Article
Food Science & Technology
Jessika Geisebel Oliveira Neto, Juliana Woyames, Cherley Borba Vieira Andrade, Mariana Macedo de Almeida, Larissa Brito Fassarella, Georgia Correia Atella, Christina Maeda Takyia, Isis Hara Trevenzoli, Carmen Cabanelas Pazos-Moura
Summary: Perinatal maternal moderately high-fat diet (mHFD) leads to obesity and fatty liver disease in offspring, but maternal fish oil (FO) supplementation may reduce these disorders. This study examines the effects of FO given to pregnant rats on the offspring's liver at weaning. The results show that mHFD offspring have higher body mass, adiposity, hepatic damage, steatosis, inflammation, and damaged mitochondria. FO partially mitigates hepatic damage and modifies lipid metabolism and mitochondrial morphology.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Dawid Gawlinski, Kinga Gawlinska, Irena Smaga
Summary: Evidence suggests that exposure to a maternal high-fat diet during pregnancy and lactation can induce changes in offspring's brain structure and function, leading to behavioral alterations such as depressive-like phenotype. This study revealed that the maternal high-fat diet triggered several epigenetic mechanisms in the brains of rat offspring, potentially impacting the next generation.
Article
Nutrition & Dietetics
Soniya Xavier, Jasmine Gili, Peter McGowan, Simin Younesi, Paul F. A. Wright, David W. Walker, Sarah J. Spencer, Luba Sominsky
Summary: The study findings indicate that a maternal diet high in fat and sugar had minimal negative effects on newborn pups, while consuming a diet rich in omega-3 fatty acids during pregnancy may be detrimental for some metabolic developmental outcomes in the offspring.
Article
Endocrinology & Metabolism
ChengCheng Lin, Qiang Lei, MengNa Yu, YuHang Lin, HuiZhen Lu, YangPing Huang, Hong Wang, HuiQin Xu, YuanShao Lin
Summary: Maternal consumption of a high-fat diet can lead to multigenerational programming of the HPA axis and behaviors in adult male descendants, including enhanced HPA axis activity, heightened stress responses, and increased susceptibility to depression-like behaviors.
Article
Endocrinology & Metabolism
Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Lin
Summary: The study demonstrated that maternal consumption of a high-fat diet during pregnancy and lactation had multigenerational effects on hippocampal synaptic plasticity and cognitive function in male offspring. Central insulin resistance may play a crucial role in the link between maternal diet and cognitive impairment across generations.
Article
Multidisciplinary Sciences
Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Summary: Maternal and offspring high-fat diet leads to platelet hyperactivation in male mouse offspring, suggesting a novel 'double-hit' effect.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Article
Biochemistry & Molecular Biology
Han Gong, Qichen Yuan, Min Du, Xueying Mao
Summary: Intestinal development is crucial in early life and has long-term effects on overall health. Maternal high-fat diet disrupts intestinal barrier and alters gut microbiota in offspring, but supplementation of polar lipid-enriched milk fat globule membrane (MFGM-PL) can promote intestinal barrier function and modulate gut microbiota in male offspring. Maternal MFGM-PL supplementation improves intestinal development and gut dysbiosis, leading to long-term beneficial effects on offspring's intestinal health.
Article
Nutrition & Dietetics
Qianren Zhang, Lin Ye, Fengzhi Xin, Jiefei Zhou, Baige Cao, Yan Dong, Linxi Qian
Summary: Maternal high-fat diet exposure predisposes offspring to nonalcoholic fatty liver disease. Supplementation of milk fat globule membrane during suckling normalized metabolic parameters and improved hepatic steatosis by suppressing lipogenesis, bolstering antioxidant defenses, and enhancing mitochondrial function in adult offspring exposed to maternal HFD.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Huaqi Zhang, Yutong Wang, Xinyu Zhang, Li Zhang, Xuenuo Zhao, Yan Xu, Peng Wang, Xi Liang, Meilan Xue, Hui Liang
Summary: Maternal folic acid supplementation during pregnancy can improve hepatic steatosis in male offspring exposed to a high-fat diet by modulating the gut microbiota and enhancing intestinal barrier integrity. It reduces LPS leakage and suppresses the expression of the TLR4/NF-κB pathway in the liver, improving lipid metabolism disorders.
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Su-Fan Lin, Chien-Ning Hsu
Summary: Emerging evidence suggests that disturbances in early-life gut microbiota can influence adult disease. In this study, the researchers found that maternal chronic kidney disease (CKD) can lead to offspring hypertension, but perinatal supplementation of propionate can prevent this and reverse established hypertension. This protective effect is associated with increased propionate-generating bacteria, elevated plasma propionate levels, higher expression of the SCFA receptor GPR41, improved gut microbiota diversity, and shifts in composition.
Article
Behavioral Sciences
Arielle R. Strzelewicz, Haley A. Vecchiarelli, Alejandro N. Rondon-Ortiz, Anthony Raneri, Matthew N. Hill, Amanda C. Kentner
Summary: Exposure to adverse childhood experiences can increase the risk for psychiatric disorders and cardiovascular diseases. This study used animal models to investigate the impact of early life stress on maternal care quality and offspring behavior, revealing that multiple early adverse events can have interactive impacts, emphasizing the importance of modeling complex interactions among stressors during development.
HORMONES AND BEHAVIOR
(2021)
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study demonstrates that perinatal garlic oil supplementation can protect offspring against hypertension induced by maternal CKD, by modulating H2S signaling, NO, and gut microbiota. The beneficial effects of garlic oil are associated with enhanced H2S signaling, increased NO bioavailability, and shifts in gut microbiota.
Article
Multidisciplinary Sciences
Marion Guibourdenche, Hiba El Khayat El Sabbouri, Narimane Djekkoun, Hafida Khorsi-Cauet, Veronique Bach, Pauline M. Anton, Jerome Gay-Queheillard
Summary: Maternal exposure to pesticide or a high fat diet may have preliminary impacts on offspring's gut barrier function, but co-exposure to both factors did not exacerbate the effects observed with each factor separately.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Biological
Anne Caroline Alves Vieira, Rafael Oliveira Pinheiro, Nais Lira Soares, Maria Luiza Rolim Bezerra, Davi dos Santos Nascimento, Adriano Francisco Alves, Maria Carolina de Paiva Sousa, Maria Leticia da Veiga Dutra, Marcos dos Santos Lima, Nilcimelly Rodrigues Donato, Jailane de Souza Aquino
Summary: This study evaluated the impact of a maternal high-fat diet on the neurobehavioral, biochemical, and inflammatory parameters of their adult female offspring. The results showed that a maternal high-fat diet had deleterious effects on the neurobehavioral and biochemical parameters of their offspring, which may be associated with the role of organic acids and NF-?B in fetal programming.
PHYSIOLOGY & BEHAVIOR
(2023)