Roberts
Summary: This study examined the patterns of event-related potential responses during a face processing task in groups of preschoolers uniquely impacted by autism spectrum disorder (ASD), including children with ASD, children with fragile X syndrome (FXS), children with familial risk for ASD but without a diagnosis (ASIBs), and a low-risk control (LRC) group. The results showed that the FXS group had larger ERP components compared to the other groups, while the ASD and ASIB groups showed smaller responses for specific stimuli. The similarity of the ASD and ASIB responses suggested a common genetic or environmental origin for the reduced response.
Review
Biochemistry & Molecular Biology
Valeria Parlatini, Takashi Itahashi, Yeji Lee, Siwei Liu, Thuan T. Nguyen, Yuta Y. Aoki, Stephanie J. Forkel, Marco Catani, Katya Rubia, Juan H. Zhou, Declan G. Murphy, Samuele Cortese
Summary: This study conducted a systematic review and meta-analysis of diffusion weighted imaging (DWI) studies to investigate abnormal anatomical brain connections in ADHD. The findings show white matter alterations in projection, commissural and association pathways, especially reduced fractional anisotropy (FA), which are associated with symptom severity and cognitive deficits. Despite some methodological limitations, these findings have important implications for understanding the brain effects of ADHD and guiding clinical interventions.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Bethany Oakley, Charlotte Boatman, Sophie Doswell, Antonia Dittner, Andrew Clarke, Ann Ozsivadjian, Rachel Kent, Adrian Judd, Saffron Baldoza, Amy Hearn, Declan Murphy, Emily Simonoff, Molehill Mountain Advisory Group
Summary: Up to 50% of autistic individuals experience anxiety, and developing interventions to improve anxiety has been identified as a priority. However, there are limited evidence-based therapies targeted towards anxiety in autistic individuals. This study aims to assess the feasibility and acceptability of an app-based therapeutic approach called "Molehill Mountain", which is adapted for autistic individuals and utilizes recommended CBT approaches. The trial will enroll approximately 100 participants and assess various outcomes, including app acceptability, anxiety symptoms, and medication and service use. The findings will inform future optimization and implementation of "Molehill Mountain" to improve mental health outcomes for autistic adults.
Article
Genetics & Heredity
Lisa M. Berg, Caroline Gurr, Johanna Leyhausen, Hanna Seelemeyer, Anke Bletsch, Tim Schaefer, Charlotte M. Pretzsch, Bethany Oakley, Eva Loth, Dorothea L. Floris, Jan K. Buitelaar, Christian F. Beckmann, Tobias Banaschewski, Tony Charman, Emily J. H. Jones, Julian Tillmann, Chris H. Chatham, Thomas Bourgeron, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Simon Baron-Cohen, Sarah Baumeister, Sven Boelte, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Daisy Crawley, Flavio Dell'Acqua, Guillaume Dumas, Sarah Durston, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Mark H. Johnson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'Ardhuy, Michael V. Lombardo, David J. Lythgoe, Rene Mandl, Andre Marquand, Luke Mason, Maarten Mennes, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Bast, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jose Caceres, Emily Simonoff, Will Spooren, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge, Marcel P. Zwiers, Declan G. Murphy, Christine Ecker
Summary: This study investigates the neurobiology of individuals with autism spectrum disorders (ASD) and their co-occurring condition, attention-deficit/hyperactivity disorder (ADHD). The findings suggest that the neuroanatomy of ASD is significantly modulated by ADHD, indicating that individuals with co-occurring ADHD may have specific neuroanatomical underpinnings potentially mediated by atypical gene expression.
Article
Psychiatry
Qiyun Huang, Hester Velthuis, Andreia C. Pereira, Jumana Ahmad, Samuel F. Cooke, Claire L. Ellis, Francesca M. Ponteduro, Nicolaas A. J. Puts, Mihail Dimitrov, Dafnis Batalle, Nichol M. L. Wong, Lukasz Kowalewski, Glynis Ivin, Eileen Daly, Declan G. M. Murphy, Grainne M. Mcalonan
Summary: This study evaluated the role of GABA in auditory repetition suppression in individuals with autism spectrum disorder (ASD). The results showed weaker suppression of auditory responses in individuals with ASD, but this suppression could be reversed by treatment with arbaclofen, a GABA receptor agonist. These findings suggest that GABA dysfunction contributes to alterations in auditory sensory processing in ASD and targeting GABA activity may be a potential therapeutic approach.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Valeria Parlatini, Joaquim Radua, Aleix Solanes Font, Rob Wichers, Stefanos Maltezos, Masafumi Sanefuji, Flavio Dell'Acqua, Marco Catani, Michel Thiebaut de Schotten, Declan Murphy
Summary: This longitudinal study found an association between pre-treatment anatomy of the fronto-striatal and fronto-parietal attentional networks and methylphenidate (MPH) treatment response in adults. Specifically, a smaller left dorsal superior longitudinal fasciculus (SLF I) was associated with a lower probability of responding to two-month MPH treatment. Only non-responders significantly differed from controls in this tract metric. Additionally, machine learning identified clinical and neuropsychological factors associated with treatment response.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Immunology
Martina Arenella, Giuseppe Fanelli, Lambertus A. Kiemeney, Grainne Mcalonan, Declan G. Murphy, Janita Bralten
Summary: Autism spectrum disorder (ASD) is a common and complex neurodevelopmental condition. The pathophysiology of ASD is poorly defined, but a strong genetic component and immune dysregulation are believed to play a role. This study found a positive correlation between ASD and allergic diseases (ALG), but negative correlations with lymphocyte count, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Additionally, specific genetic loci related to RA, C-reactive protein, and granulocytes and lymphocyte counts were found to be correlated with ASD. In the general population, increased genetic liability for SLE, RA, ALG, and lymphocyte levels was associated with autistic traits, particularly rigidity and childhood behavior.
BRAIN BEHAVIOR & IMMUNITY-HEALTH
(2023)
Article
Anatomy & Morphology
Stefano Sandrone, Marco Aiello, Carlo Cavaliere, Michel Thiebaut de Schotten, Katja Reimann, Claire Troakes, Istvan Bodi, Luis Lacerda, Serena Monti, Declan Murphy, Stefan Geyer, Marco Catani, Flavio Dell'Acqua
Summary: The histological validity of T1w/T2w myelin mapping in white matter was explored by comparing it with ex vivo postmortem histology and in vivo MRI methods (QSM and multi-echo T2 MWF mapping techniques). The results show a discrepancy between T1w/T2w myelin maps and histology, suggesting caution in using T1w/T2w as a white matter mapping method at the callosal level.
BRAIN STRUCTURE & FUNCTION
(2023)
