期刊
OPEN CHEMISTRY
卷 13, 期 1, 页码 606-613出版社
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/chem-2015-0071
关键词
human monocytes; MAPK signaling; non-thermal plasma; plasma medicine; wound healing
资金
- German Ministry of Education and Research (BMBF) [03Z2DN11, 03Z2DN12]
The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.
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