Review
Cell Biology
Wolfgang Loescher, H. Steve White
Summary: In the past 30 years, many new anti-seizure medicines have been developed for epilepsy treatment, but drug-resistant epilepsy (DRE) still affects a significant percentage of patients. Current approaches to discovering new DRE treatments involve testing drugs in preclinical models that show varying degrees of drug resistance. Recent efforts have been made to include more relevant models in the evaluation of investigational drugs, to better understand DRE mechanisms and test new therapies. This review discusses the pharmacology of different epilepsy models and the challenges in identifying novel treatments.
Article
Neurosciences
Alexandre Vigier, Nicolas Partouche, Francois J. Michel, Valerie Crepel, Thomas Marissal
Summary: Researchers have developed an improved protocol that increases the survival rate of the pilocarpine mouse model of temporal lobe epilepsy by injecting a moderate dose of caffeine during the induction phase. This new protocol also involves using young male mice and a refined scoring system.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biology
P. Kleis, E. Paschen, U. Haussler, Y. A. Bernal Sierra, C. A. Haas
Summary: This study highlights the PACK tool as a potent optogenetic inhibitor in vivo, but further refinement of its light-sensitive domain is required to avoid unexpected physiological changes.
Review
Biochemistry & Molecular Biology
Jose Vicente Negrete-Diaz, Rafael Falcon-Moya, Antonio Rodriguez-Moreno
Summary: Kainate receptors are involved in controlling neuronal excitability, modulating the release of neurotransmitters like GABA and glutamate, and regulating long- and short-term plasticity. Altered activity of these receptors is associated with various central nervous system diseases and disturbances.
Article
Neurosciences
F. A. Concepcion, N. A. Ekstrom, M. N. Khan O. O. Estes, N. P. Poolos
Summary: This study investigated the expression and phosphorylation of the intracellular protein Tau in a rat model of temporal lobe epilepsy. The results showed that although Tau expression levels had a modest reduction at two months post-seizure, they had returned to normal by four months. However, there was a significant decrease in phosphorylation levels at the S202/T205 locus. These findings suggest that Tau may play a different role in epilepsy compared to Alzheimer's disease.
Article
Endocrinology & Metabolism
Pablo Bascunana, Bettina J. Wolf, Ina Jahreis, Mirjam Brackhan, Luis Garcia-Garcia, Tobias L. Ross, Frank M. Bengel, Marion Bankstahl, Jens P. Bankstahl
Summary: During and after status epilepticus (SE), rat brain perfusion shows significant spatiotemporal changes with increased cortical perfusion initially, regional hypo-perfusion during the first convulsive seizure, and markedly decreased uptake 24 hours post-SE. Chronic epileptic animals exhibit regionally decreased perfusion affecting hippocampus and cortical sub-regions. Despite elevated energy and oxygen requirements, brain hypo-perfusion is present during SE, potentially contributing to neuronal damage, neuroinflammation, and chronic epilepsy following SE.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Xiao-Shan Liang, Ting-Lin Qian, Yi-Fan Xiong, Xiao-Tao Liang, Yue-Wen Ding, Xiao-Yu Zhu, Yun-Lv Li, Jie-Li Zhou, Le-Yi Tan, Wei-Peng Li, Wei Xie
Summary: This study used an epilepsy mouse model and found that IRAK-M knockout exacerbated seizures and pathology, increased glutamatergic synaptic transmission, and induced microglial M1 polarization and inflammation. These findings suggest that IRAK-M dysfunction contributes to the progression of epilepsy through NMDARs.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sarah S. El-Sayed, Mohammed F. El-Yamany, Hesham A. Salem, Ayman E. El-Sahar
Summary: The study investigated the modulatory effects of Vinpocetine (VNP) on neurobehavioral comorbidities via the mTOR signaling pathway in a lithium-pilocarpine (Li-Pil) rat model of seizures. VNP demonstrated a protective effect against Li-Pil-induced seizures and improved locomotor and cognitive abilities, while also exerting a neuroprotective action through inhibitory effects on hippocampal glutamate excitotoxicity, mTOR pathway, and inflammatory and apoptotic parameters.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mariana Uczay, Pricila Pfluger, Jaqueline Nascimento Picada, Joao Denis Medeiros de Oliveira, Iraci Lucena da SilvaTorres, Helouise Richardt Medeiros, Maria Helena Vendruscolo, Gilsane von Poser, Patricia Pereira
Summary: This study investigated the mechanism of action of Asperuloside (ASP) and geniposide (GP) in pilocarpine-induced seizures. The results showed that GP and ASP could reduce the latency to the first seizure, as well as the expression of GluN2B receptor and COX-2.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kai Zhong, Chengyu Qian, Rui Lyu, Xinyi Wang, Zhe Hu, Jie Yu, Jing Ma, Yilu Ye
Summary: Crocin has shown anti-epileptic effects in models of temporal lobe epilepsy, reducing seizure stages and duration, as well as suppressing generalized and spontaneous recurrent seizures. These effects may be mediated by its neuroprotective properties and modulation of inflammatory and neurotrophic factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iran M. Cumbres-Vargas, Sergio R. Zamudio, Luz A. Pichardo-Macias, Eduardo Ramirez-San Juan
Summary: Thalidomide has potential therapeutic effects in neurological diseases such as epilepsy and may act as an antiepileptic drug and treatment against disease development. This study evaluated the antiepileptogenic and anti-inflammatory effects of Thalidomide, showing promising results in terms of reducing seizure frequency and neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Thiago S. Charret, Mariana T. M. Pereira, Vinicius D. B. Pascoal, Iscia Lopes-Cendes, Aislan Cristina Rheder Fagundes Pascoal
Summary: Research has shown that citral has inhibitory effects on status epilepticus in a rat model, increasing latency for seizure development, reducing neuronal death, and inhibiting overexpression of proinflammatory genes.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Biochemistry & Molecular Biology
Adrienne Matyas, Emoke Borbely, Andras Mihaly
Summary: The present experiments reveal the alterations of hippocampal neuronal populations in chronic epilepsy. The mice exhibited impaired learning and memory functions, decreased neuronal count, activated microglia, increased expression of certain neuropeptides, and reduced number of inhibitory neurons in the hippocampus. These findings shed light on the mechanisms underlying the hippocampal learning and memory deficits in epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuxiang Li, Fangchao Tong, Lu Liu, Zhongqian Su, Jing Ding, Qiang Wang, Xin Wang
Summary: Mossy fiber sprouting is a characteristic of epilepsy and plays a key role in neural circuit formation. CRMP2, whose phosphorylation state regulates neurite/axon outgrowth, has been reported to change in epilepsy patients and animal models. This study provides direct evidence supporting the role of CRMP2 in mossy fiber sprouting in an animal model of epilepsy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
Christophe Mulle, Valerie Crepel
Summary: Kainate receptors (KARs) are ionotropic glutamate receptors that play important physiological roles in neuronal circuits, regulating EPSCs as post-synaptic receptors and controlling ion channels through non-canonical metabotropic actions. KARs, activated by endogenous glutamate, modulate neuronal circuit activity and plasticity under normal physiological conditions.
Article
Clinical Neurology
Woo-Jin Lee, Young Nam Kwon, Boram Kim, Jangsup Moon, Kyung-Il Park, Kon Chu, Jung-Joon Sung, Sang Kun Lee, Sung-Min Kim, Soon-Tae Lee
Summary: This study investigated the clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein (MOG) antibody-associated autoimmune encephalitis (MOGAE) in adult patients. The results showed that the outcomes varied according to the three phenotypes in MOGAE. Short immunotherapy maintenance was associated with relapse, and brain atrophy and dual antibodies of NMDAR and MOG were associated with poor outcomes.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Seondeuk Kim, Jangsup Moon, Keun-Hwa Jung, Seon-Jae Anh, Han Sang Lee, Yoonhyuk Jang, Kyung-Il Park, Sang Kun Lee, Kon Chu
Summary: This study retrospectively analyzed the genetic tests of clinical FCCM patients and found that brainstem lesions could be a radiologic marker for FCCM with the mutation detected. The age-related disease burden regarding FCCM was also demonstrated according to genetic information.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Article
Computer Science, Interdisciplinary Applications
Hyun Kim, Pukyeong Seo, Min Ju Kim, Jun Il Huh, Jun-Sang Sunwoo, Kwang Su Cha, El Jeong, Han -Joon Kim, Ki-Young Jung, Kyung Hwan Kim
Summary: This study investigated the spatiotemporal characteristics of cortical activities underlying impaired visuospatial attention in idiopathic rapid eye movement sleep behavior disorder (iRBD) patients using an explainable machine-learning approach. A convolutional neural network (CNN) algorithm was employed to discriminate cortical current source activities of iRBD patients from normal controls based on single-trial event-related potentials (ERPs). The findings revealed the relevant cortical regions and neural activity impairment associated with cognitive impairment in iRBD, which may contribute to the development of biomarkers for iRBD based on neural activity.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Tae Jung Kim, Ji Sung Lee, Jae Sun Yoon, Mi Sun Oh, Ji-Woo Kim, Soo-Hyun Park, Keun-Hwa Jung, Hyun Young Kim, Jee-Hyun Kwon, Hye-Yeon Choi, Hahn Young Kim, Kyung Yoon Eah, Sang Won Han, Hyung-Geun Oh, Young-Jae Kim, Byoung-Soo Shin, Chang Hun Kim, Chi Kyung Kim, Jong-Moo Park, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Man-Seok Park, Jay Chol Choi, Chulho Kim, Dong-Ick Shin, Soo Joo Lee, Dong-Eog Kim, Jae-Kwan Cha, Eung-Gyu Kim, Kyung-Ho Yu, Keun-Sik Hong, Young-Seok Lee, Ju-Hun Lee, Sung Il Sohn, Hee-Joon Bae, Young-Bae Lee, Jun Hong Lee, Joung-Ho Rha, Byung-Chul Lee, Dae-Il Chang, Sang-Bae Ko, Byung-Woo Yoon
Summary: This study found that monotherapy with oral anticoagulants was associated with a lower risk of composite outcomes and death at 1 year after ischemic stroke due to atrial fibrillation and atherosclerotic stenosis. However, the combination of antiplatelet agents and oral anticoagulants had a higher risk of major bleeding.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Clinical Neurology
Jiyeon Ha, Seondeuk Kim, Han-Sang Lee, Keun-Hwa Jung
Article
Clinical Neurology
Kyung-Il Park, Sungeun Hwang, Hyoshin Son, Kon Chu, Ki-Young Jung, Sang Kun Lee
Summary: This study aimed to identify factors related to PER retention and polytherapy pattern. Among 2,655 patients with epilepsy, 328 patients were enrolled. The retention of PER was associated with younger age at onset, indicating longer usage in patients with a lower age at onset.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Hyoshin Son, Kyung-Il Park, Dae-Seop Shin, Jangsup Moon, Soon -Tae Lee, Keun-Hwa Jung, Ki-Young Jung, Kon Chu, Sang Kun Lee
Summary: This study aimed to evaluate the supportive value of the morphometric analysis program (MAP) in detecting focal cortical dysplasia (FCD) in a single institution in Korea. The MAP, combined with interpretations by radiologists, was found to increase the detection rate of FCD. The MAP showed the strongest ability in detecting FCD IIa and was not affected by the type of reference scanner.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Letter
Clinical Neurology
Seondeuk Kim, Seoyeon Kim, Yoonhyuk Jang, Kon Chu
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Soo Hwan Yim, Jun-Sang Sunwoo, Daeyoung Kim, Min Kyung Chu, Chang-Ho Yun, Kwang Ik Yang
Summary: This study investigated the relationship between fatigue, excessive daytime sleepiness, and depression, finding that both fatigue and excessive daytime sleepiness were associated with depression regardless of the presence of each other.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Yoonhyuk Jang, Kwanghoon Lee, Cheol Lee, Kon Chu, Sang Kun Lee, Jae-Kyung Won, Soon-Tae Lee
Summary: By comparing NMDARe-associated teratomas with non-encephalitic control teratomas, it was found that there were no significant differences in mutations between the two types of teratomas in terms of genomic analysis. Pathologic analysis revealed similar presence of neuronal tissue and lymphocytic infiltration between the two groups, but rituximab-naive encephalitic teratomas showed a higher frequency of germinal center formation.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyung-Il Park, Keun-Hwa Jung, Eung-Joon Lee, Woo-Jin Lee, Seol Ah Hwang, Sohyun Kim, David H. Salat
Summary: The burden of cerebral small vessel disease (SVD) was categorized into three classes based on the integration of white matter signal abnormalities (WMSA) features and the presence of lacunes, microbleeds, and enlarged perivascular spaces. This categorization improved the understanding of SVD pathophysiology, risk stratification, and outcome prediction.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
