Article
Biochemistry & Molecular Biology
Yaiza Potes, Andrea Diaz-Luis, Juan C. Bermejo-Millo, Zulema Perez-Martinez, Beatriz de Luxan-Delgado, Adrian Rubio-Gonzalez, Ivan Menendez-Valle, Jose Gutierrez-Rodriguez, Juan J. Solano, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes
Summary: Leptin deficiency has multiple effects on skeletal muscle, including stimulation of fatty acid oxidation, suppression of mitochondrial oxidative damage, and increased cytosolic oxidative damage. Melatonin treatment plays a significant role in reducing cellular oxidative damage, regulating energy homeostasis, and improving mitochondrial metabolism.
Article
Medicine, Research & Experimental
Fabiane Ferreira Martins, Thiago Santos-Reis, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: The aim of this study was to examine the effects of semaglutide on neuropeptide signaling in the hypothalamic energy metabolism of diet-induced obese mice. The results showed that semaglutide improved leptin sensitivity and anorexigenic signaling, while decreasing orexigenic signaling. Furthermore, semaglutide also affected biometric data and hypothalamic gene expressions. Therefore, semaglutide can activate anorexigenic signaling by restoring leptin, amylin, and POMC pathways in diet-induced obese mice.
Review
Endocrinology & Metabolism
Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J. Stewart, Takashi Gojobori, Esma R. Isenovic
Summary: Leptin, a peptide hormone, regulates food intake, body mass, and reproductive function, playing a crucial role in fetal growth, immune responses, angiogenesis, and lipolysis. Leptin resistance can lead to reduced satiety, overconsumption of nutrients, and increased body mass, potentially causing obesity. Combining leptin therapies with sensitizers may help overcome resistance and treat obesity effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Nikolai P. Jaschke, Sophie Paehlig, Tilman D. Rachner
Summary: Soluble mediators secreted by skeletal muscles, known as myokines, signal to distant organs and play a role in protecting the central nervous system against pathological protein accumulation in response to stress. Rai et al. have uncovered a muscle-to-central nervous system signaling axis that is engaged during proteostatic stress.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Analytical
Ryong Sung, Yun Seok Heo
Summary: Leptin, a peptide hormone produced in adipose tissues, is considered a biomarker for obesity-related diseases. An electrochemical biosensor was introduced in this study to detect leptin in mouse blood, showing high stability, sensitivity, and selectivity. The biosensor could potentially serve as a sensitive analytical tool for detecting biomarkers in clinical settings and point-of-care testing.
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Review
Endocrinology & Metabolism
Kenny Mendoza-Herrera, Andrea A. Florio, Maggie Moore, Abrania Marrero, Martha Tamez, Shilpa N. Bhupathiraju, Josiemer Mattei
Summary: This review focuses on the relationship between diet and leptin, suggesting that addressing leptin resistance through dietary interventions can counteract obesity. High-fat, high-carbohydrate, fructose, and sucrose diets, low in protein, contribute to leptin resistance, while energy-restricted diets can reduce leptin levels and potentially reverse resistance. Further research on reliable methods to measure resistance and alternative approaches like leptin sensitizers and genetically individualized diets is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud A. Alfaqih, Lina Elsalem, Mohamad Nusier, Khawla Mhedat, Yousef Khader, Ebaa Ababneh
Summary: This study found a correlation between obesity and increased risk of bladder cancer. The levels of leptin and its receptor are often deregulated in obese individuals and these changes are associated with the development of bladder cancer. Additionally, certain genetic variants are also associated with bladder cancer.
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juan Antonio Flores-Cordero, Antonio Perez-Perez, Carlos Jimenez-Cortegana, Gonzalo Alba, Alfonso Flores-Barragan, Victor Sanchez-Margalet
Summary: Obesity is a global health problem and leptin resistance, a mechanism of obesity, is associated with the development of Alzheimer's Disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Xin Su, Ye Cheng, Dong Chang
Summary: Obesity is associated with dysfunctional adipocytes that produce excessive pro-inflammatory adipokines, while leptin plays a vital role in regulating angiogenesis, lipid metabolism, and cytokine production. Increased leptin levels and impaired signaling pathway can impact various skin diseases, highlighting the complex relationship between leptin and dermatological disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Yong Han, Yang He, Lauren Harris, Yong Xu, Qi Wu
Summary: This study demonstrates the role of GABAergic neural circuit in regulating food intake and energy balance through the leptin-responsive neural circuit, providing a new avenue for therapeutic interventions in the treatment of obesity and associated comorbidities.
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Lourdes Hontecillas-Prieto, Daniel J. Garcia-Dominguez, Fernando Zapata, Natalia Palazon-Carrion, Maria L. Sanchez-Leon, Malika Tami, Antonio Perez-Perez, Flora Sanchez-Jimenez, Teresa Vilarino-Garcia, Luis De la Cruz-Merino, Victor Sanchez-Margalet
Summary: Obesity is considered a pandemic and a risk factor for various types of cancers, including lymphoma, due to its promotion of an inflammatory state. Leptin, as a key adipokine, has been studied for its potential role in connecting obesity and lymphomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Stephanie Brandt, Julia von Schnurbein, Christian Denzer, Wolfgang Kratzer, Martin Wabitsch
Summary: Circulating leptin levels in pre-pubertal children with obesity are negatively associated with steatosis hepatis, and children with low leptin levels have higher triglyceride, fasting insulin, and c-peptide levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youchao Xiao, Wentao Wu, Kefan Cai, Lu Jin, Yanfei Jia, Ning Qiao, Fangzheng Liu, Siming Ru, Lei Cao, Songbai Gui
Summary: Craniopharyngioma (CP) is a benign tumor associated with obesity and recurrence. The role of leptin/leptin receptors axis in CP and its association with weight-related outcomes and prognosis were studied. High plasma leptin level and leptin receptor overexpression were found in CP patients, which were independent risk factors for weight gain and poor progression-free survival (PFS). Leptin/leptin receptors axis may be a potential therapeutic target for obesity in CP patients.