期刊
ONCOIMMUNOLOGY
卷 2, 期 4, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.23621
关键词
adoptive immunotherapy; CD22; leukemia; ALL; retroviral vectors
CD22 is an attractive target for the development of immunotherapeutic approaches for the therapy of B-cell malignancies. In particular, an m971 antibody-derived, second generation chimeric antigen receptor (CAR) that targets CD22 holds significant therapeutic promise. The key aspect for the development of such a highly-active CAR was its ability to target a membrane-proximal epitope of CD22.
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