期刊
CLINICAL EPIDEMIOLOGY
卷 10, 期 -, 页码 863-874出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CLEP.S151890
关键词
epidemiology; pharmacoepidemiology; electronic health care database; cross-national study; population-based study; type 2 diabetes mellitus
资金
- POCTEFA Programme [REFBIO EFA 237/11]
- Instituto de Salud Carlos III [PI15/02196]
- Spanish thematic network REDIS-SEC (Instituto de Salud Carlos III, Spanish Ministry of Health) [RD12/0001, RD16/0001]
- Spanish thematic network REDIS-SEC (European Regional Development Fund)
- Departamento de Educacion, Politica Linguistica y Cultura del Gobierno Vasco [IT620-13]
Aim: The EPICHRONIC (EPIdemiology of CHRONIC diseases) project investigated the possibility of developing common procedures for French and Spanish electronic health care data-bases to enable large-scale pharmacoepidemiological studies on chronic diseases. A feasibility study assessed the prevalence of type 2 diabetes mellitus (T2DM) in Navarre and the Basque Country (Spain) and the Midi-Pyrenees region (France). Patients and methods: We described and compared database structures and the availability of hospital, outpatient, and drug-dispensing data from 5.9 million inhabitants. Due to differences in database structures and recorded data, we could not develop a common procedure to estimate T2DM prevalence, but identified an algorithm specific to each database. Patients were identified using primary care diagnosis codes previously validated in Spanish databases and a combination of primary care diagnosis codes, hospital diagnosis codes, and data on exposure to oral antidiabetic drugs from the French database. Results: Spanish and French databases (the latter termed Systeme National d'Information Inter-Regimes de l'Assurance Maladie [SNIIRAM]) included demographic, primary care diagnoses, hospital diagnoses, and outpatient drug-dispensing data. Diagnoses were encoded using the International Classification of Primary Care (version 2) and the International Classification of Diseases, version 9 and version 10 (ICD-9 and ICD-10) in the Spanish databases, whereas the SNIIRAM contained ICD-10 codes. All data were anonymized before transferring to researchers. T2DM prevalence in the population over 20 years was estimated to be 6.6-7.0% in the Spanish regions and 6.3% in the Midi-Pyrenees region with similar to 2% higher estimates for males in the three regions. Conclusion: Tailored procedures can be designed to estimate the prevalence of T2DM in population-based studies from Spanish and French electronic health care records.
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