Methylated nucleosides in tRNA and tRNA methyltransferases

Activation of a Unique Flavin-Dependent tRNA-Methylating Agent

(2013) Djemel Hamdane et al.   BIOCHEMISTRY

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Radical SAM-mediated methylation reactions

(2013) Danica Galonić Fujimori   CURRENT OPINION IN CHEMICAL BIOLOGY

Distinct tRNA modifications in the thermo-acidophilic archaeon,Thermoplasma acidophilum

(2013) Chie Tomikawa et al.   FEBS LETTERS

Decoding Mechanism of Non-universal Genetic Codes inLoligo bleekeriMitochondria

(2013) Takayuki Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Catalytic Domain of Topological Knot tRNA Methyltransferase (TrmH) Discriminates between Substrate tRNA and Nonsubstrate tRNA via an Induced-fit Process

(2013) Anna Ochi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

(2013) Zhenhua Shao et al.   NUCLEIC ACIDS RESEARCH

The output of the tRNA modification pathways controlled by the Escherichia coli MnmEG and MnmC enzymes depends on the growth conditions and the tRNA species

(2013) Ismaïl Moukadiri et al.   NUCLEIC ACIDS RESEARCH

The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL

(2013) Ru-Juan Liu et al.   NUCLEIC ACIDS RESEARCH

Conservation of structure and mechanism by Trm5 enzymes

(2013) T. Christian et al.   RNA

The T. brucei TRM5 methyltransferase plays an essential role in mitochondrial protein synthesis and function

(2013) Z. Paris et al.   RNA

Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10

(2013) W. E. Swinehart et al.   RNA

Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC

(2013) Jungwook Kim et al.   BMC STRUCTURAL BIOLOGY

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs

(2013) Sarit Edelheit et al.   PLoS Genetics

Enzymology of tRNA modification in the bacterial MnmEG pathway

(2012) M.-Eugenia Armengod et al.   BIOCHIMIE

A Role for tRNA Modifications in Genome Structure and Codon Usage

(2012) Eva Maria Novoa et al.   CELL

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

(2012) Ashish Patil et al.   CELL CYCLE

The tRNA Recognition Mechanism of Folate/FAD-dependent tRNA Methyltransferase (TrmFO)

(2012) Ryota Yamagami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Demethylwyosine Synthase fromPyrococcus abyssiIs a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2Cluster That Interacts with the Pyruvate Co-substrate

(2012) Phanélie Perche-Letuvée et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and Structure of theAquifex aeolicusProtein DUF752

(2012) Aya Kitamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

(2012) Stefanie Jöckel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

(2012) Stefanie Gehrig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FAD/Folate-Dependent tRNA Methyltransferase: Flavin as a New Methyl-Transfer Agent

(2012) Djemel Hamdane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification

(2012) Kenjyo Miyauchi et al.   Nature Chemical Biology

Crystal structures of the tRNA:m 2 G6 methyltransferase Trm14/TrmN from two domains of life

(2012) Marcus Fislage et al.   NUCLEIC ACIDS RESEARCH

In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya

(2012) Ludovic Perrochia et al.   NUCLEIC ACIDS RESEARCH

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis

(2012) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

The human tRNA m5C methyltransferase Misu is multisite-specific

(2012) Sylvie Auxilien et al.   RNA Biology

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications

(2012) Ashish Patil et al.   RNA Biology

tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae

(2012) M. A. Preston et al.   RNA

The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N2-methylguanosine at position 6 in tRNA

(2012) M. Roovers et al.   RNA

Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs

(2012) J. P. Wurm et al.   RNA

Recognition of guanosine by dissimilar tRNA methyltransferases

(2012) R. Sakaguchi et al.   RNA

The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA

(2012) K. Chatterjee et al.   RNA

Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop

(2012) M. P. Guy et al.   RNA

The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications

(2012) J. M. Dewe et al.   RNA

Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs

(2012) T. Chujo et al.   RNA

Aspects of HIV-1 assembly that promote primer tRNALys3 annealing to viral RNA

(2012) Jenan Saadatmand et al.   VIRUS RESEARCH

Initiation of HIV-1 reverse transcription and functional role of nucleocapsid-mediated tRNA/viral genome interactions

(2012) Dona Sleiman et al.   VIRUS RESEARCH

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Diversity of Archaeosine Synthesis in Crenarchaeota

(2011) Gabriela Phillips et al.   ACS Chemical Biology

Crystallization and preliminary X-ray diffraction crystallographic study of tRNA m1A58 methyltransferase fromSaccharomyces cerevisiae

(2011) Xiaoting Qiu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A Catalytic Intermediate and Several Flavin Redox States Stabilized by Folate-Dependent tRNA Methyltransferase fromBacillus subtilis

(2011) Djemel Hamdane et al.   BIOCHEMISTRY

The methylthiolation reaction mediated by the Radical-SAM enzymes

(2011) Mohamed Atta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transfer RNA Methytransferases and Their Corresponding Modifications in Budding Yeast and Humans: Activities, Predications, and Potential Roles in Human Health

(2011) William L. Towns et al.   DNA AND CELL BIOLOGY

Taurine-containing Uridine Modifications in tRNA Anticodons Are Required to Decipher Non-universal Genetic Codes in Ascidian Mitochondria

(2011) Takeo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate tRNA Recognition Mechanism of a Multisite-specific tRNA Methyltransferase,Aquifex aeolicusTrm1, Based on the X-ray Crystal Structure

(2011) Takako Awai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Folate/FAD-dependent tRNA Methyltransferase Mechanism

(2011) Djemel Hamdane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification

(2011) Chiara Pastore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice

(2011) Fan-Yan Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis for site-specific ribose methylation by box C/D RNA protein complexes

(2011) Jinzhong Lin et al.   NATURE

Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U

(2011) David Pearson et al.   NUCLEIC ACIDS RESEARCH

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA

(2011) Vibeke Leihne et al.   NUCLEIC ACIDS RESEARCH

Formation of m 2 G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14

(2011) Sheena Menezes et al.   NUCLEIC ACIDS RESEARCH

Mechanism of activation of methyltransferases involved in translation by the Trm112 ‘hub’ protein

(2011) Dominique Liger et al.   NUCLEIC ACIDS RESEARCH

Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U

(2011) Changchun Chen et al.   PLoS One

Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast

(2011) T. Ohira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli

(2011) Aya Kitamura et al.   PROTEIN SCIENCE

2'-O-methylation of the wobble residue of elongator pre-tRNAMetinHaloferax volcaniiis guided by a box C/D RNA containing unique features

(2011) Archi Joardar et al.   RNA Biology

Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae

(2011) A. Noma et al.   RNA

A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop

(2011) S. D'Silva et al.   RNA

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

Structural comparison of tRNA m1A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions

(2011) Amandine Guelorget et al.   BMC STRUCTURAL BIOLOGY

Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs

(2011) Suzuki Tsutomu et al.   Wiley Interdisciplinary Reviews-RNA

tRNA Stabilization by Modified Nucleotides

(2010) Yuri Motorin et al.   BIOCHEMISTRY

S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

(2010) Mohamed Atta et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

Flexible Recognition of the tRNA G18 Methylation Target Site by TrmH Methyltransferase through First Binding and Induced Fit Processes

(2010) Anna Ochi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA

(2010) Simon Arragain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of G Domain Conformations in the tRNA-modifying MnmE-GidA Complex Observed with Double Electron Electron Resonance Spectroscopy

(2010) Sabine Böhme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trm112p Is a 15-kDa Zinc Finger Protein Essential for the Activity of Two tRNA and One Protein Methyltransferases in Yeast

(2010) Marie-Hélène Mazauric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanding Role of the Jumonji C Domain as an RNA Hydroxylase

(2010) Akiko Noma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Methanocaldococcus jannaschii Trm4 Complexed with Sinefungin

(2010) Mitsuo Kuratani et al.   JOURNAL OF MOLECULAR BIOLOGY

Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding

(2010) L. Songe-Moller et al.   MOLECULAR AND CELLULAR BIOLOGY

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Biosynthesis of Wyosine Derivatives in tRNA: An Ancient and Highly Diverse Pathway in Archaea

(2010) Valérie de Crécy-Lagard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea

(2010) Yoshiho Ikeuchi et al.   Nature Chemical Biology

Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus

(2010) Kazuo Ishida et al.   NUCLEIC ACIDS RESEARCH

New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA

(2010) M. Kempenaers et al.   NUCLEIC ACIDS RESEARCH

Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase

(2010) Amandine Guelorget et al.   NUCLEIC ACIDS RESEARCH

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases

(2010) S. Auxilien et al.   RNA

YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNALeu isoacceptors

(2010) A. Benitez-Paez et al.   RNA

Crystal Structure of Mj1640/DUF358 Protein Reveals a Putative SPOUT-Class RNA Methyltransferase

(2010) H.-Y. Chen et al.   Journal of Molecular Cell Biology

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

Discovery and characterization of tRNAIle lysidine synthetase (TilS)

(2009) Tsutomu Suzuki et al.   FEBS LETTERS

Stereochemical mechanisms of tRNA methyltransferases

(2009) Ya-Ming Hou et al.   FEBS LETTERS

Structure-Function Analysis of Escherichia coli MnmG (GidA), a Highly Conserved tRNA-Modifying Enzyme

(2009) R. Shi et al.   JOURNAL OF BACTERIOLOGY

Aquifex aeolicustRNA (N2,N2-Guanine)-dimethyltransferase (Trm1) Catalyzes Transfer of Methyl Groups Not Only to Guanine 26 but Also to Guanine 27 in tRNA

(2009) Takako Awai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-Domain Dimerization Orchestrates the tRNA Wobble Modification Reaction in the MnmE/GidA Complex

(2009) Simon Meyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Trm13p, the tRNA:Xm4 modification enzyme from Saccharomyces cerevisiae is a member of the Rossmann-fold MTase superfamily: prediction of structure and active site

(2009) Karolina L. Tkaczuk   JOURNAL OF MOLECULAR MODELING

Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation

(2009) Sakurako Goto-Ito et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N 7-Methylguanine at position 46 (m7G46) in tRNA from Thermus thermophilus is required for cell viability at high temperatures through a tRNA modification network

(2009) Chie Tomikawa et al.   NUCLEIC ACIDS RESEARCH

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

(2009) Ismaïl Moukadiri et al.   NUCLEIC ACIDS RESEARCH

Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2

(2009) M. Umitsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase

(2009) H. Nishimasu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural organization of box C/D RNA-guided RNA methyltransferase

(2009) K. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved Cysteine Residues of GidA Are Essential for Biogenesis of 5-Carboxymethylaminomethyluridine at tRNA Anticodon

(2009) Takuo Osawa et al.   STRUCTURE

Mechanism and a Peptide Motif for Targeting Peripheral Proteins to the Yeast Inner Nuclear Membrane

(2009) Tsung-Po Lai et al.   TRAFFIC

RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes

(2008) Henri Grosjean et al.   BMC GENOMICS

Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors

(2008) Naoki Shigi et al.   EMBO JOURNAL

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon

(2008) Yoshiho Ikeuchi et al.   EMBO JOURNAL

Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1

(2008) I. Chernyakov et al.   GENES & DEVELOPMENT

Stabilization of tRNA (m1G37) methyltransferase [TrmD] fromAquifex aeolicusby an intersubunit disulfide bond formation

(2008) Takashi Toyooka et al.   GENES TO CELLS

Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding

(2008) Shinya Kurata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of tRNA N2,N2-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii

(2008) Ihsanawati et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of the Conserved tRNA-Modifying Enzyme GidA: Implications for Its Interaction with MnmE and Substrate

(2008) S. Meyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Thermus thermophilus tRNA m1A58 Methyltransferase and Biophysical Characterization of Its Interaction with tRNA

(2008) Pierre Barraud et al.   JOURNAL OF MOLECULAR BIOLOGY

The primary target of the killer toxin fromPichia acaciaeis tRNAGln

(2008) Roland Klassen et al.   MOLECULAR MICROBIOLOGY

The YqfN protein of Bacillus subtilis is the tRNA: m 1 A22 methyltransferase (TrmK)

(2008) Martine Roovers et al.   NUCLEIC ACIDS RESEARCH

Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases

(2008) A. Alian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA

(2008) Martine Roovers et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal structure of archaeal tRNA(m1G37)methyltransferase aTrm5

(2008) Sakurako Goto-Ito et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of the Yeast tRNA m7G Methylation Complex

(2008) Nicolas Leulliot et al.   STRUCTURE

Crystal Structure and Mutational Study of a Unique SpoU Family Archaeal Methylase that Forms 2′-O-Methylcytidine at Position 56 of tRNA

(2007) Mitsuo Kuratani et al.   JOURNAL OF MOLECULAR BIOLOGY