Synthetic self-adjuvanting glycopeptide cancer vaccines

Antibody Induction Directed against the Tumor-Associated MUC4 Glycoprotein

(2015) Hui Cai et al.   CHEMBIOCHEM

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

(2015) Pamela Thompson et al.   CHEMICAL COMMUNICATIONS

Synthetic Multivalent Glycopeptide-Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells

(2014) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist

(2014) Abu-Baker M. Abdel-Aal et al.   CHEMBIOCHEM

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

(2014) David M. McDonald et al.   CHEMICAL COMMUNICATIONS

Synthesis and Characterisation of Self-Assembled and Self-Adjuvanting Asymmetric Multi-Epitope Lipopeptides of Ovalbumin

(2014) Sharareh Eskandari et al.   CHEMISTRY-A EUROPEAN JOURNAL

The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses

(2014) Brendon Y Chua et al.   IMMUNOLOGY AND CELL BIOLOGY

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy

(2014) Regan J Anderson et al.   Nature Chemical Biology

Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

(2014) Zhifang Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A quantitative and site-specific chemoenzymatic glycosylation approach for PEGylated MUC1 peptides

(2014) Claudia Bello et al.   Chemical Science

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

(2013) Tzu-Yu Liu et al.   BIOMACROMOLECULES

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

(2013) Rebecca M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of Sialylated Tumor-Associated Glycosylamino Acids

(2013) Leo Corcilius et al.   ORGANIC LETTERS

MUC1 and metastatic cancer

(2013) Teresa M. Horm et al.   Cell Adhesion & Migration

Harnessing the Power of the Immune System to Target Cancer

(2012) Gregory Lizée et al.   Annual Review of Medicine

Synthesis and Immunological Evaluation of Self-Assembling and Self-Adjuvanting Tricomponent Glycopeptide Cancer-Vaccine Candidates

(2012) Brendan L. Wilkinson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fully Synthetic Self-Adjuvanting Thioether-Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells

(2012) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mucin-based Targeted Pancreatic Cancer Therapy

(2012) Maria P. Torres et al.   CURRENT PHARMACEUTICAL DESIGN

MUC1 immunotherapy is here to stay

(2012) Takashi Kimura et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Design of Fully Synthetic, Self-Adjuvanting Vaccine Incorporating the Tumor-Associated Carbohydrate Tn Antigen and Lipoamino Acid-Based Toll-like Receptor 2 Ligand

(2012) Abu-Baker M. Abdel-Aal et al.   JOURNAL OF MEDICINAL CHEMISTRY

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse

(2011) Qianli Wang et al.   ACS Chemical Biology

Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer

(2011) Brendan L. Wilkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

Synthesis of Tn/T Antigen MUC1 Glycopeptide BSA Conjugates and Their Evaluation as Vaccines

(2011) Hui Cai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

(2010) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of MUC1–lipopeptide chimeras

(2010) Brendan L. Wilkinson et al.   CHEMICAL COMMUNICATIONS

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

(2010) Moses O Oyewumi et al.   Expert Review of Vaccines

Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity

(2010) Olivier Renaudet et al.   PLoS One

A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

(2009) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancer

(2009) Aziz Alami Chentoufi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

(2008) Ilham Bettahi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Self-Adjuvanting Lipopeptide Vaccines

(2008) Peter Moyle et al.   CURRENT MEDICINAL CHEMISTRY