期刊
REDOX BIOLOGY
卷 2, 期 -, 页码 1008-1015出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2014.08.006
关键词
Immp2l; Cytochrome c1; GPD2; Complex III; Mitochondrial respiration
资金
- National Institutes of Health [R01HD058058]
Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome cl (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2). Immp2l mutant mice show infertility and early signs of aging. It is unclear whether mitochondrial respiratory deficiency underlies this phenotype. Here we show that the intermediate forms of GPD2 and CYC1 have normal expression levels and enzymatic function in Immp2l mutants. Mitochondrial respiration is not diminished in isolated mitochondria and cells from mutant mice. Our data suggest that respiratory deficiency is not the cause of the observed Immp2l mutant phenotypes. (C) 2014 The Authors. Published by Elsevier B.V.
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