Article
Biochemistry & Molecular Biology
Ken Woo, So Young Park, Andrew Padalhin, Hyun Seok Ryu, Celine DG. Abueva
Summary: This study investigated the effect of photobiomodulation (PBM) treatment on tonsil-derived mesenchymal stem cells (TMSCs) and its interaction with RAW 264.7 macrophage cells. The results showed that PBM priming improved the therapeutic efficacy of TMSCs and supported M2 macrophage polarization. Based on these findings, PBM can enhance the therapeutic efficacy of TMSCs for potential applications in oral mucositis and wound healing.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sree Samanvitha Kuppa, Hyung Keun Kim, Ju Yeon Kang, Seok Cheol Lee, Jong Keun Seon
Summary: Osteoarthritis is a low-grade inflammatory disorder of the joints, but there are limited treatment options currently available. This article explores the use of mesenchymal stem cells and their secreted factors for intervention in osteoarthritis, with a focus on the polarization of macrophages to reduce inflammation and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mariyam Kim, Laura Bakyt, Azamat Akhmetkaliyev, Dana Toktarkhanova, Denis Bulanin
Summary: Cancer stem cells (CSCs) are resistant to conventional chemotherapy and contribute to tumor relapse. Understanding the molecular mechanisms behind CSCs' chemoresistance is crucial for effective targeted therapy. Developmental signaling pathways, tumor microenvironment, epigenetic changes, and autophagy all play important roles in CSCs' chemoresistance development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yeong-In Yang, Yi-Yue Wang, Ji-Hye Ahn, Bo-Hyung Kim, Jung-Hye Choi
Summary: Tumor cells can develop resistance to paclitaxel by secreting large amounts of CCL2, which not only acts as an autocrine factor to induce chemoresistance, but also functions as a chemokine to attract macrophages, contributing to chemoresistance. Inhibiting the CCL2/CCR2 signaling axis may improve the therapeutic response of patients with ovarian cancer to paclitaxel.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang
Summary: The designed M2 macrophage microvesicle-inspired nanovehicle enhances accessibility to cancer cells and CSCs, effectively eliminating CSCs, inhibiting tumor growth, and suppressing lung metastasis. This strategy provides a promising approach for effective cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Medicine, Research & Experimental
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Summary: The study revealed that EZH2 plays a critical role in ovarian cancer stemness and chemo-resistance, with CHK1 being a target involved in CSC stemness regulated by EZH2. Clinical samples showed that high levels of EZH2 and CHK1 were associated with poorer prognosis and increased resistance to platinum drugs in ovarian cancer patients.
Review
Biochemistry & Molecular Biology
Kuo-Shyang Jeng, Chiung-Fang Chang, I-Shyang Sheen, Chi-Juei Jeng, Chih-Hsuan Wang
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Cancer stem cells (CSCs) in HCC play essential roles in tumor progression, resistance to therapy, and metastasis. Several surface markers, including EpCAM, CD90, CD44, and CD133, are used to identify liver CSCs, and multiple molecular signaling pathways, such as Wnt/beta-catenin, TGF-beta, SHH, PI3K/Akt/mTOR, and Notch, are implicated. Different markers are associated with poor prognosis, advanced tumor stages, early metastasis, and increased recurrence rate. Targeting CSCs and reducing their population is crucial for improving the treatment of advanced HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Haerdtner
Summary: The study provides genetic evidence that selectively altering macrophage polarization induces a stable plaque phenotype in mice. Specific deletion of IRF5 in myeloid cells showed protective effects against atherosclerosis by altering plaque composition and reducing inflammatory gene expression. Though the plaque size was not reduced, the study suggests a potential therapeutic target in modulating macrophage function to stabilize atherosclerotic plaques.
MOLECULAR METABOLISM
(2021)
Article
Oncology
Pengfei Su, Lin Jiang, Yingjing Zhang, Tian Yu, Weiming Kang, Yuqin Liu, Jianchun Yu
Summary: This study found that tumor-associated macrophages (TAMs) play an important role in chemoresistance in gastric cancer. Gastric cancer cells induce polarization of TAMs, leading to increased resistance to chemotherapy. Additionally, the protein CXCL5 produced by TAMs promotes chemoresistance by activating the PI3K/AKT/mTOR pathway. These findings have important implications for the treatment strategies of gastric cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xu Han, Minghui Li, Jin Xu, Jingyue Fu, Xinyang Wang, Jingyi Wang, Tiansong Xia, Shui Wang, Ge Ma
Summary: This study found that the expression level of miR-1275 is decreased in chemoresistant breast cancer, and low levels of miR-1275 are associated with poor overall survival. Knocking out miR-1275 increases chemoresistance in breast cancer cells by increasing cancer stem cell properties. miR-1275 could serve as a prognostic biomarker and therapeutic target for breast cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Athanasios Patsalias, Zuzana Kozovska
Summary: The study examines the potential of stem cells in cancer treatment, particularly in colorectal cancer. Stem cells can serve as biomarkers, facilitate personalized treatment, and guide the development of targeted therapies. The review suggests that stem cells offer dynamic potential for improving current treatment approaches and enhancing outcomes for cancer patients, specifically in CRC.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Takeshi Utsunomiya, Ning Zhang, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Claire Rhee, Ejun Huang, Zhenyu Yao, Stuart B. Goodman
Summary: The local injection of MSCs or pMSCs during the chronic inflammatory phase can reverse decreased bone mineral density and increased osteoclast-like cells, while immediate injection of pMSCs during the acute inflammatory phase may impair bone healing. Timing of interventions to modulate inflammation is critical for bone healing outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Vahideh Keyvani, Espanta Riahi, Meysam Yousefi, Seyed-Alireza Esmaeili, Rana Shafabakhsh, Amin Moradi Hasan-Abad, Maryam Mahjoubin-Tehran, Michael R. Hamblin, Samaneh Mollazadeh, Hamed Mirzaei
Summary: This article discusses the molecular mechanism of gynecologic cancer and the role of cancer stem cells (CSCs) in treatment, aiming to discover more specific therapeutic approaches to gynecologic cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
