Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Oncology
Arianis Tatiana Ramirez, Gloria Ines Sanchez, Belinda Nedjai, Maria Cecilia Agudelo, Adam R. Brentnall, Kate Cuschieri, Kelly Melisa Castaneda, Jack Cuzick, Attila T. Lorincz
Summary: The study compared the effectiveness of S5 methylation test with HPV16/18 genotyping and cytology for detecting CIN2+ and CIN3+ in hrHPV+ women, showing that the S5 methylation test is more accurate in this population.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Anna Peguero, Ignacio Herraiz, Alfredo Perales, Juan Carlos Melchor, Inigo Melchor, Beatriz Marcos, Cecilia Villalain, Raigam Martinez-Portilla, Edurne Mazarico, Eva Meler, Sandra Hernandez, Isabel Matas, Maria Del Rio, Alberto Galindo, Francesc Figueras
Summary: The study aimed to determine whether using an algorithm based on maternal levels of placental growth factor in women with late preterm preeclampsia to evaluate the best time for delivery reduced the progression to preeclampsia with severe features without increasing adverse perinatal outcomes. The use of this algorithm resulted in a lower rate of progression to preeclampsia with severe features and reduced maternal complications without worsening neonatal outcomes. This suggests a potential benefit for using this algorithm in making decisions about the timing of delivery for women with late preterm preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Robin Tuytten, Argyro Syngelaki, Gregoire Thomas, Ana Panigassi, Leslie W. Brown, Paloma Ortea, Kypros H. Nicolaides
Summary: This study aimed to verify metabolite biomarkers as preterm preeclampsia predictors early in pregnancy in all women and across body mass index groups. The results showed that certain metabolites and ratios of amino acids were associated with preterm preeclampsia risk, but their predictive performance varied according to body mass index classification.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Peripheral Vascular Disease
Maged M. Costantine, Baha Sibai, Allan T. Bombard, Mark Sarno, Holly West, David M. Haas, Alan T. Tita, Michael J. Paidas, Erin A. S. Clark, Kim Boggess, Chad Grotegut, William Grobman, Emily J. Su, Irina Burd, George Saade, Martin R. Chavez, Michael J. Paglia, Audrey Merriam, Carlos Torres, Mounira Habli, Georges Macones, Tony Wen, James Bofill, Anna Palatnik, Rodney K. Edwards, Sina Haeri, Pankaj Oberoi, Amin Mazloom, Matthew Cooper, Steven Lockton, Gary D. Hankins
Summary: This study validates a novel multianalyte assay that is associated with the time to develop preeclampsia. The assay has moderate sensitivity and negative likelihood ratio but high negative predictive value when used as an aid to rule out preeclampsia within 7 days of enrollment.
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Manisha Kumar, Kirti Balyan, Ekta Debnath, Shivangi Shankar, Aryahi Apte, Shreeja Jha
Summary: This study evaluated the role of angiogenic biomarkers in predicting severe adverse materno-fetal outcomes among women at high risk of preeclampsia. It found that an increased sFlt-1/PlGF ratio was a good predictive marker, especially for those who developed complications before 34 weeks.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Manisha Kumar, Kirti Balyan, Ekta Debnath, Ben Himtsoe, Surbhi Sapna, Arunav Kumar
Summary: The study validates the predictive value of sFlt-1/PlGF ratio for risk stratification in high-risk pregnant women and suggests that testing at 28-30 weeks may be the optimal time for prediction of preeclampsia.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Review
Obstetrics & Gynecology
Sean Lim, Wentao Li, Jessica Kemper, Andrew Nguyen, Ben Willem Mol, Maya Reddy
Summary: The study systematically reviewed the performance of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in predicting adverse outcomes in women with preeclampsia. PlGF and the sFlt-1/PlGF ratio showed prognostic promise for adverse outcomes in preeclampsia, but study heterogeneity limits their clinical utility.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jelena Munjas, Miron Sopic, Aleksandra Stefanovic, Rok Kosir, Ana Ninic, Ivana Joksic, Tamara Antonic, Vesna Spasojevic-Kalimanovska, Ursula Prosenc Zmrzljak
Summary: Preeclampsia is a significant cause of maternal and neonatal morbidity and mortality worldwide, with abnormalities in lncRNAs and miRNAs in the placenta being associated with its pathophysiology. Currently, there is a lack of clinically available predictive biomarkers for Preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Kelsey McLaughlin, John W. Snelgrove, Melanie C. Audette, Atif Syed, Sebastian R. Hobson, Rory C. Windrim, Nir Melamed, Sergio Carmona, John C. Kingdom
Summary: This study evaluated the association between maternal PlGF levels and pregnancy outcomes in high-risk pregnancies, finding a strong correlation between low PlGF levels and adverse outcomes such as preterm birth, early-onset preeclampsia, and stillbirth.
Article
Oncology
Maria Fuglsang Jensen, Line Bjerregaard Stick, Morten Hoyer, Camilla Jensenius Skovhus Kronborg, Ebbe Laugaard Lorenzen, Hanna Rahbek Mortensen, Petra Witt Nystrom, Stine Elleberg Petersen, Pia Randers, Linh My Hoang Thai, Esben Svitzer Yates, Birgitte Vrou Offersen
Summary: The study presented proton plans and adaptation strategy for the first 43 breast cancer patients treated with protons in Denmark, demonstrating robustness towards breathing motion, setup- and range uncertainties. Anatomical evaluations were used to define treatment tolerances for anatomical changes, ensuring low mean heart dose and meeting planning criteria for most patients. Plan adaptation was performed for the majority of patients to address anatomical changes.
Article
Gastroenterology & Hepatology
Susanne Haas, Anette Hojer Mikkelsen, Camilla Jensenius Skovhus Kronborg, Birthe T. Oggesen, Pia F. Moller, Janne Fassov, Nina Abild Frederiksen, Marianne Krogsgaard, Charlotte Graugaard-Jensen, Lise Venzel, Peter Christensen, Katrine Jossing Emmertsen
Summary: This study examines the extent of late treatment-related sequelae in colorectal cancer survivors and provides evidence-based management strategies, aiming to facilitate identification and treatment of these conditions. Results show common symptoms and provide recommendations and strategies for their management.
COLORECTAL DISEASE
(2023)
Article
Obstetrics & Gynecology
Peter von Dadelszen, Argyro Syngelaki, Alan Wright, Ranjit Akolekar, Laura A. Magee, David Wright, Kypros H. Nicolaides
Summary: The Fetal Medicine Foundation 36-week competing-risk model can provide personalized guidance to women about the probable timing of their delivery and their risk of preeclampsia. Women in higher-risk categories are more likely to give birth earlier and through medically indicated delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Alan Wright, Peter von Dadelszen, Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Dave Wright, Kypros H. Nicolaides
Summary: This study examined the effect of self-declared race on serum placental growth factor (PlGF) and sFlt-1/PlGF ratio and its impact on the prediction of pre-eclampsia (PE). The results showed that compared to white women, black, South Asian, East Asian, and mixed race women had higher mean PlGF levels and lower sFlt-1/PlGF ratios.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Anna Cecilie Lef, Eva Serup-Hansen, Katrine Smedegaard Storm, Karen Lycke Wind, Camilla Kronborg, Karen-Lise Garm Spindler
Summary: The purpose of this study was to report patient-reported outcome (PRO) and National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) data for patients with squamous cell carcinoma of the anus (SCCA) treated with modern radiation therapy (RT) 1 year after treatment. The study found that functional mean scores were comparable to a normal population cohort, and there were minor improvements in global health status/quality of life, emotional functioning, insomnia, and appetite loss. Bowel and bladder symptoms showed minor improvements or stable conditions, while some symptoms worsened moderately.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Acoustics
A. Arechvo, A. Wright, A. Syngelaki, P. von Dadelszen, L. A. Magee, R. Akolekar, D. Wright, K. H. Nicolaides
Summary: This study aimed to investigate the relationship between the English Index of Multiple Deprivation (IMD) and the incidence of pre-eclampsia (PE), assess the distribution of IMD in a diverse cohort of pregnant women, and evaluate whether IMD improves the prediction of PE compared to a "history-only" competing-risks model. The results showed that the incidence of PE increased across IMD quintiles, and black women had a higher incidence of PE. However, IMD did not improve the prediction of PE compared to race and other maternal characteristics.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter von Dadelszen, Argyro Syngelaki, Ranjit Akolekar, Laura A. Magee, Kypros H. Nicolaides
Summary: This study aimed to compare the relative burdens of maternal and perinatal complications for preterm and term pre-eclampsia. A prospective observational cohort study was conducted in two English maternity units, including unselected women with singleton pregnancies who developed pre-eclampsia. The results showed that preterm pre-eclampsia was more likely to lead to adverse maternal and perinatal events; however, the majority of maternal complications and a significant proportion of perinatal complications still occurred in women with term pre-eclampsia. Therefore, efforts should be made to reduce the incidence of term pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Karen Lycke Wind, Karen-Lise Garm Spindler, Christina Maria Lutz, Lars Nyvang, Camilla Kronborg
Summary: This study aimed to estimate the dose of loco-regional recurrences (LRRs) in anal cancer using a point of origin-based method. It was found that the majority of LRRs were located within the high dose volume, indicating radioresistance as the main cause of recurrence in anal cancer.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
L. A. Magee, P. von Dadelszen
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter N. von Dadelszen, Jeffrey Bone, Akshdeep Sandhu, J. Mark N. Ansermino, Rahat Qureshi, Charfudin Sacoor, Esperanca Sevene, Jing Li, Marianne B. Vidler, Mrutyunjaya A. Bellad, Zulfiqar T. Bhutta, Dustin S. Dunsmuir, Shivaprasad A. Goudar, Ashalata Mallapur, Khatia A. Munguambe, Guy A. Dumont, Laura Magee
Summary: To inform digital health design by evaluating diagnostic test properties of antenatal blood pressure (BP) outputs and levels to identify women at risk of adverse outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Laura A. Magee, David Wright, Argyro Syngelaki, Peter von Dadelszen, Ranjit Akolekar, Alan Wright, Kypros H. Nicolaides
Summary: This study aimed to identify the optimal screening and timing of birth strategy for preventing term preeclampsia. The results showed that screening and delivering at 35-36 weeks had the highest efficacy in preventing term preeclampsia.
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Peter von Dadelszen, Kypros H. Nicolaides
Summary: This study aimed to investigate the role of serum placental growth factor (PlGF) at 19-23 weeks of gestation in risk identification. The results showed that clinical risk factor screening had limitations in detecting adverse outcomes, and PlGF testing alone did not reduce false positives. Therefore, alternative strategies are needed to improve risk identification.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Milly G. Wilson, Jeffrey N. Bone, Laura J. Slade, Hiten D. Mistry, Joel Singer, Sarah R. Crozier, Keith M. Godfrey, Janis Baird, Peter von Dadelszen, Laura A. Magee
Summary: This study examines the association of blood pressure thresholds and visit-to-visit blood pressure variability with adverse pregnancy outcomes. The findings suggest that higher blood pressure and blood pressure variability are associated with an increased risk of adverse outcomes during pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Niamh-Maire Mclennan, Robert Lindsay, Ponnusamy Saravanan, Nithya Sukumar, Sara L. White, Peter von Dadelszen, Christy Burden, Kathryn Hunt, Priya George, Jane E. Hirst, Katherine Lattey, Tara T. M. Lee, Helen R. Murphy, Eleanor M. Scott, Laura A. Magee, Rebecca M. Reynolds
Summary: This study aimed to evaluate the impact of implementing emergency care pathways on women with GDM during the COVID-19 pandemic. The findings showed that using HbA1c and fasting glucose can identify a higher-risk population of GDM, but it has minimal impact on pregnancy outcomes. Additionally, the high prevalence of undiagnosed pre-existing diabetes should be noted.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
