Article
Peripheral Vascular Disease
Kelsey McLaughlin, John W. Snelgrove, Melanie C. Audette, Atif Syed, Sebastian R. Hobson, Rory C. Windrim, Nir Melamed, Sergio Carmona, John C. Kingdom
Summary: This study evaluated the association between maternal PlGF levels and pregnancy outcomes in high-risk pregnancies, finding a strong correlation between low PlGF levels and adverse outcomes such as preterm birth, early-onset preeclampsia, and stillbirth.
Article
Multidisciplinary Sciences
Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Summary: This study compared the expression of anti-angiogenic sFlt1 and pro-angiogenic PlGF in placenta and maternal blood in GDM, GDM-PE, CTRL, and PE cases. The results showed higher sFlt1/PlGF values in GDM-PE maternal blood, decreased PlGF gene expression in GDM, PE, and GDM-PE placentae, and increased PlGF protein levels in GDM and GDM-PE placentae. Additionally, sFlt1 gene expression was higher in PE placentae, while sFlt1 protein expression was lower in GDM-PE placentae. These findings suggest a potential link between sFlt1 overproduction and PE onset in GDM pregnancies.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Lingyan Zhu, Jieqi Qian, Yinan Jiang, Tianlun Yang, Qiong Duan, Xiangwei Xiao
Summary: The study found attenuated PlGF upregulation in a mouse DFD model and demonstrated that PlGF injection improved angiogenesis and recovery of DFD, which was largely attenuated by macrophage-specific depletion of VEGFR1. This indicates that reduced PlGF compromises angiogenesis in DFD partially through macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Peripheral Vascular Disease
Marlene Rezk, Linda Grasegger, Esma Hamzic, Sabine Enengl, Reinhard Altmann, Patrick Stelzl, Peter Oppelt, Barbara Arbeithuber
Summary: This study evaluated the effect of maternal age on sFlt-1/PlGF ratios and found that the change in maternal age can influence the diagnostic accuracy of sFlt-1/PlGF ratios for preeclampsia. Therefore, more accurate cutoff values for sFlt-1/PlGF should be determined based on maternal and gestational age.
JOURNAL OF HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Sama Hussein, Weina Ju, Stephanie Pizzella, Michael Flory, Chu Chu, Yong Wang, Nanbert Zhong
Summary: The study found that the expression of sFLT-1 and PlGF was reduced in preterm birth cases, while the sFLT-1/PlGF ratio was increased in EVs-EXs, indicating a potential biomarker for predicting preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tess Cruickshank, Teresa M. MacDonald, Susan P. Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: The study found that plasma GDF-15 levels were significantly increased in women more likely to develop preeclampsia or diagnosed with the condition. This suggests that GDF-15 may serve as a clinical biomarker and improve the sensitivity of the sFlt-1/PlGF ratio.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Hedia Zitouni, Vera Chayeb, Marwa Ben Ali Gannoun, Nozha Raguema, Sameh Bendhaher, Ines Zouari, Hassen Ben Abdennebi, Jean Guibourdenche, Touhami Mahjoub, Kamel Gaddour, Wassim Y. Almawi
Summary: This study investigated the association of ACE insertion/deletion (I/D) polymorphism with preeclampsia (PE) in Tunisian women. ACE I/D genotyping was performed and no significant difference in alleles and genotypes was observed between women with PE and control women. However, a significant difference in the frequency of the I/I genotype was seen between the two groups, with carriers of the I/I genotype having higher infant birth weights. The study also found a dose-dependent relationship between ACE I/D genotypes and VEGF and PlGF plasma levels. Furthermore, a positive correlation between PAC and PIGF was found. These findings suggest a potential role for ACE I/D polymorphism in the pathogenesis of PE and highlight the relationship between PAC and PlGF.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang
Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Clinical Neurology
Jason D. Hinman, Fanny Elahi, Davis Chong, Hannah Radabaugh, Adam Ferguson, Pauline Maillard, Jeffrey F. Thompson, Gary A. Rosenberg, Abhay Sagare, Abhay Moghekar, Hanzhang Lu, Tiffany Lee, Donna Wilcock, Claudia L. Satizabal, Russell Tracy, Sudha Seshadri, Kristin Schwab, Karl Helmer, Herpreet Singh, Pia Kivisakk, Steve Greenberg, Charlie DeCarli, Joel Kramer
Summary: This study found that plasma PlGF levels are associated with cognitive impairment and white matter injury, and can serve as a stable and reliable diagnostic biomarker.
ALZHEIMERS & DEMENTIA
(2023)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Medicine, General & Internal
Mei Liu, Rui-Bo Wang, Jian-Hong Xing, Ying-Xue Tang
Summary: The addition of Corin to sFlt-1, PLGF, and sFlt-1/PLGF can improve the predictive ability of each marker for pre-eclampsia risk. Corin in combination with sFlt-1/PLGF can be used as ideal markers to identify pregnant women at risk of developing pre-eclampsia, aiding in risk stratification and treatment management.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)