Article
Cell Biology
Lulu Su, Yinping Dong, Yueying Wang, Yuquan Wang, Bowen Guan, Yanhua Lu, Jing Wu, Xiaochun Wang, Deguan Li, Aimin Meng, Feiyue Fan
Summary: The study suggests that ionizing radiation may induce macrophage senescence, leading to sustained high secretion of SASP in pulmonary macrophages, which may stimulate a fibrotic phenotype in pulmonary fibroblasts.
CELL DEATH & DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Xiaoji Hao, Anfang Ye, Shunfei Yu, Qianying Ni, Jiadi Guo, Xiangguo Wang, Shenyong Gao, Zhongjun Lai, Yaoxian Zhao, Zhiqiang Xuan
Summary: This study followed the case of a worker who developed acute radiation disease and eventually died of leukemia, providing key practical information for understanding the clinical effects of radiation on workers' health. Results showed significant effects of radiation on chromosomal morphology, white blood cell count, and sperm count in the patient. Despite initial improvements after treatment, the patient ultimately succumbed to leukemia, highlighting the long-term risks of ionizing radiation-induced malignancies and the need for enhanced occupational protection for workers in radiographic inspection.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Yuxiao Sun, Lianying Fang, Mengmeng Yang, Ningning He, Jinhan Wang, Manman Zhang, Kaihua Ji, Qin Wang, Yang Liu, Liqing Du, Yan Wang, Chang Xu, Qiang Liu
Summary: RMI1 knockdown leads to increased radiosensitivity and apoptosis, with differentially expressed circRNAs identified in response to IR, indicating the important role of RMI1 in the cellular response to IR and the regulatory mechanism of circRNAs in the radiation response.
DNA AND CELL BIOLOGY
(2021)
Article
Cell Biology
Wenxuan Li, Xinyue Wang, Yinping Dong, Qidong Huo, Tongpeng Yue, Xin Wu, Lu Lu, Junling Zhang, Yu Zhao, Hui Dong, Deguan Li
Summary: Radiotherapy induces premature aging effects in survivors, but effective methods for preventing this are lacking. This study evaluated the therapeutic effects of nicotinamide riboside on premature aging mice. The results showed that nicotinamide riboside treatment reversed aging phenotypes, improved serum metabolism, and restored the regenerative capacity of hematopoietic stem cells. These findings suggest that nicotinamide riboside has potential as a therapeutic agent for radiation-exposed populations and patients receiving radiotherapy.
Article
Multidisciplinary Sciences
Kyuhwan Na, Youngkyu Cho, Dong-Hee Choi, Myung-Jin Park, Ji-hun Yang, Seok Chung
Summary: During radiotherapy, surrounding microenvironments of tumor are exposed to gamma irradiation, impacting blood vessels and their role in tumor nutrition. 3-D models show more accurate effects of radiation on endothelial cells compared to 2-D models, providing insight into radiation-induced endothelial injuries.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Kossi D. Abalo, Sophie Malekzadeh-Milani, Sebastien Hascoet, Serge Dreuil, Tiphaine Feuillet, Cecilia Damon, Helene Bouvaist, Ivan Bouzguenda, Sarah Cohen, Claire Dauphin, Sylvie Di Filippo, Stephanie Douchin, Francois Godart, Patrice Guerin, Pauline Helms, Clement Karsenty, Bruno Lefort, Pierre Mauran, Caroline Ovaert, Jean-Francois Piechaud, Jean-Benoit Thambo, Choonsik Lee, Mark P. Little, Damien Bonnet, Marie-Odile Bernier, Estelle Rage
Summary: Pediatric patients with congenital heart disease who undergo cardiac catheterization (CC) may be exposed to low dose ionizing radiation (LDIR). However, this study found no increased risk of lympho-hematopoietic malignancies and lymphoma associated with LDIR in these patients.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yiran You, Xiaoyuan Sun, Jinghe Xiao, Yu Chen, Xu Chen, Juan Pang, Jiaxin Mi, Yi Tang, Qiannan Liu, Wenhua Ling
Summary: The study found that SAHH inhibition induces endothelial senescence by downregulating hTERT expression, further confirming the important role of endothelial senescence in atherosclerosis.
Review
Biology
Xiaohong Zhang, Xin Li, Chunyan Zheng, Chunzhi Yang, Rui Zhang, Ailian Wang, Jundong Feng, Xiaodan Hu, Shuquan Chang, Haiqian Zhang
Summary: This review summarizes the findings on ionizing radiation-induced ferroptosis, highlighting the increase of hydroxyl radicals, free iron, and lipid metabolic enzymes as well as the role of iron metabolism in regulating ferroptosis. The study suggests that ferroptosis may be the primary form of cell death in the bone marrow under hematopoietic acute radiation syndrome and that DNA damage is not involved in ionizing radiation-induced ferroptosis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Woo Park, Young-Seuk Bae
Summary: This study investigated the roles of histone lysine demethylases JMJD2a and LSD1 in CK2 downregulation-mediated senescence. The results showed that CK2 downregulation reduced the expression of JMJD2a and LSD1 by activating mTOR, resulting in H3K9me3 induction. This study suggests that CK2 is a potential therapeutic target for age-related diseases.
Article
Biochemistry & Molecular Biology
Agnieszka Brojakowska, Cedric J. Jackson, Malik Bisserier, Mary K. Khlgatian, Cynthia Grano, Steve R. Blattnig, Shihong Zhang, Kenneth M. Fish, Vadim Chepurko, Elena Chepurko, Virginia Gillespie, Ying Dai, Brooke Lee, Venkata Naga Srikanth Garikipati, Lahouaria Hadri, Raj Kishore, David A. Goukassian
Summary: The lifetime effects of space irradiation on left ventricular function are unknown. This study aimed to investigate the cardiac effects induced by space-type irradiation and found that all irradiated groups showed impaired global left ventricular systolic function at different time points. Furthermore, mice exposed to space-type irradiation exhibited elevated levels of cardiac fibrosis, inflammation, and hypertrophy markers. These findings suggest that space-type irradiation may induce cardiac remodeling processes commonly associated with diastolic dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Ashley B. Anderson, Julio A. Rivera, Edmund P. Mullin, Collin J. Harrington, Benjamin K. Potter, Jonathan A. Forsberg, Scott M. Tintle
Summary: Patients with complex polytrauma in military and civilian settings are exposed to substantial diagnostic medical radiation, increasing the risk of subsequent malignancy. Currently, there is no coordinated effort to track radiation exposure or long-term surveillance for such patients. This study aims to quantify radiation exposure for combat-wounded servicemembers and determine its correlation with the Injury Severity Score (ISS).
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ellas Spyratou, Agapi Ploussi, Panagiotis Alafogiannis, Hector Katifelis, Sotiria Apostolopoulou, Georgios Bagenakis, Spyridon Rammos, Ioannis Papagiannis, Maria Gazouli, Ioannis Seimenis, Alexandros G. Georgakilas, Efstathios P. Efstathopoulos
Summary: This study investigated the responsiveness of ferredoxin reductase (FDXR) on pediatric population exposed to ionizing radiation during pediatric interventional cardiology procedures. The results showed that the FDXR gene expression varied randomly with the effective dose within the radiation exposure range. Further studies are needed to determine whether FDXR gene expression is an effective biomarker for radiation exposure estimation in pediatric imaging.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Oncology
Abdelilah Aboussekhra, Noura N. Alraouji, Falah H. Al-Mohanna, Huda Al-Khalaf
Summary: The study found that X-rays can normalize the features of active breast stromal fibroblasts by promoting senescence without senescence-associated secretory phenotype (SASP). High doses of X-rays also inhibit the pro-carcinogenic effects of breast stromal fibroblasts and suppress the growth and metastasis of breast cancer.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biology
Catherine A. Hinksman, Richard G. E. Haylock, Michael Gillies
Summary: Exposure to ionizing radiation can harm the cerebrovascular system, but the effects of chronic low-dose radiation exposure, such as that experienced by the public and occupationally exposed individuals, are uncertain. This study used data from the UK National Registry for Radiation Workers to investigate the association between low-dose external radiation exposure and cerebrovascular disease mortality.
RADIATION RESEARCH
(2022)
Article
Oncology
N. Ari Wijetunga, Alexander G. Goglia, Nils Weinhold, Michael F. Berger, Michael Cislo, Daniel S. Higginson, Kiana Chabot, Ahmed M. Osman, Lauren Schaff, Elena Pentsova, Alexandra M. Miller, Simon N. Powell, Adrienne Boire, Jonathan T. Yang
Summary: This study analyzed the genetic characteristics and changes before and after proton craniospinal irradiation (pCSI) in patients with solid tumor leptomeningeal metastasis (LM) to explore their relationship with clinical response. The results showed unique mutations in the cell-free DNA of cerebrospinal fluid (CSF) before and after pCSI, and lower genomic diversity was associated with extended survival after pCSI.
CLINICAL CANCER RESEARCH
(2023)