期刊
ONCOIMMUNOLOGY
卷 3, 期 12, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.954853
关键词
antitumor immunity; innate immunity; interleukin 17D; natural killer cells; tumor rejection
资金
- NCI NIH HHS [R01 CA157885, K08 CA128893] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007198] Funding Source: Medline
Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.
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