Review
Clinical Neurology
Norma Angelica Labra Ruiz, Daniel Santamaria Del Angel, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Hugo Juarez Olguin, Monica Punzo Soto, David Calderon Guzman
Summary: The communication pathway between the immune and neuroendocrine systems in MDD has been identified as a key factor in the cognitive and executive dysfunction seen in patients, suggesting potential therapeutic options for the disease.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Po-Han Chou, Wen-Chun Liu, Shao-Cheng Wang, Wei-Hao Lin, Yi-Lun Chung, Chun-Hung Chang, Kuan-Pin Su
Summary: This study examines the effects of repetitive transcranial magnetic stimulation (rTMS) on the left dorsolateral prefrontal cortex (DLPFC) in patients with major depressive disorder (MDD) using near infrared spectroscopy (NIRS) to measure frontal lobe activity. The results show that an increase in frontal lobe activity is significantly correlated with improvements in depressive symptoms after 10 and 20 rTMS sessions. These findings suggest that NIRS could serve as a biomarker for monitoring treatment response in MDD patients undergoing rTMS.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Ji Zhou, Sebastian Hormigo, Muhammad S. Sajid, Manuel A. Castro-Alamancos
Summary: Conflicting goals can affect actions, but the same action can have different consequences depending on the situation. In a study with mice, adding a rule that punishes unsignaled actions delayed the timing of signaled actions, indicating increased caution. Caution was influenced by task signaling, contingency, and reinforcement type. Interestingly, caution persisted in avoidance motivated by danger but was only temporary in approach motivated by reward. Caution developed independently of the frontal cortex or basal ganglia output circuits.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Chiara Spironelli, Francesca Fusina, Marco Bortolomasi, Alessandro Angrilli
Summary: This study aimed to differentiate characteristics and differences among patients with bipolar disorder, major depressive disorder, and persistent depressive disorder using frontal EEG asymmetry as an index. The results found that persistent depressive disorder patients exhibited greater clinical and neurophysiological impairments compared to major depressive disorder patients. Additionally, differences in frontal beta activity asymmetry were observed among the three groups, with persistent depressive disorder and major depressive disorder groups showing lower bilateral frontal beta activity compared to the bipolar disorder group. Results were interpreted considering both clinical and neurophysiological domains.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinghe Li, Fanghui Dong, Qun Gai, Kaili Che, Heng Ma, Feng Zhao, Tongpeng Chu, Ning Mao, Peiyuan Wang
Summary: Machine-learning models combined with multisequence MRI neuroimaging features significantly improve the diagnosis of major depressive disorder and accurately predict suicide risk in patients with MDD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Psychology, Clinical
Scott A. Wilke, Crystal L. Johnson, Juliana Corlier, Katharine G. Marder, Andrew C. Wilson, Christopher M. Pleman, Andrew F. Leuchter
Summary: MDD patients taking psychostimulant medication show greater clinical improvement during rTMS treatment, particularly in sleep and mood/cognition. There are no significant differences among different drug categories, and the clinical efficacy of some medications may be dose-dependent.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Xiang Lu, Jian-Feng Zhang, Feng Gu, Hong-Xing Zhang, Meng Zhang, Hai-San Zhang, Rui-Ze Song, Ya-Chen Shi, Kun Li, Bi Wang, Zhi-Jun Zhang, Georg Northoff
Summary: The study revealed a significant reduction in task-related global signal correlation in the default-mode network (DMN) of patients with major depressive disorder (MDD) specifically during fast processing of negative emotions, suggesting a link with psychomotor retardation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Michael K. Yeung
Summary: This article provides a systematic review of fNIRS studies on brain function in children and adolescents, evaluating methodological aspects such as research design, experimental paradigm, fNIRS measurement, data preprocessing, statistical analysis, and result presentation. It also includes a qualitative synthesis of study findings on the effects of age and other factors on changes in oxyhemoglobin concentration.
Article
Psychiatry
Zhaoyuan Tu, Feng Wu, Xiaowei Jiang, Lingtao Kong, Yanqing Tang
Summary: This research aimed to explore gender differences in brain function images in MDD, finding specific patterns and diagnostic differences in male and female patients with MDD. The occipital lobe, calcarine, DLPFC, and DCG were identified as main different brain regions between male and female patients, potentially serving as biomarkers for diagnosing and treating MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Hannah Lemke, Lina Romankiewicz, Katharina Foerster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinstraeter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
Summary: This study investigates the association between disease course in Major Depressive Disorder (MDD) and brain structural alterations. The results suggest that a more severe and chronic disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Rubai Zhou, Jun Chen, Guoqing Zhao, Zuowei Wang, Daihui Peng, Weiping Xia, Ruizhi Mao, Jingjing Xu, Fan Wang, Chen Zhang, Yong Wang, Chengmei Yuan, Yousong Su, Jia Huang, Tao Yang, Chenglei Wang, Lvchun Cui, Jijun Wang, Lena Palaniyappan, Yiru Fang
Summary: The study identified a link between greater GM volume in the right parahippocampal gyrus and higher social function in patients with MDD. Even with improved overall social function over 12 weeks, there were continued differences in social function between high and low-functioning subgroups.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychiatry
Lan Hu, Hui He, Neil Roberts, Jiajia Chen, Guojian Yan, Li Pu, Xufeng Song, Cheng Luo
Summary: Interoception plays an important role in maintaining bodily homeostasis and promoting survival, and dysfunction of interoception is commonly observed in individuals with Major Depressive Disorder (MDD). Neuroimaging studies have revealed alterations in the structure and function of the insula, a major brain structure involved in interoception, in individuals with depression, but the precise relationship between these alterations and interoceptive dysfunction is still unclear. This review aims to examine the evidence of interoceptive dysfunction in people with MDD and the specific alterations in insular structure and function revealed by neuroimaging.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Zhihui Lan, Wei Zhang, Donglin Wang, Zhonglin Tan, Yan Wang, Chenyuan Pan, Yang Xiao, Changxiao Kuai, Shao-Wei Xue
Summary: This study investigates the characteristics of network dysfunction in major depressive disorder (MDD). It finds that MDD patients have lower modular segregation in the frontal-parietal network (FPN) and abnormal inter-module connections between the FPN and other brain regions. The study also discovers larger participation coefficients in certain brain regions of MDD patients, which are negatively correlated with depression severity.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Victor De la Pena-Arteaga, Mercedes Berruga-Sanchez, Trevor Steward, Ignacio Martinez-Zalacain, Ximena Goldberg, Agustina Wainsztein, Carolina Abulafia, Narcis Cardoner, Mariana N. Castro, Mirta Villarreal, Jose M. Menchon, Salvador M. Guinjoan, Carles Soriano-Mas
Summary: This study identified a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, while also observing disorder-specific alterations. In MDD, there is a primary deficit in prefrontal activations, while BPD is defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate the different profiles of emotion regulation alterations observed in these disorders in neurobiological terms.
EUROPEAN PSYCHIATRY
(2021)
Article
Neurosciences
Neil Cleland, Samuel Lieblich, Martin Schalling, Christoffer Rahm
ACTA NEUROPSYCHIATRICA
(2015)
Article
Neurosciences
Christoffer Rahm, Benny Liberg, Greg Reckless, Olga Ousdal, Ingrid Melle, Ole A. Andreassen, Ingrid Agartz
ACTA NEUROPSYCHIATRICA
(2015)
Article
Neurosciences
Neil Cleland, Samuel Lieblich, Martin Schalling, Christoffer Rahm
ACTA NEUROPSYCHIATRICA
(2015)
Article
Neurosciences
Christoffer Rahm, Benny Liberg, Greg Reckless, Olga Ousdal, Ingrid Melle, Ole A. Andreassen, Ingrid Agartz
ACTA NEUROPSYCHIATRICA
(2015)
Review
Medicine, General & Internal
Benny Liberg, Christoffer Rahm, Anita Panayiotou, Christos Pantelis
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Psychiatry
Valdemar Landgren, Kinda Malki, Matteo Bottai, Stefan Arver, Christoffer Rahm
Letter
Psychiatry
Christoffer Rahm, Valdemar Landgren, Stefan Arver
Article
Psychiatry
Christoph Abe, Roberth Adebahr, Benny Liberg, Christian Mannfolk, Alexander Lebedev, Jonna Eriksson, Niklas Langstrom, Christoffer Rahm
Summary: This study quantified neurobiological and clinical correlates of Pedophilic disorder (PD) by comparing PD patients with healthy controls, revealing psychiatric comorbidity, neurodevelopmental abnormalities, and cognitive correlates in PD individuals. These findings suggest that neurodevelopmental mechanisms are involved in PD and should be considered in the future clinical management of PD patients.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Review
Pharmacology & Pharmacy
Valdemar Landgren, Josephine Savard, Cecilia Dhejne, Jussi Jokinen, Stefan Arver, Michael C. Seto, Christoffer Rahm
Summary: Guidelines for the pharmacological treatment of paraphilic disorders have been mainly based on data from forensic settings and risk levels for sexual crime. However, emerging treatment options are being evaluated, targeting individuals experiencing distress because of their sexual urges and preferences. Some studies suggest that testosterone-lowering drugs may reduce sexual activity for patients with paraphilic disorders, but the evidence is limited.
Article
Psychology, Clinical
Gokce Bayram, Allison McMahan, Niklas Juth, Christoffer Rahm
Summary: In recent years, there has been a shift in the view on pedophilia and its treatment. This study investigates the opinions of healthcare professionals on some debated topics and finds a lack of consensus, revealing a gap between international expert agreements and clinical practice.
SEXUAL AND RELATIONSHIP THERAPY
(2023)
Meeting Abstract
Neurosciences
Josephine Savard, Tatja Hirvikoski, Katarina Gorts Oberg, Cecilia Dhejne, Christoffer Rahm, Jussi Jokinen
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Felix Wiffstrom, Niklas Langstrom, Valdemar Landgren, Christoffer Rahm
FRONTIERS IN PSYCHOLOGY
(2020)
Letter
Psychology, Clinical
Allison McMahan, Charlotte Sparre, Elin Soderquist, Stefan Arver, Gerhard Andersson, Viktor Kaldo, Katarina Gorts-Oberg, Christoffer Rahm
ARCHIVES OF SEXUAL BEHAVIOR
(2020)
Meeting Abstract
Neurosciences
Cassandra M. J. Wannan, Cali F. Bartholomeusz, Ian Everall, Christoffer Rahm, Samuel Lieblich, Christina Phassouliotis, Cropley Vanessa, Christos Pantelis
BIOLOGICAL PSYCHIATRY
(2016)
