期刊
ORGANIC CHEMISTRY FRONTIERS
卷 1, 期 2, 页码 148-150出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3qo00045a
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资金
- Singapore National Research Foundation (NRF)
- Singapore Economic Development Board (EDB)
- GlaxoSmithKline (GSK)
- Nanyang Technological University (NTU)
- National Research Foundation [NRF-CRP4-2008-02]
Facile access to trisubstituted pyridines from alpha-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.
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