期刊
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
卷 10, 期 4, 页码 1310-1317出版社
VERSITA
DOI: 10.2478/s11532-012-0056-8
关键词
Metoclopramide; Differential pulse voltammetry; Flow injection analysis; Boron-doped diamond film electrode; Passivation
资金
- Czech Ministry of Education, Youth and Sports [MSM 0021620857]
- Charles University in Prague [SVV 2012-265201, UNCE 2012/44]
- Grant Agency of the Czech Republic [P206/12/G151]
- Technology Agency of the Czech Republic [TA01020565]
New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 mu mol L-1 and 0.015 mmol L-1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.
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