Article
Multidisciplinary Sciences
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Summary: The study shows that an oxolinic acid-derivative RyR1 inhibitor can effectively prevent and treat various malignant hyperthermia (MH) and heat stroke mouse models.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Daniela Baracaldo-Santamaria, Sara Sofia Avendano-Lopez, Daniel Felipe Ariza-Salamanca, Mateo Rodriguez-Giraldo, Carlos A. Calderon-Ospina, Rodrigo E. Gonzalez-Reyes, Mauricio O. Nava-Mesa
Summary: Alzheimer's disease is a chronic neurodegenerative disease that causes progressive dementia in older adults. It is characterized by memory loss and cognitive impairment due to dysfunction in cholinergic pathways and neurotoxicity mediated by N-methyl-D-aspartate (NMDA). The presence of intracellular neurofibrillary tangles, extracellular amyloid-beta (A beta) plaques, and selective neurodegeneration are the pathological hallmarks of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Beatrix Dienes, Tamas Bazso, Laszlo Szabo, Laszlo Csernoch
Summary: Since the discovery of Piezo1 channels, studies have investigated their role in various physiological and pathological processes in different organs. However, our understanding of their effects on the musculoskeletal system is still limited. This review summarizes the current knowledge regarding their impact on skeletal muscles, bones, joints and cartilage, tendons and ligaments, and intervertebral discs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen
Summary: The study showed that pharmacological activation of SERCA can mitigate sarcopenia phenotype in aging mice, reversing reductions in muscle mass and force generation, and preventing an increase in mitochondrial ROS production. These effects are mediated in part by enhanced cellular energetics through activation of PGC1-alpha, UCP1, HSF1, and APMK, as well as increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Hussein Abuammar, Arindam Bhattacharjee, Zsofia Simon-Vecsei, Andras Blastyak, Gabor Csordas, Tibor Pali, Gabor Juhasz
Summary: Autophagy, the cellular self-degradation process, is closely linked to lysosomal degradative function, with ion channels and pumps playing a crucial regulatory role. TRPML1, as an example, regulates autophagic progression by modulating calcium signaling and activation of mTORC1. Additionally, disruption of ER calcium supply to lysosomes can severely impair lysosomal function.
Article
Biochemistry & Molecular Biology
Monika Sztretye, Zoltan Singlar, Nyamkhuu Ganbat, Dana Al-Gaadi, Kitti Szabo, Zoltan Marton Kohler, Laszlo Dux, Aniko Keller-Pinter, Laszlo Csernoch, Peter Szentesi
Summary: The remodelling of the extracellular matrix plays a crucial role in skeletal muscle development and regeneration. The decreased expression of Syndecan-4 leads to reduced muscle performance and altered calcium homeostasis in mice. These effects are observed at both young and aged stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Summary: Endothelial cells sense shear stress through Piezo1 and activate ER Ca2+ entry and release via IP3R2. The involvement of sAC and IP3R2 in this process is crucial.
Article
Environmental Sciences
Margarida Lorigo, Carla Quintaneiro, Claudio J. Maia, Luiza Breitenfeld, Elisa Cairrao
Summary: Long-term exposure to the UV-filter OMC in personal care products may disrupt vascular homeostasis of pregnant women, potentially leading to pregnancy hypertensive disorders.
Article
Chemistry, Multidisciplinary
Ning Li, Chen Li, Boying Li, Chaoqun Li, Qi Zhao, Zhongming Huang, Yue Shu, Xiongwei Qu, Baiqi Wang, Shengliang Li, Chengfen Xing
Summary: In this study, biomimetic conjugated oligomeric nanoparticles were developed to modulate blood glucose homeostasis by activating calcium channels with near-infrared laser. The results showed that these nanoparticles effectively regulated glucose metabolism, holding promise for diabetes treatment.
Article
Virology
P. Sanjai Kumar, Anukrishna Radhakrishnan, Tathagata Mukherjee, Somlata Khamaru, Soma Chattopadhyay, Subhasis Chattopadhyay
Summary: This review highlights the importance of Ca2+ in diverse viruses and the role of Ca2+-conducting TRP channels in viral pathophysiology. TRP channels play a crucial role in various viral life-cycle events and may act as a target for antiviral therapeutics.
Article
Microbiology
Congcong Sun, Xingyue Li, Yuanwei Zhang, Ling Lu
Summary: The study identified a crucial role of VmaC gene in Aspergillus fumigatus, involving in maintaining cellular homeostasis and cell wall integration pathway regulation. Compared to model yeasts, VmaC in A. fumigatus is essential for hyphal growth and conidiation.
Article
Multidisciplinary Sciences
Perrine Delers, Delphine Sapaly, Badih Salman, Stephan De Waard, Michel De Waard, Suzie Lefebvre
Summary: Deficiency of SMN protein causes spinal muscular atrophy (SMA) and flunarizine has been shown to improve NMJs in SMA model mice. This study further uncovers that flunarizine promotes AChR clustering in a cell-autonomous and dose-dependent manner. It also affects the expression and interaction of key proteins involved in the NMJ biology, such as LRP4, integrin-beta-1, and MuSK.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jaqueline Pereira Moura Soares, Diego Assis Goncalves, Ricardo Xisto de Sousa, Margareth Gori Mouro, Elisa M. S. Higa, Leticia Paulino Sperandio, Carolina Moraes Vitoriano, Elisa Bachir Santa Rosa, Fernanda Oliveira dos Santos, Gustavo Nery de Queiroz, Roberta Sessa Stilhano Yamaguchi, Gustavo Pereira, Marcelo Yudi Icimoto, Fabiana Henriques Machado de Melo
Summary: Cutaneous melanoma is the most aggressive type of skin cancer, and it progresses through different stages. Reactive oxygen species modulate oncogenic signaling pathways in all stages of melanoma development. The altered concentration of tetrahydrobiopterin disrupts cellular redox homeostasis and contributes to melanoma progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ludmila Zylinska, Malwina Lisek, Feng Guo, Tomasz Boczek
Summary: Vitamin C is important for antioxidant defense and its deficiency in the nervous tissue can lead to disruptions in neurotransmission and brain function. Calcium plays a crucial role in neuronal processes and Vitamin C has a unique role in regulating calcium-involved pathways in the brain.
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Nitric oxide (NO) is a small molecule that has a significant impact on various biological activities. It has been linked to cancer-related processes and has the potential to be used as an anti-cancer agent. In this study, NO-releasing materials were developed using modified sodium alginate hydrogel, which showed compatibility with cell growth. The release of NO from the hydrogel exhibited distinct kinetic features.
Article
Multidisciplinary Sciences
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Article
Physiology
Yunfei Huang, Yubo Fan, Michele Salanova, Xiao Yang, Lianwen Sun, Dieter Blottner
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Britt Schoenrock, Vanja Zander, Sebastian Dern, Ulrich Limper, Edwin Mulder, Alar Veraksits, Ragnar Viir, Andreas Kramer, Maria J. Stokes, Michele Salanova, Aleko Peipsi, Dieter Blottner
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Coralie Arc-Chagnaud, Guillaume Py, Theo Fovet, Remi Roumanille, Remi Demangel, Allan F. Pagano, Pierre Delobel, Stephane Blanc, Bernard J. Jasmin, Dieter Blottner, Michele Salanova, Mari-Carmen Gomez-Cabrera, Jose Vina, Thomas Brioche, Angele Chopard
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Physiology
Dieter Blottner, Maria Hastermann, Robert Weber, Regina Lenz, Guido Gambara, Ulrich Limper, Joern Rittweger, Alessandra Bosutti, Hans Degens, Michele Salanova
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Dieter Blottner, Daniele Capitanio, Gabor Trautmann, Sandra Furlan, Guido Gambara, Manuela Moriggi, Katharina Block, Pietro Barbacini, Enrica Torretta, Guillaume Py, Angele Chopard, Imre Vida, Pompeo Volpe, Cecilia Gelfi, Michele Salanova
Summary: This study evaluated the efficacy of an antioxidant cocktail in preventing oxidative stress and promoting muscle development during bedrest-induced muscle atrophy. The treatment group showed prevention of redox homeostasis dysregulation, enhanced structural remodeling and myogenesis, and normalization of metabolic pathways, while exhibiting increased antioxidant defense response.
Article
Biochemistry & Molecular Biology
Paola Lorenzon, Sandra Furlan, Barbara Ravara, Alessandra Bosutti, Gabriele Massaria, Annalisa Bernareggi, Marina Sciancalepore, Gabor Trautmann, Katharina Block, Dieter Blottner, Paul F. Worley, Sandra Zampieri, Michele Salanova, Pompeo Volpe
Summary: The study demonstrates that Homer 2 plays a crucial role in skeletal muscle adaptation and plasticity, with specific effects on muscle fiber cross-sectional area and gene expression. Further investigation is needed to determine the impact of Homer 2 deficiency on neuromuscular junction remodeling.
Article
Biochemistry & Molecular Biology
Dieter Blottner, Gabor Trautmann, Sandra Furlan, Guido Gambara, Katharina Block, Martina Gutsmann, Lian-Wen Sun, Paul F. Worley, Luisa Gorza, Martina Scano, Paola Lorenzon, Imre Vida, Pompeo Volpe, Michele Salanova
Summary: The molecular mechanisms of skeletal muscle atrophy under extended periods of either disuse or microgravity are not yet fully understood. The transition of Homer isoforms may play a key role during neuromuscular junction (NMJ) imbalance/plasticity in space.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Paul E. Muckelt, Martin B. Warner, Tom Cheliotis-James, Rachel Muckelt, Maria Hastermann, Britt Schoenrock, David Martin, Robert MacGregor, Dieter Blottner, Maria Stokes
Summary: This study aimed to assess the reliability of two non-invasive tools for evaluating muscle health, with results showing good to excellent reliability in most aspects. Additionally, established MDC values were provided for several measurement points, supporting the work of both researchers and clinicians.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Pietro Barbacini, Dieter Blottner, Daniele Capitanio, Gabor Trautmann, Katharina Block, Enrica Torretta, Manuela Moriggi, Michele Salanova, Cecilia Gelfi
Summary: Physical inactivity or prolonged bed rest can lead to muscle deconditioning and increased cardiovascular disease risk. Nutritional interventions, such as an antioxidant cocktail, have been found to preserve lipemic and reactive oxidative and nitrosative stress (RONS) homeostasis. This study investigated the effects of an antioxidant cocktail on serum molecules in healthy male subjects enrolled in a 60-day bed rest protocol.
Article
Biochemistry & Molecular Biology
Martin Schubert, Andreas Pelz, Gabor Trautmann, Katharina Block, Sandra Furlan, Martina Gutsmann, Siegfried Kohler, Pompeo Volpe, Dieter Blottner, Andreas Meisel, Michele Salanova
Summary: Accelerated postsynaptic remodelling and disturbance of neuromuscular transmission are common features of autoimmune neurodegenerative diseases. In an experimentally induced autoimmune model of Myasthenia Gravis (EAMG) in mice, the expression, crosslinking activity, and subcellular localization of Homer protein isoforms were studied in hind limb muscles and correlated with motor end plate integrity. The results showed that there were significant changes in the crosslinking activity and expression of Homer isoforms in different types of muscles in EAMG mice, which were associated with the integrity of neuromuscular junction and muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dieter Blottner, Manuela Moriggi, Gabor Trautmann, Maria Hastermann, Daniele Capitanio, Enrica Torretta, Katharina Block, Joern Rittweger, Ulrich Limper, Cecilia Gelfi, Michele Salanova
Summary: This study analyzed the muscle adaptation to spaceflight in male International Space Station (ISS) astronauts. The results showed that long-duration mission (LDM) astronauts who performed routine inflight exercise had moderate myofiber atrophy compared to short-duration mission (SDM) astronauts, suggesting the importance of exercise in maintaining muscle health during spaceflight. These findings contribute to the understanding of skeletal muscle adaptation and provide valuable information for future deep space exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Deeksha Malhan, Muege Yalcin, Britt Schoenrock, Dieter Blottner, Angela Relogio
Summary: This study investigated the functional consequences of disruptions to the circadian clock on skeletal muscle. The findings suggest that spaceflight and aging result in similar gene expression changes associated with muscle atrophy. Additionally, external factors such as exercise or fasting may compensate for the circadian disruption observed during spaceflights. Therefore, maintaining circadian functioning is crucial for preventing unphysiological alterations and musculoskeletal atrophy in astronauts.
Article
Sport Sciences
Alireza Basti, Muege Yalcin, David Herms, Janina Hesse, Ouda Aboumanify, Yin Li, Zita Aretz, Josefin Garmshausen, Rukeia El-Athman, Maria Hastermann, Dieter Blottner, Angela Relogio
Summary: This study investigated daily fluctuations in molecular and physiological features in human peripheral cells and their correlation with exercise performance. The research found that core-clock genes exhibit daily fluctuations and exercise performance peaks in the late afternoon. Muscle tone variation was also found to correlate with exercise performance, and molecular daily profiles were linked to daily variation in performance.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Helena C. Kenny, Floriane Rudwill, Laura Breen, Michele Salanova, Dieter Blottner, Tim Heise, Martina Heer, Stephane Blanc, Donal J. O'Gorman