期刊
ONCOIMMUNOLOGY
卷 3, 期 5, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.28811
关键词
aptamers; T cell memory; 4-1BB costimulation; mTOR; Tumor immunity
资金
- NCI NIH HHS [R01 CA181598] Funding Source: Medline
Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin ( mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
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