Article
Nutrition & Dietetics
Adrian Montes-de-Oca-Garcia, Alejandro Perez-Bey, Juan Corral-Perez, Alberto Marin-Galindo, Maria Calderon-Dominguez, Daniel Velazquez-Diaz, Cristina Casals, Jesus G. G. Ponce-Gonzalez
Summary: This cross-sectional study aimed to investigate the effects of plasma leptin on fat oxidation in young adults, considering sex differences and the mediating role of fatness and cardiorespiratory fitness. Results showed that in men, leptin was negatively associated with maximal fat oxidation and positively associated with insulin secretion. In women, leptin was positively associated with resting fat oxidation and insulin sensitivity, and negatively associated with maximal fat oxidation. The association between leptin and fat oxidation was mediated by cardiorespiratory fitness.
Article
Multidisciplinary Sciences
Jose Miguel Rodriguez-Lopez, Manuel Lachica, Lucrecia Gonzalez-Valero, Ignacio Fernandez-Figares
Summary: The study measured metabolic responses to glucose infusion in Iberian and Landrace pigs, showing that Iberian pigs had higher levels of insulin, lactate, triglycerides, and urea, while lower levels of glucose, creatinine, and cholesterol compared to Landrace pigs. The results suggest that growing Iberian pigs may exhibit early signs of insulin resistance.
Review
Endocrinology & Metabolism
Rosa Isela Ortiz-Huidobro, Myrian Velasco, Carlos Larque, Rene Escalona, Marcia Hiriart
Summary: The rise in obesity, particularly among women, is linked to insulin resistance in adipose tissue, a critical factor in metabolic diseases. Understanding the sexual dimorphism in molecular mechanisms of insulin actions is essential for developing targeted therapeutic strategies and public health policies to address obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Virginia Boccardi, Francesca Mancinetti, Marta Baroni, Roberta Cecchetti, Patrizia Bastiani, Carmelinda Ruggiero, Patrizia Mecocci
Summary: The study found that plasma levels of EGF, Eotaxin, and MCP-1 are closely associated with insulin resistance in women, with BMI being a significant mediator. This suggests that the association between cytokines and insulin resistance is gender-specific.
Review
Endocrinology & Metabolism
Jingyue Zhang, Yingming Zhang, Ze Ren, Dongmei Yan, Guiying Li
Summary: This review focuses on the role of TRIM family in metabolic associated fatty liver disease, summarizing their regulation in the occurrence and development of the disease as well as insulin resistance. The potential of TRIM proteins as targets for the treatment of metabolic associated fatty liver disease is also discussed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Sadaf Dabeer, Sheikh Raisuddin
Summary: This study examined the intergenerational effect of parental exposure to an environmentally relevant dose of BPA on the hepatic health outcome of their offspring in a metabolically challenged population. The results showed that BPA exposure led to increased birth weight and rapid weight gain in the offspring, along with changes in liver function enzymes, histological changes in the liver tissue, and the onset of non-alcoholic fatty liver disease (NAFLD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carolina Panzarin, Lais Angelica de Paula Simino, Mariana Camargo Silva Mancini, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: The modulation of hepatic miR-370-122-Let7 miRNA may play a crucial role in the early stages of NAFLD, preceding changes in glycemic homeostasis and adiposity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Patricia Perez-Matute, Iciar P. Lopez, Maria iniguez, Emma Recio-Fernandez, Raquel Torrens, Sergio Pineiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, Jose A. Oteo, Jose G. Pichel
Summary: This study aims to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. The results showed that young IGF1R-deficient mice were insulin-resistant and had altered circulating levels of IGF1, growth hormone (GH), and IGFBP3. Middle-aged IGF1R-deficient male mice were able to counteract the negative effects induced by aging and high-fat diet (HFD) in adiposity, inflammation, and glucose metabolism, demonstrating a metabolic sexual dimorphism dependent on IGF1R.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Wen Liu, Min Zhu, Meng Gong, Wen Zheng, Xin Zeng, Qing Zheng, Xiaoyu Li, Fudong Fu, Yingyi Chen, Jingqiu Cheng, Zhiyong Rao, Yanrong Lu, Younan Chen
Summary: Obesity is a global epidemic and excess saturated fatty acids (SFAs) contribute to metabolic diseases. Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have protective effects against SFA-induced cellular damage. In this study, both MUFA-enriched and PUFA-enriched diets improved liver health in obese mice, but PUFA intake led to increased oxidative stress. Liver lipidomic analysis showed differences in lipid metabolites between the two diets. These findings suggest that MUFA and PUFA have distinct effects on lipid metabolism and can impact the development of metabolic diseases.
Article
Nutrition & Dietetics
Savanie Fernando, Jacob Sellers, Shauri Smith, Sarayu Bhogoju, Sadie Junkins, Morgan Welch, Orion Willoughby, Nabin Ghimire, Cassandra Secunda, Marina Barmanova, Sean C. Kumer, Kisuk Min, Ahmed Lawan
Summary: This study reveals the upregulation of MKP-2 in liver tissue of obese and fatty liver disease patients and in insulin-responsive tissues of obese mice. MKP-2 deficiency in mice protects against diet-induced obesity and hepatic steatosis and is accompanied by improved glucose homeostasis and insulin sensitivity.
Review
Endocrinology & Metabolism
Milian Chen, Ying Cao, Guang Ji, Li Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) has become a common chronic liver disease worldwide. It is commonly associated with obesity, but can also occur in lean individuals, known as lean NAFLD. Lean NAFLD is often accompanied by sarcopenia, progressive loss of muscle mass and quality. The pathological features of lean NAFLD contribute to the development of sarcopenia, while sarcopenia further exacerbates ectopic fat accumulation and lean NAFLD. In this review, we discuss the association between sarcopenia and lean NAFLD, summarize the underlying pathological mechanisms, and suggest potential strategies to reduce the risks of lean NAFLD and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Shuhua Tian, Yunfan Wang, Xiangfei Li, Jie Liu, Jing Wang, Yingjian Lu
Summary: Sulforaphane (SFN) can alleviate obesity complications through various mechanisms, including reducing NAFLD, inflammation, oxidative stress, adipose tissue hypertrophy, and insulin resistance, as well as regulating glucose and lipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Anais Alves, Frederic Lamarche, Remy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stephanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J. P. Rautureau, Baptiste Panthu, Beatrice Morio
Summary: The interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which leads to disruption of the insulin signaling pathway. The plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Glycine supplementation can promote MAM integrity and improve insulin response in hepatocytes, but it does not have a beneficial effect on the overall metabolic profile in obese mice.
Review
Biochemistry & Molecular Biology
Morgan Welch, Cassandra Secunda, Nabin Ghimire, Isabel Martinez, Amber Mathus, Urja Patel, Sarayu Bhogoju, Mashael Al-Mutairi, Kisuk Min, Ahmed Lawan
Summary: Obesity is a global epidemic that affects the development of metabolic diseases such as fatty liver disease. Membrane lipids play important roles in lipid homeostasis and are implicated in the pathogenesis of fatty liver disease. Recent studies using genetic and pharmacological mouse models have provided insights into the role of lipid species in various mechanisms/pathways related to fatty liver disease.
Review
Gastroenterology & Hepatology
Fu-Rong Sun, Bing-Yuan Wang
Summary: The diagnosis of metabolic-associated fatty liver disease is independent of alcohol intake, as alcohol and its metabolites can affect metabolic abnormalities. Some studies suggest that light to moderate alcohol consumption may improve metabolic function.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Iranzu Gomez de Segura, Patricia Ahechu, Javier Gomez-Ambrosi, Amaia Rodriguez, Beatriz Ramirez, Sara Becerril, Xabier Unamuno, Amaia Mentxaka, Jorge Baixauli, Victor Valenti, Rafael Moncada, Camilo Silva, Gema Fruhbeck, Victoria Catalan
Summary: Obesity and colon cancer significantly decreased MFAP2 gene expression levels in VAT, while an opposite trend was observed in TGFB1 mRNA levels. Stimulation of HT-29 cells with LPS and IL-4 increased MFAP2 mRNA levels, while treatment with CoCl2 led to downregulation. MAGP-1 treatment enhanced the expression of ECM-remodelling genes and reduced the expression levels of COX2/PTGS2 in CC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodriguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernandez-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cunarro, Maria D. P. Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begona Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Muller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel Lopez, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueiras
Summary: The O-GlcNAcylation of p53 in the liver plays a crucial role in the physiological regulation of glucose homeostasis by controlling the expression of phosphoenolpyruvate carboxykinase.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Marina Martin, Amaia Rodriguez, Javier Gomez-Ambrosi, Beatriz Ramirez, Sara Becerril, Victoria Catalan, Miguel Lopez, Carlos Dieguez, Gema Fruhbeck, Maria A. Burrell
Summary: Restriction of high-fat diet intake can lead to weight loss and reduced adiposity, as well as improved metabolism; normalization of hypothalamic NPY, AgRP and POMC expression may play a role in this process.
Article
Engineering, Biomedical
Xabier Unamuno, Javier Gomez-Ambrosi, Sara Becerril, Francisco Javier Alvarez-Cienfuegos, Beatriz Ramirez, Amaia Rodriguez, Silvia Ezquerro, Victor Valenti, Rafael Moncada, Amaia Mentxaka, Marcos Llorente, Camilo Silva, Maria de Los Reyes Elizalde, Victoria Catalan, Gema Fruhbeck
Summary: This study investigates the impact of weight loss achieved through bariatric surgery (BS) and caloric restriction (CR) on the biomechanical properties of adipose tissue (AT). The results show that BS, but not CR, changes the biomechanical properties of AT and is associated with metabolic improvements. Gene expression levels and blood vessel density were found to be altered in AT after BS, which contributed to changes in the tissue's biomechanical properties.
ACTA BIOMATERIALIA
(2022)
Review
Nutrition & Dietetics
Victoria Catalan, Iciar Aviles-Olmos, Amaia Rodriguez, Sara Becerril, Jose Antonio Fernandez-Formoso, Dimitrios Kiortsis, Piero Portincasa, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: The main causes of the obesity epidemic are genetics and overnutrition, along with a decline in physical activity. However, there may be other factors, referred to as the exposome, that contribute to obesity. Broad interventions are needed to better identify and understand these factors.
Article
Immunology
Gema Fruehbeck, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Sara Becerril, Amaia Rodriguez, Rafael Moncada, Jorge Baixauli, Camilo Silva, Javier Escalada, Javier Gomez-Ambrosi
Summary: The study compared IL-1RA levels in individuals with different weight statuses and analyzed its association with adipose tissue dysfunction. The results showed a significant increase in IL-1RA levels in individuals with obesity, particularly in the group associated with impaired glucose tolerance and type 2 diabetes. IL1RN mRNA expression in adipose tissue also increased, correlating with the expression of inflammation-related genes.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Victoria Catalan, Paula Domench, Javier Gomez-Ambrosi, Beatriz Ramirez, Sara Becerril, Amaia Mentxaka, Amaia Rodriguez, Victor Valenti, Rafael Moncada, Jorge Baixauli, Camilo Silva, Javier Escalada, Gema Fruhbeck
Summary: Dysfunctional adipose tissue in obesity leads to chronic inflammation and altered extracellular matrix remodeling, promoting cancer development. This study investigates the role of dermatopontin (DPT) in the development of obesity-associated colon cancer. The results suggest that DPT expression levels are decreased in patients with colon cancer, but increased in visceral adipose tissue. Inflammatory factors enhance DPT expression and DPT affects the expression of extracellular matrix proteins. These findings imply a possible involvement of DPT in obesity-associated colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sara Becerril, Carlota Tuero, Javier A. Cienfuegos, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Xabier Unamuno, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: This study compares Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SADI-S) in obese rats and finds that SADI-S surgery results in better control of lipid and glucose metabolism and improved adipose tissue function compared to SG surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Amaia Mentxaka, Javier Gomez-Ambrosi, Beatriz Ramirez, Amaia Rodriguez, Sara Becerril, Gabriela Neira, Victor Valenti, Rafael Moncada, Camilo Silva, Xabier Unamuno, Javier A. Cienfuegos, Javier Escalada, Gema Fruhbeck, Victoria Catalan
Summary: This study found that circulating levels of Netrin-1 (NTN-1) were increased in obese individuals and decreased after weight loss. The expression levels of NTN-1 and its receptor, NEO1, were upregulated in visceral adipose tissue (VAT) from obese patients. In vitro studies showed that NTN-1 expression was enhanced under hypoxia and by inflammatory factors in adipocytes and macrophages. Additionally, treatment of adipocytes with NTN-1 promoted the upregulation of pro-inflammatory and chemotactic molecules. These findings suggest that NTN-1 plays a role in VAT chronic inflammation and insulin resistance in obesity.
Review
Biochemistry & Molecular Biology
Carlota Tuero, Sara Becerril, Silvia Ezquerro, Gabriela Neira, Gema Fruhbeck, Amaia Rodriguez
Summary: The development of nonalcoholic fatty liver disease (NAFLD) is complex and multifactorial, with ghrelin playing a significant role. Ghrelin, a gut hormone, regulates appetite and adiposity. It targets the liver and regulates pathways related to lipid metabolism, inflammation, and fibrosis. Altered ghrelin levels are observed in patients with metabolic diseases, which are known risk factors for NAFLD. This review highlights the mechanisms by which ghrelin protects the liver, including reducing hepatocyte lipotoxicity, promoting autophagy and fatty acid β-oxidation, improving mitochondrial dysfunction, decreasing inflammation, and inactivating hepatic stellate cells. The regulation of metabolic and inflammatory pathways in the liver suggests that ghrelin could be a potential therapeutic target for preventing NAFLD in patients with metabolic disorders.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Oncology
Amaia Mentxaka, Javier Gomez-Ambrosi, Gabriela Neira, Beatriz Ramirez, Sara Becerril, Amaia Rodriguez, Victor Valenti, Rafael Moncada, Jorge Baixauli, Maria A. Burrell, Camilo Silva, Vasco Claro, Albert Ferro, Victoria Catalan, Gema Fruhbeck
Summary: This study found that excess visceral adipose tissue in patients with obesity and colon cancer is associated with increased expression levels of NTN-1 and its main receptors, leading to the development of an inflammatory microenvironment that favors colon cancer progression.
Correction
Immunology
G. Fruhbeck, A. Mentxaka, P. Ahechu
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gema Fruhbeck, Leire Mendez-Gimenez, Sara Becerril, Beatriz Ramirez, Ana Wenting Hernandez-Pardos, Javier A. Cienfuegos, Victor Valenti, Rafael Moncada, Victoria Catalan, Javier Gomez-Ambrosi, Ines V. da Silva, Graca Soveral, Amaia Rodriguez
Summary: We investigated the role of AQP7 in the process of BAT whitening and found that its expression is upregulated in diet-induced obesity (DIO). Interestingly, the expression of AQP7 is downregulated after cold exposure or bariatric surgery, which is associated with the improvement of BAT whitening. Furthermore, AQP7 expression is regulated by specific lipogenic signals and correlated with the expression of lipogenic genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Biochemistry & Molecular Biology
Sara Becerril, Javier A. Cienfuegos, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Xabier Unamuno, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: SADI-S is more effective than SG or caloric restriction in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)