Review
Gastroenterology & Hepatology
Jonathan Van Hecke, Lucas Wauters, Gigi Veereman
Summary: This study collected real-world data of children and adolescents with inflammatory bowel disease and studied their treatment outcomes. The results showed a significant decrease in disease activity after 1 year, with no significant differences between 1-year and 5-year follow-ups.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Brunette Katsandegwaza, William Horsnell, Katherine Smith
Summary: This article reviews the current murine models used for studying human inflammatory bowel disease, including chemical-induced models, gene-deficient models, and cell transfer models. The application and limitations of these models in understanding the disease pathogenesis and developing new clinical treatment strategies are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Joyce Wing Yan Mak, Meng-Tzu Weng, Shu Chen Wei, Siew Chien Ng
Summary: The study found no cases of COVID-19 infection among IBD patients in Hong Kong and Taiwan. Most IBD patients in Hong Kong and Taiwan were on medication, with recommendations to continue their medication as prescribed during the pandemic.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jordi Rimola, Joana Torres, Shankar Kumar, Stuart A. Taylor, Torsten Kucharzik
Summary: Endoscopy, the reference standard for inflammatory bowel disease (IBD) diagnosis and assessment, has limitations. Cross-sectional imaging techniques such as magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) are better tolerated, safer, and can examine the entire bowel. They also allow visualization of the small-bowel and assessment of extraintestinal disease, making them viable alternatives to colonoscopy for diagnosing and monitoring Crohn's disease.
Review
Gastroenterology & Hepatology
Simeng Lin, Louis Hs Lau, Neil Chanchlani, Nicholas A. Kennedy, Siew C. Ng
Summary: This review summarizes the risk and outcomes of COVID-19 in patients with IBD, as well as the latest guidance on SARS-CoV-2 vaccines. Certain medications may be associated with adverse outcomes to COVID-19, while a decrease in endoscopy procedures has led to missed cancer cases.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Article
Medicine, General & Internal
Maria Chaparro, Ana Garre, Andrea Nunez Ortiz, Maria Teresa Diz-Lois Palomares, Cristina Rodriguez, Sabino Riestra, Milagros Vela, Jose Manuel Benitez, Estela Fernandez Salgado, Eugenia Sanchez Rodriguez, Vicent Hernandez, Rocio Ferreiro-Iglesias, Angel Ponferrada Diaz, Jesus Barrio, Jose Maria Huguet, Beatriz Sicilia, Maria Dolores Martin-Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernandez-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Monica Sierra, Jose Luis Cabriada, Mariam Aguas, Raquel Vicente, Merce Navarro-Llavat, Ana Echarri, Fernando Gomollon, Elena Guerra del Rio, Concepcion Pinero, Maria Jose Casanova, Katerina Spicakova, Jone Ortiz de Zarate, Emilio Torrella Cortes, Ana Gutierrez, Horacio Alonso-Galan, Alvaro Hernandez-Martinez, Jose Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Marti Romero, Pilar Robledo, Orencio Bosch, Nuria Jimenez, Maria Esteve Comas, Jose Maria Duque, Ana Maria Fuentes Coronel, Manuela Josefa Sampedro, Eva Sese Abizanda, Belen Herreros Martinez, Liliana Pozzati, Hipolito Fernandez Rosaenz, Belen Crespo Suarez, Pilar Lopez Serrano, Alfredo J. Lucendo, Margarita Munoz Vicente, Fernando Bermejo, Jose Joaquin Ramirez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torra Alsina, Nuria Maroto, Juan Nerin de la Puerta, Elena Castro, Ignacio Marin-Jimenez, Belen Botella, Amparo Sapina, Noelia Cruz, Jose Luis F. Forcelledo, Abdel Bouhmidi, Carlos Castano-Milla, Veronica Opio, Isabel Nicolas, Marcos Kutz, Alfredo Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Dominguez, Maria Teresa Novella Duran, Silvia Rodriguez Mondejar, Francisco J. Martinez-Cerezo, Lilyan Kolle, Miriam Sabat, Cesar Ledezma, Eduardo Iyo, Oscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blazquez Gomez, Eva Maria Zapata, Maria Jose Alcala, Cristina Martinez Pascual, Maria Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernandez Camba, Luis Hernandez, Maria Tejada, Alberto Mir, Maria Luisa Galve, Marta Soler, Daniel Hervias, Jose Antonio Gomez-Valero, Manuel Barreiro-de Acosta, Fernando Rodriguez-Artalejo, Esther Garcia-Esquinas, Javier P. Gisbert
Summary: The study found a high incidence of inflammatory bowel disease (IBD) in Spain, similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, especially in cases of Crohn's disease (CD) and in hospitals with high resources, which are much higher than previously reported.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Zhaobei Cai, Shu Wang, Jiannan Li
Summary: Inflammatory bowel disease (IBD) is a global disease that has attracted significant research interest. Constant research has led to a better understanding of the disease and promoted the development of conventional and novel treatments. From small molecules to cell therapy, diverse therapeutic options are emerging, offering new hope for treating IBD.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Jesus K. Yamamoto-Furusho, Norma N. Parra-Holguin, Fabian Juliao-Banos, Fabian Puentes, Rocio Lopez, Francisco Bosques-Padilla, Esther A. Torres, Humberto Nieves-Jimenez, Guillermo R. Veitia-Velasquez, Maria L. Jara-Alba, Socrates Bautista, Felipe N. Pinol-Jimenez, Pablo Salgado-Rosado, Keyla C. Villa-Ovalles, Yudelka A. Abreu-Martinez, Zunilda Borges, Santiago Davila-Bedoya, Guillermo Otoya-Moreno, Beatriz Iade-Vergara
Summary: This study in Latin America and the Caribbean described the epidemiological and clinical characteristics of IBD in several countries, showing differences in CD and UC prevalence among countries, with patients from the Caribbean exhibiting unique clinical features.
Review
Nutrition & Dietetics
Vilk Janne da Silva Barros, Juliana Soares Severo, Pedro Henrique Moraes Mendes, Alda Cassia Alves da Silva, Kelly Beatriz Vieira de Oliveira, Jose Miguel Luz Parente, Murilo Moura Lima, Emidio Marques Matos Neto, Armenio Aguiar dos Santos, Moises Tolentino Bento da Silva
Summary: This review systematically evaluates the effectiveness of dietary interventions in attenuating inflammatory biomarkers in patients with inflammatory bowel diseases based on available clinical trials. It was found that some dietary interventions can reduce inflammatory markers.
Review
Biochemistry & Molecular Biology
Eun Goo Lee, Young Cheol Yoon, Jihyun Yoon, Seul Ji Lee, Yu-Kyoung Oh, Sung Won Kwon
Summary: Researchers aim to identify the etiology of inflammatory bowel diseases, with dysregulation of the immune system in the host gastrointestinal tract believed to be a major causative factor. Using high-resolution mass spectrometry to observe alterations in global lipidomics can help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases. Evaluating the characteristics of previous clinical trials on these diseases could assist in establishing criteria for future studies.
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Infectious Diseases
Keyu Ren, Chunming Yong, Yanting Wang, Hongyun Wei, Kun Zhao, Baoguo He, Mingjuan Cui, Yunqing Chen, Jin Wang
Summary: The objective of this review was to explore the association between CMVP and immunosuppressive therapy in IBD patients, and to emphasize the significance of CMV as an opportunistic pathogen and its potential impact on morbidity and mortality. Records and clinical trajectories related to CMVP in IBD patients were retrieved from the PubMed database, with no language barriers. Our findings showed that CMVP primarily occurs during Crohn's disease remission and azathioprine is the main immunosuppressant linked to CMV reactivation. Prompt antiviral therapy can greatly improve patient outcomes, and CMV vaccine might serve as a potential prevention strategy.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Heidi S. Christensen, Martin Bogsted, Jean-Frederic Colombel, Tine Jess, Kristine H. Allin
Summary: The incidence and prevalence of IBD have increased in Denmark over the past two decades, and the IBD population is shifting towards an older age.
Review
Biochemistry & Molecular Biology
Magdalena Kurnik-Lucka, Pawel Pasieka, Patrycja Laczak, Marcin Wojnarski, Michal Jurczyk, Krzysztof Gil
Summary: The dopaminergic system may play a significant role in inflammatory bowel disease, but its impact is currently underestimated. Further in-depth observational studies are needed to support this notion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yang Chen, He Gao, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Hao Zhang, Wei Chen, Bo Yang
Summary: This review comprehensively summarizes the epidemic trend and pathogenesis of inflammatory bowel disease (IBD), and highlights the potential regulatory mode and mechanisms of lactic acid bacteria (LAB) in alleviating IBD. LAB exhibits numerous advantages, such as producing bioactive metabolites, regulating gut immunity, protecting the intestinal mechanical barriers, inhibiting oxidative damage, and restoring unbalanced gut microbiota. The review also provides recommendations for screening effective LAB, controlling optimal intake, encapsulating LAB, investigating mechanisms, and improving clinical study design to improve the lives of IBD patients.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)