Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1

A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repair

(2015) Huong Phung Thi Thu et al.   NUCLEIC ACIDS RESEARCH

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

(2015) Saed Mohebi et al.   Nature Communications

Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase

(2014) Jonay García-Luis et al.   CELL CYCLE

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

(2014) Nidhi Nair et al.   DNA REPAIR

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once

(2014) Susan E. Tsutakawa et al.   DNA REPAIR

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication

(2014) D. Gritenaite et al.   GENES & DEVELOPMENT

Mlh1-Mlh3, a Meiotic Crossover and DNA Mismatch Repair Factor, Is a Msh2-Msh3-stimulated Endonuclease

(2014) Maria V. Rogacheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheSaccharomyces cerevisiaeMlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions

(2014) Lepakshi Ranjha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GEN1 from a Thermophilic Fungus Is Functionally Closely Similar to Non-Eukaryotic Junction-Resolving Enzymes

(2014) Alasdair D.J. Freeman et al.   JOURNAL OF MOLECULAR BIOLOGY

Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

(2014) Miguel G. Blanco et al.   MOLECULAR CELL

The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

(2014) Christie L. Eissler et al.   MOLECULAR CELL

Visualization of recombination-mediated damage bypass by template switching

(2014) Michele Giannattasio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex

(2014) Tamir Amangyeld et al.   NUCLEIC ACIDS RESEARCH

AtGEN1 and AtSEND1, Two Paralogs in Arabidopsis, Possess Holliday Junction Resolvase Activity

(2014) Markus Bauknecht et al.   PLANT PHYSIOLOGY

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability

(2014) Ying Wai Chan et al.   Nature Communications

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes

(2013) Ulrich Rass   CHROMOSOMA

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

Regulation of Mus81–Eme1 Holliday junction resolvase in response to DNA damage

(2013) Pierre-Marie Dehé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate specificity of the MUS81-EME2 structure selective endonuclease

(2013) A. Pepe et al.   NUCLEIC ACIDS RESEARCH

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

(2013) Elizabeth Garner et al.   Cell Reports

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

(2012) Y. Kim et al.   BLOOD

Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase

(2012) Kseniya Zakharyevich et al.   CELL

The OsGEN-L protein from Oryza sativa possesses Holliday junction resolvase activity as well as 5'-flap endonuclease activity

(2012) Y. Yang et al.   JOURNAL OF BIOCHEMISTRY

Mus81-Mms4 Functions as a Single Heterodimer To Cleave Nicked Intermediates in Recombinational DNA Repair

(2012) E. K. Schwartz et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

(2012) María Gallo-Fernández et al.   NUCLEIC ACIDS RESEARCH

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

(2011) Erin K. Schwartz et al.   CHROMOSOMA

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

(2011) Thomas Wechsler et al.   NATURE

Meiotic Recombination Intermediates Are Resolved with Minimal Crossover Formation during Return-to-Growth, an Analogue of the Mitotic Cell Cycle

(2011) Yaron Dayani et al.   PLoS Genetics

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

Double Holliday junctions are intermediates of DNA break repair

(2010) Malgorzata Bzymek et al.   NATURE

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic and functional interactions between Mus81-Mms4 and Rad27

(2010) M.-J. Kang et al.   NUCLEIC ACIDS RESEARCH

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

(2009) R. Prakash et al.   GENES & DEVELOPMENT

Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination

(2009) Sabrina L. Andersen et al.   MOLECULAR CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant

(2009) Alexander Lorenz et al.   NUCLEIC ACIDS RESEARCH

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease

(2008) K. T. Ehmsen et al.   NUCLEIC ACIDS RESEARCH