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Multidisciplinary Sciences
Wei Zhang, Siyu Xia, Wei Xiao, Yali Song, Li Tang, Min Cao, Jing Yang, Shuang Wang, Zhijie Li, Chengchao Xu, Jianqiao Liu, Shanchao Zhao, Chuanbin Yang, Jigang Wang
Summary: This study focuses on the reproductive issues of advanced paternal age and analyzes the molecular and cellular changes associated with aging in the testes of mice. The study discovers various aging-related biological processes and identifies an increased subtype of aging-specific macrophages that contribute to a proinflammatory environment during testicular aging.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cell Biology
Pauline Sararols, Isabelle Stevant, Yasmine Neirijnck, Diane Rebourcet, Annalucia Darbey, Michael K. Curley, Francoise Kuhne, Emmanouil Dermitzakis, Lee B. Smith, Serge Nef
Summary: FLCs and ALCs exhibit significant differences in transcriptional and functional features, including gene expression variations and non-transcriptional events such as intron retention. The FLC-specific expression of Crhr1 and Mc2r receptors suggests a dual regulation of steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Anastasia Magoulopoulou, Xiaoyan Qian, Todia Pediatama Setiabudiawan, Sergio Marco Salas, Chika Yokota, Martin E. Rottenberg, Mats Nilsson, Berit Carow
Summary: This study investigates the local interactions between Mycobacterium tuberculosis (Mtb) and the immune system in the lungs of TB mice using in situ sequencing (ISS) technique. By developing automated analysis pipelines, the researchers were able to determine the spatial distribution of immune transcripts in relation to bacteria. The analysis revealed different patterns of immune activation and antigen presentation in infected and non-infected cells, providing insights into the immune microenvironments of Mtb in the lungs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chloe Mayere, Yasmine Neirijnck, Pauline Sararols, Chris M. Rands, Isabelle Stevant, Francoise Kuhne, Anne-Amandine Chassot, Marie-Christine Chaboissier, Emmanouil T. Dermitzakis, Serge Nef
Summary: Through single-cell RNA sequencing, it was found that XX and XY mouse germ cells diverge transcriptionally early in the differentiation process, with distinct gene expression dynamics. Computational gene regulation network analysis revealed that meiotic genes are regulated by positive and negative master modules. The study also identified sex-specific features in germ cell differentiation in mice.