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Secretory pathways generating immunosuppressive NKG2D ligands New targets for therapeutic intervention

ONCOIMMUNOLOGY (2014)

期刊

ONCOIMMUNOLOGY

卷 3, 期 4, 页码 -

出版社

LANDES BIOSCIENCE

DOI: 10.4161/onci.28497

关键词

NKs; NKG2D; soluble NKG2D ligands; shedding; exosomes

类别

Oncology Immunology

资金

Spanish grant from the Instituto de Salud Carlos III [PI12/02587]
Red de Investigacion Renal from the Instituto de Salud Carlos III [REDiNREN RD12/0021/0021]
European Union Fondos FEDER

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Protocol

Reagent

摘要

Natural Killer Group 2 member D (NKG2D) activating receptor, present on the surface of various immune cells, plays an important role in activating the anticancer immune response by their interaction with stress-inducible NKG2D ligands (NKG2DL) on transformed cells. However, cancer cells have developed numerous mechanisms to evade the immune system via the downregulation of NKG2DL from the cell surface, including the release of NKG2DL from the cell surface in a soluble form. Here, we review the mechanisms involved in the production of soluble NKG2DL (sNKG2DL) and the potential therapeutic strategies aiming to block the release of these immunosuppressive ligands. Therapeutically enabling the NKG2D-NKG2DL interaction would promote immunorecognition of malignant cells, thus abrogating disease progression.

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