TGFβ1 microenvironment determines dendritic cell development

We have recently described two types of Langerhans cells (LCs), which develop via separate pathways in steady-state conditions and during inflammation. Here, we propose that these two types of LCs differ in their requirement for transforming growth factor 1 (TGF1), and we discuss how TGF1 impacts on the development of other dendritic cell subtypes.