Review
Neurosciences
Garikoitz Azkona, Rosario Sanchez-Pernaute
Summary: Animal models are crucial in neuroscience research, but there are recurring issues in data collection and interpretation, a lack of biomarkers, and an over-reliance on mice, leading to low translation efficiency. Non-human primates, with their higher brain complexity and similarity to humans, can provide more relevant translational information. Therefore, resources for training, education, husbandry, and data sharing should be prioritized to improve translational efficiency.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Cell Biology
James A. Saba, Kifayathullah Liakath-Ali, Rachel Green, Fiona M. Watt
Summary: Stem cells are characterized by their ability to self-renew and differentiate into different cell types, and recent studies have shown that their behavior is closely tied to the regulation of protein synthesis by the ribosome. Understanding how translation mechanisms control stem cell function, including pluripotency and differentiation, may provide insights into mechanisms of tumorigenesis.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Cell Biology
Teng Liu, Jingni Wu, Yangjun Wu, Wei Hu, Zhixiao Fang, Zishan Wang, Chunjie Jiang, Shengli Li
Summary: The study presents the development of a comprehensive database called LncPep for investigating and discovering peptides encoded by lncRNAs. The database offers user-friendly searching/browsing interface, prediction and BLAST modules for exploring novel lncRNAs and peptides, as well as annotations for lncRNAs, peptides, and supporting evidence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Paul J. Beggs, Bernard Clot, Mikhail Sofiev, Fay H. Johnston
Summary: One of the adverse impacts of climate change on human health is the increase in allergic respiratory diseases. This is caused by the effects of increased atmospheric carbon dioxide concentration and air temperature on airborne allergens such as pollen and fungal spores. This review discusses these effects and explores three translational mitigation approaches for improved health outcomes.
Article
Multidisciplinary Sciences
Surajit Chatterjee, Adrien Chauvier, Shiba S. Dandpat, Irina Artsimovitch, Nils G. Walter
Summary: In bacteria, the interaction between RNA polymerase and ribosome regulates gene expression through transcription-translation coupling. This coupling is mainly achieved by RNA polymerase promoting the binding of the ribosomal 30S subunit to antagonize ribosome binding site occlusion induced by a riboswitch, thereby facilitating translation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Sonia Coni, Federica A. Falconio, Marta Marzullo, Marzia Munafo, Benedetta Zuliani, Federica Mosti, Alessandro Fatica, Zaira Ianniello, Rosa Bordone, Alberto Macone, Enzo Agostinelli, Alessia Perna, Tanja Matkovic, Stephan Sigrist, Gabriella Silvestri, Gianluca Canettieri, Laura Ciapponi
Summary: Expansion of CCTG repeats in the CNBP gene leads to DM2 and is associated with impaired polyamine metabolism. Depletion of CNBP in Drosophila muscles causes aging-dependent locomotor defects correlated with impaired polyamine metabolism. This function of CNBP is evolutionarily conserved in vertebrates and has relevance for CNBP-related pathophysiological conditions.
Article
Chemistry, Multidisciplinary
Kyoung Sub Kim, Kun Na, You Han Bae
Summary: Oral administration of pharmaceuticals is challenging due to solubility, size, enzymes, and transporters. Efforts have been made to enhance oral bioavailability using nanoparticles with specific and nonspecific uptake pathways. However, translating results from animal models to humans is difficult and inconsistent. Parameters for translational potential in designing oral nanoparticles are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Multidisciplinary Sciences
Lara A. Ray, Steven J. Nieto, Erica N. Grodin
Summary: Alcohol and substance use disorders pose challenges in effective treatment due to their heterogeneous nature. Efforts to classify addiction subtypes and apply neuroscience frameworks have the potential to advance precision medicine in this field. The use of deep behavioral phenotyping in neuroscience-informed batteries shows promise for understanding addiction on a clinical neuroscience level.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shannon E. Wright, Caitlin M. Rodriguez, Jeremy Monroe, Jiazheng Xing, Amy Krans, Brittany N. Flores, Venkatesha Barsur, Magdalena I. Ivanova, Kristin S. Koutmou, Sami J. Barmada, Peter K. Todd
Summary: CGG repeat expansions in the FMR1 gene are associated with the neurodegenerative disease FXTAS. These repeats can form stable RNA secondary structures and undergo aberrant translation in the absence of an AUG start codon, producing aggregate-prone peptides that accumulate in neuronal inclusions and contribute to neurotoxicity. The most abundant RAN translation product, FMRpolyG, is shown to be less toxic when generated from a construct with a non-repetitive alternating codon sequence instead of the CGG repeat. Investigation into the mechanism of this differential toxicity reveals translational frameshifts within the CGG repeat and the formation of chimeric R/G peptides, both of which contribute to CGG repeat-associated toxicity in FXTAS and related disorders.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Immunology
Dejiu Zhang, Lei Zhu, Yin Wang, Peifeng Li, Yanyan Gao
Summary: This article provides a comprehensive understanding of the molecular basis and complexity of SARS-CoV-2 protein translation. It discusses how the virus inhibits the translation of host mRNA to optimize the translation of its own mRNA and block cellular innate immune response. The potential of translational components as targets for therapeutic interventions is also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Guillermo Fernandez Rodriguez, Bianca Cesaro, Alessandro Fatica
Summary: Despite its discovery in the early 1970s, the importance of m(6)A modification in regulating mRNA translation has only recently gained attention in oncology. This chemical modification can control all aspects of mRNA maturation and its alteration may contribute to gene expression changes observed in cancer. In this review, the role of m(6)A in translation regulation and its cancer-related functions are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Summary: In the era of precision medicine, drug discovery and development are undergoing unprecedented opportunities and challenges. By adopting new technologies and methods, the transition from serendipity-driven to data-driven approach is achieved, promoting the development of modern Translational Precision Medicine methods.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Geena Skariah, Peter K. Todd
Summary: Protein metabolism plays crucial roles in aging and neurodegeneration, with changes in protein synthesis efficiency and accuracy less understood than degradation. Interventions that prolong lifespan often involve preemptively decreasing protein synthesis rates to harmonize with age-related declines in catabolism. Emerging technologies are revealing mRNA-specific changes in translation rates across tissues, pointing to key interactions between catabolic and anabolic pathways that contribute to functional decline.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2021)
Article
Biochemistry & Molecular Biology
Yinghui Peng, Miaoqi Huang, Jiaoyan Xie, Beiyi Shu, Xiaojun Wang, Yumei Liao, Junyu Xu, Lei Shi
Summary: This study investigates the translation patterns of critical synaptic receptors during brain development and behavioral stress. The results show that most receptor subunits exhibit changes in mRNA, translation, and protein levels. Translation of Gria1, Gria2, Grin1, Grin2a, Gabra1, and Gabrg2 significantly contributes to their protein levels. Additionally, stress has a greater impact on translational and protein levels in the prefrontal cortex.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Chulmin Cho, Harashdeep K. Deol, Loren J. Martin
Summary: There is a gap between translating basic science research into effective pain therapies in humans, with a need to fully consider biological, psychological, and social factors in pain research. Studies show that the pain experience is highly complex, requiring efforts to address multiple components and interactors to fully understand its complexity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Julia Kravchenko, Amy P. Abernethy, Maria Fawzy, H. Kim Lyerly
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2013)
Article
Respiratory System
Miriam J. Johnson, J. Martin Bland, Stephen G. Oxberry, Amy P. Abernethy, David C. Currow
EUROPEAN RESPIRATORY JOURNAL
(2013)
Article
Oncology
Micael Lopez-Acevedo, Laura J. Havrilesky, Gloria Broadwater, Arif H. Kamal, Amy P. Abernethy, Andrew Berchuck, Angeles Alvarez Secord, James A. Tulsky, Fidel Valea, Paula S. Lee
GYNECOLOGIC ONCOLOGY
(2013)
Editorial Material
Hematology
Thomas W. LeBlanc, Amy P. Abernethy
Article
Health Care Sciences & Services
Timothy P. Pearman, Jennifer L. Beaumont, Diane Paul, Amy P. Abernethy, Paul B. Jacobsen, Karen L. Syrjala, Jamie Von Roenn, David Cella
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Meeting Abstract
Health Care Sciences & Services
Arif Kamal, Janet Bull, Amy Abernethy
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Meeting Abstract
Health Care Sciences & Services
Arif Kamal, Ryan Nipp, Janet Bull, Amy Abernethy
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Amy P. Abernethy, Janet Bull, Elizabeth Whitten, Rebecca Shelby, Jane L. Wheeler, Donald H. Taylor
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Amy P. Abernethy, David C. Currow, Tania Shelby-James, Debra Rowett, Frank May, Gregory P. Samsa, Roger Hunt, Helena Williams, Adrian Esterman, Paddy A. Phillips
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Arif H. Kamal, David C. Currow, Christine S. Ritchie, Janet Bull, Amy P. Abernethy
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Miriam J. Johnson, J. Martin Bland, Stephen G. Oxberry, Amy P. Abernethy, David C. Currow
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Miriam J. Johnson, Amy P. Abernethy, David C. Currow
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2013)
Article
Health Care Sciences & Services
Catherine M. Burns, Amy P. Abernethy, Eleanora Dal Grande, David C. Currow
PALLIATIVE MEDICINE
(2013)
Article
Multidisciplinary Sciences
April K. S. Salama, Nicole de Rosa, Randall P. Scheri, Scott K. Pruitt, James E. Herndon, Jennifer Marcello, Douglas S. Tyler, Amy P. Abernethy
Article
Economics
Nan E. Rothrock, Sally E. Jensen, Jennifer L. Beaumont, Amy P. Abernethy, Paul B. Jacobsen, Karen Syrjala, David Cella