Article
Immunology
Xiaopei Cui, Chun-Guang Li, Haiqing Gao, Mei Cheng, Fan Jiang
Summary: Regulatory T cells (Tregs) play critical roles in immune balance and anti-inflammatory responses. Recent studies have shown that CX-5461 can promote Treg differentiation and prevent allogeneic acute rejection through a unique molecular mechanism. These findings suggest a potential role of p53 in mediating Treg differentiation and regulating Treg function through various mechanisms. Pharmacological p53 activators may offer new possibilities for enhancing Treg-mediated immune tolerance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Benjamin Jean Gaborit, Tanguy Chaumette, Marie Chauveau, Antoine Asquier-Khati, Antoine Roquilly, David Boutoille, Regis Josien, Benoit L. Salomon, Karim Asehnoune
Summary: The study found that CTLA4 expression and suppressive function were increased in circulating TNFR2(pos) Treg cells in patients with septic shock, suggesting the potential of TNFR2(pos) Treg cells as a target for therapeutic intervention.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Naomi Benne, Danielle ter Braake, Arie Jan Stoppelenburg, Femke Broere
Summary: This article discusses the strategy of using nanoparticles to deliver antigens and restore immune tolerance. It highlights potential cell targets and application methods for nanoparticles, as well as how nanoparticles carrying immunomodulators can activate tolerance in other antigen-presenting cell types. It also emphasizes the importance of considering relevant factors when translating animal studies to clinical applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Magis Mandapathil, Miroslaw J. Szczepanski, Edwin K. Jackson, Stephan Lang, Theresa L. Whiteside
Summary: The study suggests that breast cancer cells producing ADO are conducive to the induction of Tr1 cells, which exhibit higher immunosuppressive activity. Inhibiting ectonucleotidases and A2A receptors can reduce the proliferative suppression mediated by Tr1 cells.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Isabelle Serr, Felix Drost, Benjamin Schubert, Carolin Daniel
Summary: This review discusses the potential and challenges of antigen-specific Treg therapies in allergy and autoimmune diseases, with a focus on type 1 diabetes. It also highlights recent advances in miRNA-targeting and computational strategies for promoting Tregs and analyzing tissue-specific Tregs at the single-cell level.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shengliang Zhang, Lindsey Carlsen, Liz Hernandez Borrero, Attila A. Seyhan, Xiaobing Tian, Wafik S. El-Deiry
Summary: This article summarizes the current progress in targeting wild-type and mutant p53 for cancer therapy using biotherapeutic and biopharmaceutical methods. Strategies include boosting p53 activity, restoring p53 pathway function, targeting p53 in immunotherapy, and combination therapies.
Article
Multidisciplinary Sciences
Hee Su Sohn, Jeong Won Choi, JooYeon Jhun, Sung Pil Kwon, Mungyo Jung, Sangmin Yong, Hyun Sik Na, Jin-Hong Kim, Mi-La Cho, Byung-Soo Kim
Summary: This study describes an immunomodulating nanoparticle for the treatment of osteoarthritis. Injecting these nanoparticles into the joints of mice effectively suppressed inflammation, reduced inflammatory cells and cytokines, and improved the condition of chondrocytes, leading to pain relief.
Review
Immunology
Edgar Angelats, Pere Santamaria
Summary: TR1 cells are an immunosuppressive T cell subset that produces high levels of IL-10. Recent studies suggest that TR1 cells have potential therapeutic applications in immune-mediated diseases. However, the developmental biology of TR1 cells remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiawei Huang, Kai Xu, Linling Yu, Yunqiu Pu, Tong Wang, Rongli Sun, Geyu Liang, Lihong Yin, Juan Zhang, Yuepu Pu
Summary: Benzene is a typical hematopoietic toxic substance that affects the immune system, particularly T helper cell subsets. The study showed that Treg cells and secreted IL-10 may play a key role in immunosuppression in benzene-induced hematopoietic toxicity model mice.
Article
Pharmacology & Pharmacy
Qiji Li, Min Wang, Leli Zeng, Wei Guo, Yuandong Xu, Chenxin Li, Yingrong Lai, Liping Ye, Xinsheng Peng
Summary: The study found that wild-type p53 can suppress the metastasis of prostate cancer cells to bones by regulating the CXCR4/CXCL12 activity in the tumor cells/bone marrow microenvironment interactions. Targeting the wt-p53/AIP4/CXCR4 axis might be a promising therapeutic strategy to manage prostate cancer bone metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Kohei Araishi, Tomoko Shima, Ippei Yasuda, Sayaka Tsuda, Keiko Morita, Akemi Yamaki-Ushijima, Akitoshi Nakashima, Shigeru Saito
Summary: This study compared the variations in paternal antigen-specific regulatory T (PA-Treg) cells between the feto-maternal interface and the spleen, and elucidated the dynamics of naturally occurring Treg (nTreg) cells and peripherally induced Treg (iTreg) cells during the gestational period. The results showed that Nrp1+ nTreg cells induced PA immune tolerance in early pregnancy, while Nrp1- Treg cells played a dominant role in late pregnancy.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hong Yu, Hong-ying Gao, Hua Guo, Gui-zhen Wang, Yi-qing Yang, Qian Hu, Li-jun Liang, Qun Zhao, Da-wei Xie, Yu Rao, Guang-biao Zhou
Summary: RYL-687 inhibits non-small cell lung cancer cells by upregulating p53, which is achieved by inducing reactive oxygen species and upregulating NQO1 to protect p53 from degradation. Targeting NQO1 is a rational strategy to reactivate p53 and RYL-687 has therapeutic potentials in NSCLCs with wild type p53.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Engineering, Multidisciplinary
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Summary: Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that redirect cells to specific targets. They have been shown to improve accuracy, potency, and reduce off-target effects in cancer therapy. Regulatory T cells (Tregs) are important in suppressing immune activation and regulating the immune response. CAR-Tregs hold potential for treating autoimmune diseases, GVHD, and organ transplant rejection.
Review
Cell Biology
Elena Butturini, Giovanna Butera, Raffaella Pacchiana, Alessandra Carcereri de Prati, Sofia Mariotto, Massimo Donadelli
Summary: The wild-type p53 protein plays a crucial role in controlling cell growth to prevent neoplasm formation, but missense mutations in the TP53 gene can lead to structural and functional changes in the protein in more than half of all cancers. This dual role also extends to the regulation of the cell's redox state. Therapeutic opportunities targeting cysteines offer potential for modifying the structure and function of p53 mutant isoforms for anticancer treatments.
Article
Cardiac & Cardiovascular Systems
Alexis Slama, Mohamed Zaatar, Muhittin Demir, Oezlem Okumus, Stefan Mattheis, Sandra Kampe, Kaid Darwiche, Stephan Lang, Clemens Aigner
Summary: The study found that in carefully selected patients, tracheal or laryngotracheal resection after previous interventions provides comparable outcomes to primary surgery.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Oncology
Sharareh Bordbari, Britta Morchen, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Maksim Domnich, Freya Droege, Oliver Kanaan, Karl Sebastian Lang, Dirk Schadendorf, Stephan Lang, Iris Helfrich, Jadwiga Jablonska
Summary: This study reveals that Type I interferon-deficient tumor-associated neutrophils play a significant role in promoting angiogenesis in tumors by releasing pro-angiogenic factors and activating the transcription factor FOXO3a. The post-translational modifications of FOXO3a control its transcriptional activity, which ultimately regulates the expression of pro-angiogenic factors. Targeting FOXO3a activity could be a potential strategy for antiangiogenic targeted therapy in cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Irem Ozel, Inga Duerig, Maksim Domnich, Stephan Lang, Ekaterina Pylaeva, Jadwiga Jablonska
Summary: Tumor angiogenesis is a critical step in cancer progression, and neutrophils have been found to play an important role in this process. This review summarizes the pro-angiogenic functions of neutrophils and discusses the potential for targeting these cells in anti-cancer therapy.
Article
Multidisciplinary Sciences
Anna Wrobeln, Tristan Leu, Jadwiga Jablonska, Urban Geisthoff, Stephan Lang, Joachim Fandrey, Freya Droege
Summary: Patients with hereditary haemorrhagic telangiectasia (HHT) suffer from abnormal vessel structures, leading to vessel hemorrhage and shunt effects. This study found significantly decreased expression of HIF-1 alpha in HHT patients, with no effect on the known upstream regulators of HIF-1 alpha. The results highlight the importance of HIF in HHT and suggest an interaction between the known HHT mutation and HIF-1 alpha dysregulation in HHT patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Johannes Doescher, Moritz Meyer, Christoph Arolt, Alexander Quaas, Jens Peter Klussmann, Philipp Wolber, Agnes Bankfalvi, Hans-Ulrich Schildhaus, Tobias Bastian, Stephan Lang, Simon Laban, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Stephanie E. Weissinger
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor with late occurring metastases and recurrences. The lack of effective treatment in the palliative situation and unsuccessful trials on immunotherapeutic drugs show the need for prognostic markers and understanding the reasons for the lack of response to immunotherapy. The study found that ACC is not recognized by infiltrating immune cells, suggesting the need for other methods to induce recognition of ACC by the immune system. The low immunogenicity of ACC and the abundance of lymphocytes have no influence on prognosis, explaining the observed lack of response towards immunotherapy.
Article
Cell Biology
Jadwiga Jablonska, Malwina Rist, Ilona Spyra, Luisa Tengler, Maksim Domnich, Benjamin Kansy, Bernd Giebel, Basant Kumar Thakur, Nicole Rotter, Stephan Lang, Sonja Ludwig
Summary: Head and Neck Cancers (HNCs) exhibit highly immunosuppressive properties, and small extracellular vesicles (sEVs) play a role in intercellular communication by carrying immunosuppressive proteins and inhibiting anti-tumor immune responses. This study evaluates immunosuppressive markers on sEVs from HNC patients at different disease stages and follow-up periods. The findings suggest that a combination of immunoregulatory markers should be used to monitor disease progression and therapy response in HNC.
Article
Otorhinolaryngology
L. C. Holtmann, E. Deuss, M. Meyer, F. Kaster, T. Bastian, M. C. Schleupner, E. Hagedorn, S. Lang, D. Arweiler-Harbeck
Summary: This study evaluated the accuracy of using photographs taken by patients to detect skin irritations or complications after cochlear implantation. The results showed that digital evaluators could reliably detect treatment-requiring conditions, indicating that digital photographic assessment could reduce in-person consultations.
COCHLEAR IMPLANTS INTERNATIONAL
(2022)
Article
Otorhinolaryngology
Timon Hussain, Kruthika Thangavelu, Cornelius Kurten, Lisa Galland, Benedikt Hoing, Eric Deuss, Stefan Mattheis, Stephan Lang, Cornelius Deuschl, Michael Forsting, Nils Doerner
Summary: The results show a considerable inaccuracy of clinical neck staging in all OPSCC patients, and these findings need to be taken into consideration during therapy planning. For p16-positive patients, these findings warrant attention in the context of therapy deintensification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Cell Biology
Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari, Elena Siakaeva, Irem Ozel, Maksim Domnich, Anthony Squire, Anja Hasenberg, Kruthika Thangavelu, Timon Hussain, Moritz Goetz, Karl S. Lang, Matthias Gunzer, Wiebke Hansen, Jan Buer, Agnes Bankfalvi, Stephan Lang, Jadwiga Jablonska
Summary: In this study, researchers found that tumor-associated neutrophils migrate to lymph nodes during head and neck cancer progression and play a dual role in shaping anti-tumor responses. In metastasis-free stages, neutrophils stimulate T cells, while in metastatic stages, they suppress T cell responses. The accumulation of neutrophils in lymph nodes can predict the survival rate of head and neck cancer patients.
Article
Immunology
Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Irem Ozel, Freya Droege, Anthony Squire, Stefan Lienenklaus, Kathrin Sutter, Anja Hasenberg, Matthias Gunzer, Stephan Lang, Jadwiga Jablonska
Summary: Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of cancer occurs, and myeloid cells such as neutrophils play a crucial role in the activation of effector lymphocytes. The availability of type I interferon (IFN) influences the tumor-supportive or tumor-inhibiting activity of neutrophils. Defective type I IFN signaling leads to an impaired immunoregulatory capacity of neutrophils, resulting in enhanced tumor growth. Stimulation of IFN signaling may provide a therapeutic opportunity in head and neck cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Laura Christine Holtmann, Amadea Strahlenbach, Stefan Hans, Stephan Lang, Diana Arweiler-Harbeck
Summary: The medial olivocochlear reflex (MOCR) may affect bimodal hearing in some individuals, but it is not observable in all cases. Threshold changes observed in acoustic brainstem response (ABR) measurements were reproducible in a specific subgroup, potentially due to a reactivated MOCR.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Article
Otorhinolaryngology
Benedikt Hoeing, L. Wittig, L. Weber, B. A. Stuck, S. Mattheis, T. Hussain, S. Lang, J. M. Theysohn, Y. Li, S. Hansen
Summary: This retrospective study aimed to investigate the use of abdominal ultrasound as a staging procedure in head and neck squamous cell carcinoma (HNSCC). Out of 426 patients who received abdominal ultrasound, 7% were suspected of metastasis, with the majority being liver masses. The study found that abdominal ultrasound had a negative predictive value of 99.03% and a positive predictive value of 5.88% in HNSCC patients with N2/N3 cervical lymph node status.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Eric Deuss, Saskia Schieder, Stephan Lang, Stefan Mattheis, Orlando Guntinas-Lichius, Moritz Friedo Meyer
Summary: This survey aimed to assess the diagnostic workup and therapeutic strategies for salivary gland diseases in German otorhinolaryngology departments. The results showed diversity in the diagnosis and treatment methods, with variations in different locations.
Meeting Abstract
Immunology
E. Pylaeva, I. Spyra, I. Oezel, M. Domnich, B. Hoeing, C. Haist, H. Hanenberg, S. Lang, J. Jablonska
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
M. Pogorzelski, W. Fendler, C. Berliner, T. Hussain, S. Lang, S. Ting, K. W. Schmid, H. -U. Schildhaus, T. Gauler, M. Stuschke, K. Laue, K. Herrmann, V. Gruenwald, M. Schuler, S. Kasper-Virchow
ONCOLOGY RESEARCH AND TREATMENT
(2022)