Role of plasmacytoid dendritic cells in breast cancer bone dissemination

Elevated levels of plasmacytoid dendritic cells (pDC) have been observed as breast cancer disseminates to the bone. The selective depletion of pDC in mice led to a total abrogation of bone metastasis as well as to an increase in T(H)1 antitumor response, suggesting that pDC may be considered as a potential therapeutic target for metastatic breast cancer.