Article
Biology
Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Severi, Paola Rizzo, Iija Gardi, Paolo Cimaglia, Claudio Rapezzi, Luigi Tavazzi, Roberto Ferrari
Summary: This review discusses the pathogenesis and therapeutic approaches of vascular and heart calcifications in different conditions. Calcifications are complex disorders that have significant implications for cardiovascular and kidney diseases.
Article
Medicine, Research & Experimental
Yaxin Lian, Yue Li, Aiting Liu, Sounak Ghosh, Yuncong Shi, Hui Huang
Summary: This article provides an overview of the key role of oxidative stress in vascular calcification (VC) and discusses the challenges surrounding the use of dietary antioxidants in preventing VC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Haitao Zhang, Guisen Li, Xueqing Yu, Junwei Yang, Aili Jiang, Hong Cheng, Junzhou Fu, Xinling Liang, Jun Liu, Jizhuang Lou, Mei Wang, Changying Xing, Aihua Zhang, Miao Zhang, Xiangcheng Xiao, Chen Yu, Rong Wang, Li Wang, Yuqing Chen, Tianjun Guan, Ai Peng, Nan Chen, Chuanming Hao, Bicheng Liu, Suxia Wang, Dan Shen, Zhenhua Jia, Zhihong Liu
Summary: Baseline findings from the China Dialysis Calcification Study revealed a high prevalence of vascular calcification among patients with end-stage kidney disease, but data on calcification progression were limited. This study aimed to understand the progression of calcification at different anatomical sites, identify risk factors, and assess the association with cardiovascular events and death. The results may have implications for improving the management of chronic kidney disease-mineral and bone disorder among dialysis patients.
Review
Genetics & Heredity
Philip Duesing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen
Summary: CKD and CVD are interlinked, with CKD increasing the risk of cardiovascular disease mainly due to accumulation of uremic toxins, chronic inflammation, and oxidative stress. Vascular alterations, especially atherosclerosis and vascular calcification, play a significant role in the association between CKD and cardiovascular mortality.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Nannan Ding, Yaodong Lv, Hong Su, Ziyang Wang, Xianglei Kong, Junhui Zhen, Zhimei Lv, Rong Wang
Summary: Vascular calcification is a common complication of chronic kidney disease and poses an increased risk of cardiovascular morbidity and mortality. The process of calcification in CKD is actively regulated and cell-mediated, involving factors such as hyperphosphatemia, uremic toxins, oxidative stress, inflammation, and epigenetic modifications. Despite advancements in understanding the factors and mechanisms involved, many questions remain unanswered. Further research on the role of epigenetic modifications in uremic vascular calcification may lead to promising therapies for CKD-related cardiovascular events in the future.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nima Abbasian
Summary: Vascular calcification (VC) is often seen in patients with chronic kidney disease (CKD) and is related to high serum phosphate levels. The pathologies associated with high phosphate can lead to VC development.
Article
Biochemistry & Molecular Biology
Tamas Gall, Peter Nagy, Dorottya Garai, Laszlo Potor, Gyorgy Jazon Balla, Gyorgy Balla, Jozsef Balla
Summary: Vulnerable atherosclerotic plaques with hemorrhage significantly contribute to cardiovascular morbidity and mortality, and calcification is their main characteristic. Hydrogen sulfide may play beneficial effects in the progression of atherosclerosis and can suppress the oxidation of Hb/heme.
Review
Medicine, Research & Experimental
Raul Fernandez-Prado, Priscila Villalvazo, Alejandro Avello, Marina Gonzalez-de-Rivera, Michelle Aguirre, Carlos G. Carrasco-Munoz, Beatriz Fernandez-Fernandez, Catalina Martin-Cleary, Sol Carriazo, Maria Dolores Sanchez-Nino, Maria Vanessa Perez-Gomez, Alberto Ortiz
Summary: Metabolic acidosis is common in CKD and has various negative effects. SZC, a potassium binder, has been shown to increase serum bicarbonate and decrease serum urea, potentially providing benefits in CKD management. The mechanism of action appears to involve SZC binding to ammonium ions in the gut, preventing their absorption and promoting the excretion of H+ ions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ainun Nizar Masbuchin, Mohammad Saifur Rohman, Ping-Yen Liu
Summary: Recent evidence has highlighted the importance of glycosylation in vascular calcification, involving N-glycosylation, O-glycosylation, and glycosylation mechanisms that lead to the formation of proteoglycans. This information reveals a close relationship between glycosylation and vascular calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Iain Bressendorff, Ditte Hansen, Morten Schou, Charlotte Kragelund, My Svensson, Bahram Hashemi, Tilde Kristensen, Marie Houmaa Vrist, Rikke Borg, Birgitte Tougaard, Kristine Borg, Henrik Oder Hjortkjaer, Cathrine Helgestad Kristiansen, Nicholas Carlson, Mohammad Nasiri, Haseem Ashraf, Andreas Pasch, Lisbet Brandi
Summary: This study aimed to investigate whether oral magnesium supplementation could slow the progression of vascular calcification in patients with CKD. However, the results showed that magnesium supplementation did not slow the progression of vascular calcification in CKD, despite an increase in plasma magnesium level.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
D. Matthew Worssam, F. Helle Jorgensen
Summary: Vascular smooth muscle cells play major roles in pathological vascular remodelling, with clonal lineage tracing revealing that their contribution to disease results from hyperproliferation of a few pre-existing medial cells that can adopt diverse phenotypes. Studies have shown that VSMC-derived cells in vascular lesions have both beneficial and detrimental effects on disease severity. Computational analyses suggest that the pathway from healthy arteries to phenotypically distinct lesional cells consists of multiple, potentially regulatable, steps.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Review
Medicine, General & Internal
Jordi Bover, Armando Aguilar, Carolt Arana, Pablo Molina, Maria Jesus Lloret, Jackson Ochoa, Gerson Berna, Yessica G. Gutierrez-Maza, Natacha Rodrigues, Luis D'Marco, Jose L. Gorriz
Summary: Chronic kidney disease (CKD) poses a high cardiovascular risk, often leading to CKD-mineral and bone disorders (CKD-MBDs) and subsequent vascular calcifications, which are prevalent and aggressive in CKD patients. Vascular calcification (VC) is a significant concern in CKD management, with potential implications for therapeutic interventions and patient risk stratification.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Antonio Bellasi, Luca Di Lullo, Domenico Russo, Roberto Ciarcia, Michele Magnocavallo, Carlo Lavalle, Carlo Ratti, Maria Fusaro, Mario Cozzolino, Biagio Raffaele Di Iorio
Summary: In patients starting hemodialysis, the presence and extension of vascular calcification (VC) can predict the risk of all-cause death, regardless of the arterial site, and provide better risk assessment capabilities than traditional cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ricardo Villa-Bellosta
Summary: Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are the leading cause of morbimortality in Western society, often associated with vascular calcification. The balance between phosphate and pyrophosphate, strictly controlled by several genes, plays a key role in calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Upasana Maheshwari, Sheng-Fu Huang, Sucheta Sridhar, Annika Keller
Summary: Vascular calcifications refer to the ectopic deposition of calcium and phosphate in the blood vessels, often associated with pathological conditions. While peripheral organ vascular calcifications have been extensively studied, the understanding of vascular calcification in the central nervous system is limited. This review focuses on the occurrence of vessel calcifications in the brain in relation to aging and various brain diseases, using primary familial brain calcification as an example. The role of microglia in the brain's response to vessel calcification and their involvement in the clearance of calcifications are discussed.
FRONTIERS IN AGING NEUROSCIENCE
(2022)