Article
Chemistry, Multidisciplinary
J. Y. Quek, E. Uroro, N. Goswami, K. Vasilev
Summary: Bacterial infection remains a leading cause of death globally despite advancements in biomedical sciences and medicine, with the conventional treatment challenged by antibiotics resistance. An exciting direction in the past decade has focused on designing stimuli responsive systems incorporating a wide range of antimicrobial nanomaterials to address current challenges.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bei Ran, Zuokai Wang, Wenlin Cai, Lei Ran, Wenxi Xia, Weijian Liu, Xiaojun Peng
Summary: The use of photo-antimicrobials (PAMs) in phototherapy (PT) offers a new approach to combat multi-drug-resistant pathogens. By reacting with cell membranes, PAMs can effectively eradicate various pathogens, making them suitable for treating local infections, wound dressings, and biofilm removal from medical devices. Further development of organic photo-antimicrobials (OPAMs) is crucial for addressing the general challenges in microbial infections, especially during the global COVID-19 epidemic.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Medicine, General & Internal
Julia Stadelmaier, Isabelle Roux, Maria Petropoulou, Lukas Schwingshackl
Summary: This study aimed to evaluate the bias associated with certain methodological characteristics in nutrition research. The findings suggest that most characteristics may not exaggerate intervention effect estimates, except for trials with subjective outcomes.
Review
Chemistry, Multidisciplinary
Gan Lin, Jiajing Zhou, Hongwei Cheng, Gang Liu
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Article
Chemistry, Medicinal
Qidi Kong, Wei Pan, Heng Xu, Yaru Xue, Bin Guo, Xin Meng, Cheng Luo, Ting Wang, Shuhua Zhang, Yushe Yang
Summary: The novel pyrimido[4,5-b]indole derivative 18r exhibited superior antibacterial activity compared to GP-1, showing improved pharmacokinetic properties and potential for therapeutic use.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Linda B. S. Aulin, Apostolos Liakopoulos, Piet H. van der Graaf, Daniel E. Rozen, J. G. Coen van Hasselt
Summary: Collateral sensitivity-based antibiotic treatments have the potential to limit the emergence of antimicrobial resistance, the efficacy of which depends critically on the design of treatment schedules.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Leonardo Occhiogrosso, Paolo Capozza, Alessio Buonavoglia, Nicola Decaro, Adriana Trotta, Claudia Marin, Marialaura Corrente
Summary: This study aimed to investigate the association of bacteria, including the complex red bacteria (RCB), with Equine Periodontal Disease (EPD), and to evaluate possible EPD risk factors. It was found that Tannerella and Treponema strains were significantly more prevalent in horses affected by EPD, although RCB pathogens were detected in a low number of horses. None of the investigated pathogens were significantly associated with a specific stage of disease severity. Horses aged older than 20 years were at a higher risk of EPD.
Article
Public, Environmental & Occupational Health
Qian Wu, Min Wang, Yu Zhang, Wei Wang, Teng-Fei Ye, Kui Liu, Song-Hua Chen
Summary: This study aimed to evaluate the status of diabetes mellitus (DM) and drug resistance in tuberculosis (TB) patients. The results showed that there was no significant association between DM and TB drug resistance. However, untreated TB patients without DM were more likely to develop poly-drug resistant tuberculosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Wei Zhang, Qing Wang, Liru Zhang, Jiangxiong Wu, Jinlu Liu, Cheng Lu, Xinsheng Wang, Zhihua Zhang
Summary: The purpose of this study was to investigate the epidemiological characteristics of clinically isolated Escherichia coli from 2014 to 2022. The results showed that the carbapenem resistance rates increased over time and the number of isolates also showed an upward trend. It was found that male patients and sputum samples had higher drug resistance rates compared to female patients and urine samples. Carbapenems were still the optimal choice for treating extended spectrum beta-lactamase-producing E. coli infections.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Mulatu Gashaw, Zufan Hailu Marame, Mubarek Abera, Solomon Ali
Summary: This study found significantly higher antibiotic resistance in gut bacteria isolated from patients using psychotropic medications compared to apparently healthy controls, with Escherichia coli showing the most pronounced resistance pattern.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Sabiha Shaik, Arya Suresh, Niyaz Ahmed
Summary: It is crucial to use phenotypically relevant markers for tracking pathogens, including their drug resistance, physiological coordinates, and immune system responses. Multidimensional approaches using diverse data integration, comparative genomics, and functional molecular infection epidemiology are likely successful in tracking MDR pathogens and guiding global infection control strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Gleyce Hellen de Almeida de Souza, Alexandre Ribeiro de Oliveira, Marcelo dos Santos Barbosa, Luana Rossato, Kerly da Silva Barbosa, Simone Simionatto
Summary: This study found that the incidence of secondary multidrug-resistant Gram-negative infection in patients with COVID-19 in Brazil is unclear. A case-control study identified factors associated with the acquisition of multidrug-resistant Gram-negative bacteria (MDR-GNB) in patients with and without COVID-19, and described the mortality rates and clinical features associated with unfavorable outcomes. Among the patients, 926 Gram-negative bacteria were isolated, with 504 being multidrug-resistant, and 73 patients with COVID-19 had secondary MDR-GNB infection. Factors associated with patients' COVID-19-MDR-GNB infections included obesity, heart failure, use of mechanical ventilation, urinary catheter, and previous use of beta-lactams. The study also found higher mortality rates in patients with COVID-19-MDR-GNB compared to the control groups.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Salam Abbara, Didier Guillemot, Christian Brun-Buisson, Laurence Watier
Summary: Antimicrobial resistance is a global health concern, and studies have found that the misuse of antibiotics has led to an increase in resistant infections in communities. Currently, there is heterogeneity in the research on the link between antibiotic use and community-onset resistance infections, highlighting the need for greater standardization in future studies.
Article
Medicine, General & Internal
Dorin Dragos, Maria Iuliana Ghenu, Delia Timofte, Andra-Elena Balcangiu-Stroescu, Dorin Ionescu, Maria Mirabela Manea
Summary: This study aimed to establish cutoff points for presepsin according to the level of kidney dysfunction (KD) in order to avoid overdiagnosis of bacterial infection, overprescription of antibiotics, and risk of bacterial resistance. The study included data from all patients admitted on an emergency basis to two departments of a teaching hospital within a two-year period. The results showed an ascending exponential relationship between presepsin and severity of KD, and different cutoff points should be set for different levels of KD.
Article
Materials Science, Multidisciplinary
Zhicheng Le, Jinming Yu, Ying Jie Quek, Bingyu Bai, Xianlei Li, Yufeng Shou, Ba Myint, Chenjie Xu, Andy Tay
Summary: Microneedles technology is an efficient and minimally invasive method for transdermal delivery of bioactive molecules, avoiding the use of hypodermic needles. It has expanded its applications to non-dermatological purposes and shown promise in biomolecular and cellular sampling for patient health monitoring and disease diagnosis. This review discusses the design principles of microneedles to overcome biological barriers and recent innovations in biomolecular and cellular sampling.
Article
Public, Environmental & Occupational Health
Susan Jain, Kate Clezy, Mary-Louise McLaws
AMERICAN JOURNAL OF INFECTION CONTROL
(2018)
Article
Public, Environmental & Occupational Health
Mary-Louise McLaws, Yell Lee Angela Kwok
AMERICAN JOURNAL OF INFECTION CONTROL
(2018)
Article
Environmental Sciences
Karen File, Thomas Valente, Mary-Louise McLaws
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Gastroenterology & Hepatology
Minh Cuong Duong, Mary-Louise McLaws
JOURNAL OF VIRAL HEPATITIS
(2019)
Article
Public, Environmental & Occupational Health
Susan Jain, Kate Clezy, Mary-Louise McLaws
AMERICAN JOURNAL OF INFECTION CONTROL
(2019)
Article
Ethics
Catherine A. Sharp, Jennifer S. Schulz Moore, Mary-Louise McLaws
JOURNAL OF BIOETHICAL INQUIRY
(2019)
Article
Parasitology
Ngoy Mutombo, Aly Landoure, Wing Young Man, Alan Fenwick, Robert Dembele, Moussa Sacko, Adama D. Keita, Mamadou S. Traore, Joanne P. Webster, Mary-Louise McLaws
Article
Infectious Diseases
Bich Thuy Duong, Minh Cuong Duong, James Campbell, Van Minh Hoang Nguyen, Huu Hien Nguyen, Thi Bich Hanh Bui, Van Vinh Chau Nguyen, Mary-Louise McLaws
Summary: The study revealed a high prevalence of antibiotic-resistant Gram-negative bacteria intestinal carriage among healthcare workers in Vietnam. Some healthcare workers were identified as persistent and frequent carriers. Therefore, urgent measures are needed to improve the personal hygiene habits of healthcare workers to reduce the transmission of antibiotic-resistant Gram-negative bacteria in hospitals.
INFECTION AND CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Rhonda L. Stuart, Caroline Marshall, Glenys Harrington, Louisa Sasko, Mary-Louise McLaws, John Ferguson
INFECTION DISEASE & HEALTH
(2019)
Article
Law
Catherine Anne Sharp, Jennifer Sarah Schulz Moore, Mary-Louise McLaws
JOURNAL OF LAW AND MEDICINE
(2018)
Review
Health Policy & Services
Tissa Rahim, Pablo Romero Barrios, Geoffrey McKee, Melissa McLaws, Tom Kosatsky
JOURNAL OF COMMUNITY HEALTH
(2018)
Article
Public, Environmental & Occupational Health
Susan Jain, Kate Clezy, Mary-Louise McLaws
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)
Letter
Public, Environmental & Occupational Health
Mary-Louise McLaws, Angela Kwok
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)
Article
Public, Environmental & Occupational Health
Yen Lee Angela Kwok, Peter Harris, Mary-Louise McLaws
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)
Article
Infectious Diseases
Minh Cuong Duong, Mary-Louise McLaws
BMC INFECTIOUS DISEASES
(2017)