Article
Clinical Neurology
Zhangying Wu, Xiaomei Zhong, Gaohong Lin, Qi Peng, Min Zhang, Huarong Zhou, Qiang Wang, Ben Chen, Yuping Ning
Summary: This study found abnormal neural oscillation patterns in patients with late-life depression, characterized by increased power in the alpha and beta frequency bands. These abnormal patterns may be associated with a disturbed balance of cortical excitation, inhibition, and hyperactivity.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Ryan Ahmed, Brian D. Boyd, Damian Elson, Kimberly Albert, Patrick Begnoche, Hakmook Kang, Bennett A. Landman, Sarah M. Szymkowicz, Patricia Andrews, Jennifer Vega, Warren D. Taylor
Summary: This study found that clinical improvement in late-life depression is associated with functional connectivity in intrinsic brain networks, particularly in the default mode, cognitive control, and limbic networks. Future research should focus on clinical markers of network connectivity informing prognosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Weiqi Zhao, Carolina Makowski, Donald J. Hagler, Hugh P. Garavan, Wesley K. Thompson, Deanna J. Greene, Terry L. Jernigan, Anders M. Dale
Summary: By analyzing brain imaging data, it was found that functional connectivity patterns related to behavior can be better predicted using task-based fMRI paradigms, and the changes in brain activity induced by task design are the main driving factor for this prediction advantage.
Article
Clinical Neurology
Carola Dell'Acqua, Shadi Ghiasi, Simone Messerotti Benvenuti, Alberto Greco, Claudio Gentili, Gaetano Valenza
Summary: This study compared EEG results between individuals with dysphoria and healthy controls, finding that while there were no differences in power spectra and asymmetry, dysphoria was associated with dysfunctional brain connectivity in the theta and alpha bands. These connectivity patterns may be related to symptoms of excessive self-focus and rumination typical of depression. EEG connectivity patterns could serve as a promising measure for identifying individuals at higher risk of developing depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Cope Feurer, Jagan Jimmy, Fini Chang, Scott A. Langenecker, K. Luan Phan, Olusola Ajilore, Heide Klumpp
Summary: This study explored the relationship between brain activity and rumination and worry in internalizing conditions. The results indicate the involvement of the affective network in rumination and worry, as well as distinct connectivity patterns observed in patients with internalizing conditions. The findings suggest different mechanisms contribute to rumination as a unitary construct and worry as a unique construct.
DEPRESSION AND ANXIETY
(2021)
Article
Behavioral Sciences
P. M. Briley, L. Webster, C. Boutry, W. J. Cottam, D. P. Auer, P. F. Liddle, R. Morriss
Summary: This systematic review explores the differences in resting-state brain connectivity associated with comorbid anxiety in individuals with MDD. The findings suggest that dysconnectivity between the amygdala and other brain networks, as well as abnormalities in default mode network connectivity, may play a role in the co-occurrence of anxiety and MDD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Clinical
Lizhu Luo, Christelle Langley, Laura Moreno-Lopez, Keith Kendrick, David K. Menon, Emmanuel A. Stamatakis, Barbara J. Sahakian
Summary: This study examined the association between depressive symptoms in traumatic brain injury (TBI) patients and altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. The results showed a positive association between depression scores and rs-fc between limbic regions and cognitive control regions, while there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. These findings contribute to a better understanding of the mechanisms underlying depression following TBI and can inform treatment decisions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Yuqi Cai, Nourhan M. Elsayed, Deanna M. Barch
Summary: Family history of Major Depressive Disorder (MDD) is a strong predictor of MDD onset in early adolescence. Negative wDMN rsFC is associated with current depression in children and current depressive symptoms in parents. Familial risk for depression interacts with wDMN rsFC in association with past MDD diagnosis in children and current depressive symptoms in parents.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Sara M. Motlaghian, Aysenil Belger, Juan R. Bustillo, Judith M. Ford, Armin Iraji, Kelvin Lim, Daniel H. Mathalon, Bryon A. Mueller, Daniel O'Leary, Godfrey Pearlson, Steven G. Potkin, Adrian Preda, Theo G. M. van Erp, Vince D. Calhoun
Summary: In this work, the researchers focused on explicitly nonlinear relationships in functional networks by introducing a technique using normalized mutual information (NMI). They demonstrated their proposed approach using simulated data and applied it to a dataset of schizophrenia patients and healthy controls. The analysis showed a modularized nonlinear relationship among brain functional networks, particularly in the sensory and visual cortex. Group analysis identified significant differences in explicitly nonlinear functional network connectivity (FNC) between the two groups, with controls showing more nonlinearity in most cases. The results suggest that quantifying nonlinear dependencies of functional connectivity may provide a complementary and potentially important tool for studying brain function.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Adnan A. S. Alahmadi
Summary: Spatial smoothing is essential in processing fMRI data to increase signal-to-noise ratio. This study found that spatial smoothing has a greater impact on rsfMRI data when using seed-to-voxel analysis. Results show that a medium smoothing kernel may be preferable for different analyses, and using different smoothing kernels can help confirm the significance of results.
Article
Clinical Neurology
Mingfeng Yang, Ben Chen, Xiaomei Zhong, Huarong Zhou, Naikeng Mai, Min Zhang, Zhangying Wu, Qi Peng, Qiang Wang, Meiling Liu, Si Zhang, Gaohong Lin, Thomas Hummel, Yuping Ning
Summary: This study found that LLD patients with OI impairment exhibited more disrupted olfactory functional connectivity (FC), which may serve as an indicator of dementia risk. The abnormal FCs were associated with OI, global cognition, and language function scores, and the FC between the right piriform cortex and right superior parietal lobule partially mediated the relationship between OI and MMSE scores.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Yu Mao, Qunlin Chen, Dongtao Wei, Wenjing Yang, Jiangzhou Sun, Yaxu Yu, Kaixiang Zhuang, Xiaoqin Wang, Li He, Tingyong Feng, Xu Lei, Qinghua He, Hong Chen, Shukai Duan, Jiang Qiu
Summary: Stressful life events are significant risk factors for depression, and increases in depressive symptoms have been observed during the COVID-19 pandemic. This study used CPM to explore neural markers for depression during COVID-19 and tested their ability to identify high/low risk groups for depression in a longitudinal dataset.
AMERICAN PSYCHOLOGIST
(2022)
Article
Psychiatry
Weicheng Li, Chengyu Wang, Xiaofeng Lan, Ling Fu, Fan Zhang, Yanxiang Ye, Haiyan Liu, Yanling Zhou, Yuping Ning
Summary: This study found distinct patterns of brain functional connectivity between depressive patients with suicidal ideation and without. The suicidal ideation group exhibited different amygdala resting-state functional connectivity patterns, with specific connections associated with cognitive functions.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Xiao-Min Xu, Jian Wang, Richard Salvi, Li-Jie Liu, Yu-Chen Chen, Gao-Jun Teng
Summary: The study aimed to investigate the effects of noise-induced cochlear hearing loss on the central nervous system during the early stage and identify the neural substrate for aberrant patterns mediating noise-related anxiety/depression. Rats were exposed to broad band noise to induce hearing loss. Behavioral tests and resting-state fMRI were conducted to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis revealed widespread reductions in functional connectivity in rats with noise exposure compared to control groups, suggesting an acoustic-causing network for anxiety and depression related to noise exposure.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Pradyumna Lanka, Heather Bortfeld, Theodore J. Huppert
Summary: In resting-state fNIRS data, a processing pipeline incorporating pre-whitening, robust statistical methods, and partial correlation can effectively reduce autocorrelation, motion artifacts, and global physiology, obtaining statistically valid connectivity metrics.