Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Rebecca Voelker
Summary: This article describes diabetic foot ulcers and their evaluation and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Dermatology
Jaroslaw Pasek, Sebastian Szajkowski, Grzegorz Cieslar
Summary: Diabetes mellitus is a common metabolic disease, and one of its most serious complications is diabetic foot ulcer (DFU). This study aimed to compare the efficacy of topical oxygen therapy and topical ozone therapy for the treatment of DFU and calculate the financial costs of both methods. The study included 85 patients with hard-to-heal diabetic foot ulcers, and the results showed that both topical oxygen therapy and topical ozone therapy significantly reduced ulcer area and pain intensity. Both methods were considered cost-effective due to their moderate cost.
DERMATOLOGIC THERAPY
(2023)
Article
Multidisciplinary Sciences
Valentina Guarnotta, Stefano Radellini, Enrica Vigneri, Achille Cernigliaro, Felicia Panto, Salvatore Scondotto, Piero Luigi Almasio, Giovanni Guercio, Carla Giordano
Summary: The aim was to analyze changes in the incidence, management, and mortality of DFU in Sicilian Type 2 diabetic patients hospitalized between 2008-2013 and 2014-2019. The study found that age at onset of diabetic foot ulcer, eGFR values, and CKD are the principal risk factors for mortality in patients with DFU.
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sirbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Summary: This study utilizes single-cell RNA sequencing to reveal the distribution of specific populations of fibroblasts and macrophages in diabetic foot ulceration (DFU) patients and identifies their crucial roles in wound healing.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Qian Yu, Guo-hong Qiao, Min Wang, Li Yu, Yaoxiang Sun, Hui Shi, Tie-liang Ma
Summary: Diabetic foot ulcer poses a worldwide challenge in clinical medicine due to the ineffective traditional treatments. Researching the pathogenesis and molecular mechanisms of stem cell therapy for diabetic foot is of great importance in maximizing the repair properties of stem cells. Additionally, effective application modalities are crucial for improving stem cell survival and viability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Xuan Wang, Chong-Xi Yuan, Bin Xu, Zhi Yu
Summary: Diabetic foot ulceration is a severe complication of diabetes that requires comprehensive treatment and preventive measures. Classification is the important foundation for clinical diagnosis and management, focusing on common risk factors can help prevent and manage the condition in a timely manner. Preventive education and effective management approaches are equally important.
WORLD JOURNAL OF DIABETES
(2022)
Article
Dermatology
David Dayya, Owen J. O'Neill, Tania B. Huedo-Medina, Nusrat Habib, Joanna Moore, Kartik Iyer
Summary: Diabetic foot ulcerations can lead to severe complications, and debridement is a common treatment method involving both nonmechanical and mechanical approaches. These methods help promote wound healing and reduce complications.
ADVANCES IN WOUND CARE
(2022)
Article
Biotechnology & Applied Microbiology
Yi Xu, Kang Han, Yongming Zhou, Jian Wu, Xin Xie, Wei Xiang
Summary: Diabetic foot ulcers (DFUs) are common complications of diabetes. Recent advancements in computerized classification based on deep learning methods have shown promising results for identifying infection and ischemia in DFUs. This study proposes the use of class knowledge banks (CKBs) to improve the performance of DFU infection and ischemia classifications by effectively extracting and representing class knowledge.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
Summary: The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). The study also investigated the effectiveness of negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) in the treatment of diabetic foot ulcers. They found new risk factors for DFUs and concluded that the combination therapy could accelerate wound healing and reduce mortality rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Malakai Sovaki Ranuve, Masoud Mohammadnezhad
Summary: This study examines the perception of healthcare workers in Rotuma, Fiji on diabetic foot ulcers and foot care, revealing a lack of significant in-depth knowledge and challenges in practice. Insufficient resources and professional development opportunities negatively impact the quality of foot care services provided by healthcare workers.
Review
Pharmacology & Pharmacy
Danielle Dixon, Michael Edmonds
Summary: Recent evidence-based treatments for diabetic foot ulcers have emerged from multicentre, randomised, controlled trials, highlighting new advances in wound therapy. The overview of current and future pharmacotherapies includes proposed mechanisms of action and supporting evidence for various treatments. Looking forward, novel therapies utilizing nanotechnology and bioactive agents may provide possibilities for pharmacotherapy in the future.
Review
Microbiology
Cassandra Pouget, Catherine Dunyach-Remy, Alix Pantel, Adeline Boutet-Dubois, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Paul Loubet
Summary: Diabetic foot ulcers present a growing public health issue, with multidrug-resistant bacteria and biofilm formation as complications. New alternative solutions, such as antibiofilm approaches, can help prevent biofilm formation, reduce chronicity of wounds, and enhance the healing process.
FRONTIERS IN MICROBIOLOGY
(2021)