Article
Materials Science, Multidisciplinary
Sixiang Wang, Yan Gao, Lili Dong, Peixing Chen, Wanqian Liu, Li Yang
Summary: This study developed a novel drug delivery system targeting cartilage, which includes an ROS scavenger and an inflammatory-responsive nanocarrier. It was demonstrated that the nanocarrier exhibited excellent cartilage-targeting effects and ROS scavenging capacities, effectively suppressing angiogenesis and cartilage degradation, providing a promising therapeutic strategy for the treatment of OA and other inflammatory diseases characterized by oxidative stress and angiogenesis.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chen Dong, Xuehua Ma, Yi Huang, Yujie Zhang, Xiang Gao
Summary: This study demonstrates the synthesis of carbon dots nanozyme with excellent scavenging activity of reactive oxygen species (ROS) for anti-inflammatory therapy, indicating its potential in the treatment of inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Oncology
Jiatong Liu, Xiaoyue Han, Tingyue Zhang, Keyue Tian, Zhaoping Li, Feng Luo
Summary: Inflammation is a defensive response to harmful stimuli, but excessive inflammation is associated with various diseases. Reactive oxygen species (ROS) play a critical role as signaling molecules in modulating physiological functions, but high levels of ROS can cause toxic effects and worsen inflammation, leading to inflammatory diseases. Therefore, developing biomaterials that scavenge ROS is important for restoring ROS balance, limiting inflammation, and protecting the host.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marwa Ben-Khemis, Dan Liu, Coralie Pintard, Zhuoyao Song, Margarita Hurtado-Nedelec, Jean-Claude Marie, Jamel El-Benna, Pham My-Chan Dang
Summary: TNF alpha disrupts IL-10 signaling by inducing STAT3 dephosphorylation through a NOX2-ROS-Lyn-SHP1 axis in human monocytes, leading to prolonged inflammation. These findings explain the poor efficacy of IL-10 therapy in patients with inflammatory diseases and suggest that anti-TNF alpha agents and SHP1/2 inhibitors could improve the therapeutic use of IL-10.
Article
Biophysics
Xiaofei Wang, Hongxiu Wei, Yangcen Ou, Zhen Li, Feng Luo, Hong Tan, Jiehua Li
Summary: The development of an inflammation modulating PP mesh for pelvic floor repair is an urgent clinical need. In this study, a PP composite mesh was successfully prepared that can scavenge ROS and inhibit inflammation. The composite mesh exhibited excellent ROS scavenging and anti-inflammatory properties in vitro and in vivo. Thus, this PP mesh with ROS scavenging and anti-inflammatory properties provides a promising approach for mitigating FBR.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Alice Donato, Federico Fontana, Rina Venerando, Antonino Di Stefano, Paola Brun
Summary: The study aimed to evaluate the anti-inflammatory and antioxidant effects of lactose-modified hyaluronic acids on smoking-related diseases. The results showed that HYLACH with a lactosylation percentage of 10-40% were the best ligands, capable of attenuating macrophage-mediated inflammation, inhibiting MMP expression, and exhibiting antioxidative effects.
Article
Biotechnology & Applied Microbiology
Bosong Zhang, Yufang Zhao, Kai Guo, Hui Tian, Cao Wang, Ruiqi Wang, Yue Chen, Xiongbiao Chen, Hongxia Zheng, Bingxin Gao, Jieyi Shen, Weiming Tian
Summary: Prevention and early intervention are crucial in treating Alzheimer's disease (AD). This study investigates the use of nanoparticles composed of resveratrol and oligomeric proanthocyanidin grafted with hyaluronic acid to address the issue of ROS accumulation in early AD. The results demonstrate that these nanoparticles are effective in scavenging ROS, reducing brain inflammation, and improving cognitive function in AD mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zunjing Liu, Zihao Liu, Yi Shan, Chen Xu, Bingran Yu, Fu-Jian Xu
Summary: This study introduced a ROS scavenger and a targeted peptide to construct a nucleic acid delivery system for treating atherosclerosis. The system effectively reduced inflammation and reactive oxygen species production, alleviating the progression of atherosclerosis, and displayed good biosafety.
Article
Microbiology
Paola Brun, Anna Piovan, Rosy Caniato, Vanessa Dalla Costa, Anthony Pauletto, Raffaella Filippini
Summary: The study demonstrated that fractionated extracts obtained from E. gracilis can reduce LPS-induced intestinal inflammation, with pheophytin a and b and canthaxanthin increasing intracellular reducing potential and reducing the generation of oxidative stress and lipid peroxidation induced by LPS.
Article
Biochemistry & Molecular Biology
Mina Jafari, Vishnu Sriram, Gurdat Premnauth, Edward Merino, Joo-Youp Lee
Summary: ROS plays a crucial role in intracellular signaling and is elevated in tumor microenvironment. This study developed a series of novel ROS-responsive prodrugs of doxorubicin, among which the OH-mOX-Dox prodrug showed potent anti-proliferation effects against breast cancer cells with minimal toxicity towards normal cells. Enhanced cytotoxicity of OH-mOX-Dox prodrug was observed at elevated ROS levels, especially when co-incubated with BSO. Clonogenic assay validated the increased efficacy of OH-mOX-Dox prodrug against breast cancer cells with enhanced intracellular ROS levels after X-ray irradiation.
BIOORGANIC CHEMISTRY
(2022)
Review
Oncology
Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo, Yong Xu, Wei Qian
Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Article
Biochemistry & Molecular Biology
Meng-Jin Lin, Ping Lin, Kuo-Ching Wen, Hsiu-Mei Chiang, Mei-Chun Lu
Summary: This study evaluated the antioxidant and anti-inflammatory activities of Ficus awkeotsang Makino extract (FAE) on fibroblasts and mouse models. The results showed that FAE exhibited strong antioxidant and anti-inflammatory effects, and could inhibit UVB-induced inflammation. These findings highlight the potential of FAE as a versatile adjuvant against free radical damage in pharmaceutical applications.
Review
Environmental Sciences
Madhuri Grover, Tapan Behl, Simona Bungau, Lotfi Aleya
Summary: This study focuses on investigating the anti-inflammatory properties of vetiver, revealing that its plant extract can stimulate the antioxidant enzyme system network, reduce oxidative stress, exhibit antimicrobial activity, and have a CNS depressant effect, showing potential benefits in treating inflammation-related disorders.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Gangqiang Yang, Xiaoliang Mi, Yunxiao Wang, Shuang Li, Liping Yu, Xinru Huang, Shuai Tan, Hui Yu
Summary: Ginsenoside derivatives with Michael acceptor fused into the aglycone A-ring were synthesized and evaluated for their anti-inflammatory activity. The 4-nitrobenzylidene derivative of PPD (2a) showed the most effective inhibition of proinflammatory cytokine release. Further studies revealed that 2a downregulated iNOS protein expression and cytokine release through inhibition of the MAPK and NF-KB signaling pathways. Additionally, 2a almost completely inhibited LPS-induced production of mtROS and NLRP3 upregulation. These findings suggest that the fusion of Michael acceptors into ginsenosides greatly enhances their anti-inflammatory activity, with 2a showing significant anti-inflammatory effects by inhibiting mtROS-mediated activation of the NLRP3 pathway.
BIOORGANIC CHEMISTRY
(2023)
Article
Genetics & Heredity
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro, Sergio Daga, Francesca Fava, Elisa Benetti, Sara Amitrano, Mirella Bruttini, Maria Palmieril, Susanna Croci, Mirjam Lista, Giada Beligni, Floriana Valentino, Ilaria Meloni, Marco Tanfoni, Francesca Minnai, Francesca Colombo, Enrico Cabri, Maddalena Fratelli, Chiara Gabbi, Stefania Mantovani, Elisa Frullanti, Marco Gori, Francis P. Crawley, Guillaume Butler-Laporte, Brent Richards, Hugo Zeberg, Miklos Lipcsey, Michael Hultstrom, Kerstin U. Ludwig, Eva C. Schulte, Erola Pairo-Castineira, John Kenneth Baillie, Axel Schmidt, Robert Frithiof, Francesca Mari, Alessandra Renieri, Simone Furini
Summary: The study developed a machine-learning model using common and rare exonic variants to predict COVID-19 severity. By selecting key Boolean features and combining them into an Integrated PolyGenic Score, the model offers insights into the genetic contribution to disease severity. A quarter of the selected genes are sex-specific, and pathway analysis highlighted the multi-organ nature of COVID-19 severity. This model could potentially aid in diagnostics, therapeutics, and disease management at the bedside.
Article
Oncology
Sara Pizzamiglio, Giulia Cosentino, Chiara M. Ciniselli, Loris De Cecco, Alessandra Cataldo, Ilaria Plantamura, Tiziana Triulzi, Sarra El-abed, Yingbo Wang, Mohammed Bajji, Paolo Nuciforo, Jens Huober, Susan L. Ellard, David L. Rimm, Andrea Gombos, Maria Grazia Daidone, Paolo Verderio, Elda Tagliabue, Serena Di Cosimo, Marilena V. Iorio
Summary: The study evaluated the predictive and prognostic value of basal primary tumor miRNA expression profile in trastuzumab treatment and identified miRNA signatures associated with clinical outcomes. These miRNA markers have the potential to be a useful tool in identifying patients with differential responses to trastuzumab-based neoadjuvant therapy.
Article
Oncology
Elisabetta Schiavello, Veronica Biassoni, Giovanna Gattuso, Marta Podda, Stefano Chiaravalli, Francesco Barretta, Manila Antonelli, Loris De Cecco, Emilia Pecori, Lorenza Gandola, Maura Massimino
Summary: This is a small series of homogeneously-treated DMG patients with H3K27M mutation. The treatment approach is similar to DIPG and the results obtained are comparable with those of DIPG patients. Therefore, these DMG patients should be included in registries and protocols of DIPG.
Article
Oncology
Francesca Minnai, Sara Noci, Marco Chierici, Chiara Elisabetta Cotroneo, Barbara Bartolini, Matteo Incarbone, Davide Tosi, Giovanni Mattioni, Giuseppe Jurman, Tommaso A. Dragani, Francesca Colombo
Summary: Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral lung tissue. Gene expression data from noninvolved lung tissue of 483 lung adenocarcinoma patients were analyzed, and a signature of transcripts associated with lung adenocarcinoma outcome was identified. Pathway analysis indicated enrichment of ECM components. Genetic predisposition to lung adenocarcinoma outcome was found to be present in patients' noninvolved lung tissue.
Article
Oncology
Giancarla Bernardo, Valentino Le Noci, Emerenziana Ottaviano, Loris De Cecco, Chiara Camisaschi, Simone Guglielmetti, Martina Di Modica, Giorgio Gargari, Francesca Bianchi, Serena Indino, Patrizia Sartori, Elisa Borghi, Michele Sommariva, Elda Tagliabue, Tiziana Triulzi, Lucia Sfondrini
Summary: This study highlights the significant influence of mammary tumor microbiota on local immune status and the relevance of its treatment with antibiotics, in combination with breast cancer therapies.
Review
Biology
Amelia Barcellini, Alexandra Charalampopoulou, Loris De Cecco, Andrei Fodor, Emanuela Rabaiotti, Giorgio Candotti, Simona Secondino, Angelica Facoetti, Laura Deborah Locati, Sandro Pignata, Ester Orlandi, Giorgia Mangili
Summary: Radiotherapy is increasingly being used in combination with surgery, chemotherapy, and novel drugs to treat ovarian cancer. This review aims to summarize the current understanding of the radiosensitivity and radioresistance of ovarian cancer, which is the deadliest gynecological cancer worldwide. Understanding the mechanisms of radiosensitivity and identifying potential biomarkers of radioresistance could be crucial in guiding clinical decision-making, considering the high rate of recurrence in and out of the radiotherapy fields, especially in the era of personalized oncology.
Article
Oncology
Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosue Scognamiglio, Michele Del Sesto, Germana Tognon, Daniela Califano, Clorinda Schettino, Paolo Chiodini, Francesco Perrone, Delia Mezzanzanica, Sandro Pignata, Antonella Tomassetti
Summary: The membrane expression of EGFR can serve as a prognostic biomarker in ovarian cancer patients and is associated with the efficacy of anti-angiogenic therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Correction
Oncology
Chiara Fallerini, Sergio Daga, Elisa Benetti, Nicola Picchiotti, Kristina Zguro, Francesca Catapano, Virginia Baroni, Simone Lanini, Alessandro Bucalossi, Giuseppe Marotta, Francesca Colombo, Margherita Baldassarri, Francesca Fava, Giada Beligni, Laura Di Sarno, Diana Alaverdian, Maria Palmieri, Susanna Croci, Andrea M. M. Isidori, Simone Furini, Elisa Frullanti, Alessandra GEN-COVID Multictr Study, Alessandra Renieri, Francesca Mari
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Francesca Minnai, Sara Noci, Nunzia Mangano, Loris De Cecco, Cristina Meazza, Monica Terenziani, Maura Massimino, Francesca Colombo
Summary: In this exome-wide association study, gene sets significantly associated with neutropenia and hepatotoxicity induced by methotrexate were identified in pediatric osteosarcoma patients. However, further validation and functional characterization of these associations are needed in larger series, emphasizing the importance of investigating variants along the whole genome to identify potential pharmacogenes.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Tommaso A. Dragani, Thomas Muley, Marc A. Schneider, Sonja Kobinger, Martin Eichhorn, Hauke Winter, Hans Hoffmann, Mark Kriegsmann, Sara Noci, Matteo Incarbone, Davide Tosi, Sara Franzi, Francesca Colombo
Summary: This study examined the relationships between smoking habit, clinical stage, and sex with age at diagnosis of lung adenocarcinoma. The results showed that smoking, advanced stage, and female sex were associated with younger age at diagnosis. This study provides new insights into the clinical variables influencing age at diagnosis and opens up possibilities for further research on the genetic and molecular mechanisms responsible for these associations.
Review
Biochemistry & Molecular Biology
Roberta Ottria, Ornella Xynomilakis, Silvana Casati, Ezio Abbiati, Giovanni Maconi, Pierangela Ciuffreda
Summary: This article provides a summary of the effects of P. lentiscus var. Chia gum on inflammatory bowel disease, discussing its chemical composition and pharmacological action. The review offers guidance for future research and highlights the possible bioactive components of mastic gum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Francesca Spyrakis, Tommaso A. Dragani
Summary: The proposal by the European Chemicals Agency to ban over 12,000 per- and polyfluoroalkyl substances has sparked a debate about the potential consequences for the economy, industry, and the environment. A blanket ban may lead to unsafe alternative materials and unintended environmental consequences.
Letter
Surgery
Armando G. Licata, Chiara M. Ciniselli, Luca Sorrentino, Arianna Micali, Maria Grazia Daidone, Marcello Guaglio, Manuela Gariboldi, Paolo Verderio, Loris De Cecco, Maurizio Cosimelli
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Oncology
Giulia Cosentino, Sara Pizzamiglio, Chiara M. Ciniselli, Loris De Cecco, Alessandra Cataldo, Ilaria Plantamura, Tiziana Triulzi, Sarra El-Abed, Yingbo Wang, Mohammed Bajji, Paolo Nuciforo, Jens Huober, Susan L. Ellard, David L. Rimm, Andrea Gombos, Mariagrazia Daidone, Paolo Verderio, Elda Tagliabue, Serena Di Cosimo, Marilena V. Iorio
