期刊
CENTRAL EUROPEAN JOURNAL OF BIOLOGY
卷 4, 期 4, 页码 434-451出版社
SCIENDO
DOI: 10.2478/s11535-009-0056-7
关键词
PAMAM dendrimers; Cytotoxicity; Surface modifications; Non-enzymatic glycosylation; Mitochondrial function; Streptozotocin diabetes
类别
资金
- Ministry of Science and Higher Education [N401001236]
In this mini-review a number of novel outcomes, originating from studies in the field of PAMAM dendrimers, are presented and discussed. Owing to the multi-disciplinary nature of dendrimer chemistry it seems important to focus on the relevant topical research of PAMAM dendrimers, including their function, toxicity, surface modifications, and also possible new applications of these spherical polymers. We also consider the possibilities of specific functionalisation of PAMAM dendrimers - both novel ideas and those that have already been reported; as well as their cell-mediated effects (toxic and non-toxic). Then the reactivity of dendrimers' terminal groups, and their anticipated protective role against modifications of biomacromolecules, are discussed with regard to future developments in biomedical research.
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