期刊
ONCOIMMUNOLOGY
卷 3, 期 8, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.953423
关键词
inflammation; IL-17; myeloid-derived suppressor cells; tumor progression; gamma delta T cells
Chronic inflammation has been linked to cancer development and metastasis. We have recently demonstrated that gamma delta T cells are the major cellular source of IL-17 (gamma delta T17) and accumulation of gamma delta T17 cells correlates with human colorectal cancer progression through recruitment and expansion of myeloid-derived suppressor cells, thus converting tumor-elicited inflammation into immunosuppression.
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