Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Immunology
Fan Mao, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Jingchen Song, Shiwei Fu, Zhiming Xiang, Shu Xiao, Yongbo Bao, Ziniu Yu, Yang Zhang
Summary: This study reveals the regulatory mechanisms of the Hippo pathway in immune responses of Crassostrea hongkongensis hemocytes, highlighting its importance in maintaining immune homeostasis and orchestrating hemocytic functions. It also demonstrates the divergence of the Hippo pathway's roles in marine invertebrate immunity from mammalian observations, indicating the need for further comparative studies across species.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlueter
Summary: OTUB1 is identified as a potent novel regulator of DCs during infectious and inflammatory diseases. It promotes NF-kappa B activity, regulates cytokine production, and impacts the response to pathogens.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yi Guo, Xia-Nan Zhang, Shan Su, Zi-Lun Ruan, Ming-Ming Hu, Hong-Bing Shu
Summary: Upon viral infection, the levels of beta-adrenergic hormones and their receptors decrease, inhibiting the innate antiviral response. Increased levels of beta-adrenergic hormones activate PKA kinase, which phosphorylates MITA and VISA, suppressing the innate immune response to DNA and RNA viruses. These findings provide insights into the regulatory mechanisms of innate antiviral responses and the increased susceptibility to viral infection in stressful situations.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patrick Haider, Julia B. Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Summary: IL-4R alpha plays a homeostatic role in regulating the lifespan of monocytes, and its absence leads to a reduction in monocyte numbers and affects the occurrence of inflammatory responses.
Review
Allergy
Timothy N. Perkins, Mason L. Donnell, Tim D. Oury
Summary: Asthma affects nearly 400 million people worldwide, with the majority of patients exhibiting a type 2-high phenotype and severe asthma often being associated with a type 2-low phenotype. The receptor for advanced glycation endproducts (RAGE) plays a significant role in asthma pathogenesis and allergic airway disease, especially in severe neutrophilic asthma.
Article
Multidisciplinary Sciences
Yu-Lin Yang, Li -Bo Cao, Wen-Rui He, Li Zhong, Yi Guo, Qing Yang, Hong -Bing Shu, Ming-Ming Hu
Summary: The current understanding of nucleic acid-mediated innate immunity is that the binding of intracellular sensors to nucleic acids is enough to activate them. However, this study reveals that the endocytosis of viruses or foreign DNA provides a priming signal for the activation of the DNA sensor cGAS in the innate immune response. This finding demonstrates that the activation of cGAS following endocytosis requires tyrosine phosphorylation mediated by the V-ATPase-SYK pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Shangran Zhang, Runan Zheng, Yanhong Pan, Hongbin Sun
Summary: The stimulator of interferon genes (STING) is a critical protein that activates the immune system and participates in the inflammatory response. It can modulate the inflammation-preferred translation program or induce the secretion of type I interferons and proinflammatory factors through different pathways. This review summarizes the potential value of STING inhibitors in preventing and treating infectious diseases, psoriasis, systemic lupus erythematosus, non-alcoholic fatty liver disease, and other inflammatory and autoimmune diseases, based on the structure, location, function, genotype, and regulatory mechanism of STING.
Review
Biochemistry & Molecular Biology
Thomas D. Gilmore
Summary: NF-kappa B is extensively studied for its roles in cancer development and is often constitutively or aberrantly activated in human cancers. Activation can occur due to mutations in NF-kappa B factors, upstream regulators, or pathways impacting NF-kappa B. Despite being considered an anticancer strategy, inhibition of NF-kappa B has had limited success in cancer treatment.
Review
Pharmacology & Pharmacy
Aleksandra Kusiak, Gareth Brady
Summary: The human innate immune response can be activated by various stimuli, such as PAMPs and DAMPs. These stimuli trigger intracellular signaling pathways that activate transcription factors from the NF-kappa B and IRF families, which play crucial roles in inflammation and antiviral response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Xin Tian, Qiongxiao Huang, Jingyao Liang, Jianqin Wang, Jing Zhang, Yan Yang, Qianru Ye, Suling He, Junlong Li, Zhouwei Wu, Yumei Liu
Summary: The dysregulation of skin microflora and Staphylococcus aureus infection in patients with AD have become research hotspots. Staphylococcus aureus infection can cause inflammatory damage in keratinocytes, leading to a vicious cycle.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Corinne J. J. Smith, Nikki Ross, Ali Kamal, Kevin Y. Kim, Elizabeth Kropf, Pascal Deschatelets, Cedric Francois, William J. Quinn, Inderpal Singh, Anna Majowicz, Federico Mingozzi, Klaudia Kuranda
Summary: AAV gene transfer shows promise in treating genetic diseases, but the host immune response poses challenges. This study characterizes the innate immune response to AAV in human whole blood, finding that high levels of neutralizing antibodies can increase inflammation and vector uptake. Inhibiting the complement pathway may be a strategy for reducing immunogenicity in AAV-based therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Fritzlaine C. Roche, Tamia A. Harris-Tryon
Summary: Vitamin A is crucial for skin immunity, deficiencies can lead to impaired immune response and increased susceptibility to skin infections. Recent evidence shows that vitamin A and its derivatives play a role in innate immune regulation by promoting skin immunity and sustaining the skin microbiome.
Article
Chemistry, Multidisciplinary
Rui Zhang, Xianteng Hou, Changwan Wang, Jiaxin Li, Junyan Zhu, Yingbo Jiang, Fajian Hou
Summary: This study identifies ATP13A1 as an important regulator of the stability and activation of RIG-I pathway, highlighting its crucial role in antiviral innate immune response.
Letter
Surgery
Sammy Al-Benna
ANNALS OF PLASTIC SURGERY
(2021)
Article
Dermatology
Sammy Al-Benna
Summary: The study found that ACE2 gene expression is higher in human skin keratinocytes and basal cells, potentially leading to direct susceptibility to SARS-CoV-2 infection, especially in conditions of skin barrier dysfunction, making them a potential target for the coronavirus.
ADVANCES IN SKIN & WOUND CARE
(2021)
Article
Surgery
Siting Yang, Marie-Luise Klietz, Anna Katharina Harren, Qiang Wei, Tobias Hirsch, Matthias M. Aitzetmueller
Summary: Breast implant illness (BII) remains poorly defined and controversial, with little scientific research available on its etiology, clinical manifestations, diagnostic criteria, or treatment. As one of the most popular cosmetic procedures, the issue of implant-related complications has been widely debated since the FDA approved the use of implants in 1962.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Maximilian Kueckelhaus, Nils Gebur, David Kampshoff, Mirkka Hiort, Charalampos Varnava, Kamran Harati, Tobias Hirsch, Philipp Wiebringhaus
Summary: The SCIP flap, a minimally invasive surgical technique widely used in Asia, has shown satisfactory outcomes in Caucasian patients as well. However, anatomical and physiological differences between Caucasian and Asian populations require modifications to increase the reliability of the procedure. More international outcome reports are needed to further promote the application of the SCIP flap worldwide.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Urology & Nephrology
Sammy Al-Benna
Summary: The study found that ACE2 gene expression in the human male urogenital tract is higher than in the lungs, making these tissues more susceptible to SARS-CoV-2 infection. This infection may interfere with male reproductive functions.
AFRICAN JOURNAL OF UROLOGY
(2021)
Letter
Surgery
Siling Yang, Marie-Luise Klietz, Tobias Hirsch, Philipp Wiebringhaus, Matthias M. Aitzetmuller
Summary: Although breast surgeries are common, there is a lack of focus on establishing a reliable method for measuring breast volume. While CT and MRI scans are already used in clinical practice, 3D scanning is a promising tool that can measure breast volume in an upright position. However, its reliability has not been extensively investigated.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Surgery
Siling Yang, Marie-Luise Klietz, Tobias Hirsch, Philipp Wiebringhaus, Matthias M. Aitzetmueller
Summary: Postoperative loss of breast volume is a significant factor in evaluating the outcome of breast reconstruction. The structural pattern of breast volume loss provides an important parameter for preoperative planning, reducing postoperative breast asymmetry and the need for reoperation. This study compares the volume change of three main breast reconstruction techniques: autologous flap-based, prosthesis-based, and autologous fat transplantation.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Critical Care Medicine
Toni Huw Mihailidis, Sammy Al-Benna
Summary: This study observes a positive trend in high-evidence publications, but the reporting of randomized controlled trials remains poor. It is recommended to adhere to standard reporting guidelines to improve the quality of reporting.
Article
Surgery
Anna K. Harren, Marie-L Klietz, Matthias M. Aitzetmueller, Florian Dittrich, Tobias Hirsch
Summary: With the increasing availability of the internet and cell phones, there is a growing demand for digitalized medical care among patients. A prospective study involving 405 patients was conducted to investigate their expectations and requirements of app-based mHealth applications. The results revealed that behavioral guidance after surgery, overview of personal findings, and contact with the treating physician were the most important factors.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Siling Yang, Xixi Lin, Maximilian Kueckelhaus, Tobias Hirsch, Marie-Luise Klietz, Matthias M. Aitzetmueller
Summary: Breast reconstruction research has been steadily developing in recent years, with a focus on improving surgical techniques, enhancing postoperative recovery, and ensuring oncological safety.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Matthias M. Aitzetmueller, Laura Raschke, Marie-Luise Klietz, Maximilian Kueckelhaus, Tobias Hirsch, Philipp Wiebringhaus, Kamran Harati
Summary: This study assessed the impact of postbariatric body contouring procedures on patients' quality of life (QoL), finding that abdominoplasty is the most important procedure for QoL improvement, significantly enhancing patients' body image satisfaction and psychosocial metrics.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Medicine, General & Internal
Matthias Hamatschek, Henning Knors, Marie-Luise Klietz, Philipp Wiebringhaus, Matthias Aitzetmueller, Tobias Hirsch, Maximilian Kueckelhaus
Summary: This study aims to provide further insights into the characteristics of lipedema patients and establish a baseline prior to surgical treatment. The results show that lipedema patients experience severe symptoms and impaired functioning in daily life, with a high level of mental stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
M. M. Aitzetmueller, M. Kueckelhaus, T. Hirsch, S. Wellenbrock
Summary: Defects in the thoracic region can have various origins and treating them requires complex surgical procedures that involve interdisciplinary cooperation. Factors such as the size of the defect, previous medical history and surgeries, and blood flow are crucial in determining the appropriate surgical technique. The goal is not just to close the defect, but also to ensure proper revascularization of the damaged tissue. Various reconstruction options, including split-skin coverage, local and perforator-based flaps, and free microvascular tissue transfers, should be considered. Utilizing the full range of plastic surgical and especially microsurgical expertise is essential for achieving optimal outcomes.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2022)
Review
Medicine, General & Internal
Matthias M. Aitzetmueller, Marie-Luise Klietz, Alexander F. Dermietzel, Tobias Hirsch, Maximilian Kueckelhaus
Summary: Robotic-assisted surgeries have become routine procedures in many surgical fields in recent years, except in plastic surgery. This review provides an overview of the emerging technologies and potential of robotic assistance in the field of plastic surgery, based on a comprehensive analysis of literature from various research databases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
R. Botha, J. H. Cardoso, A. Lombard, V. Vermeulen, T. R. Forgan, S. Al-Benna, K. M. Chu
Summary: This study investigated the impact of COVID-19 on surgical training and research in South Africa. The results showed a decrease in the quality of surgical training and skills acquisition among surgical trainees during the pandemic, as well as a negative impact on their mental well-being.
SOUTH AFRICAN JOURNAL OF SURGERY
(2022)
