The dual role of IRF8 in cancer immunosurveillance

For a long time, the transcription factor interferon-regulatory factor 8(IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its fundamental relevance in multiple aspects of cancer immunosurveillance.