期刊
ONCOIMMUNOLOGY
卷 2, 期 12, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.26663
关键词
DNAM-1; multiple myeloma; NK cells; NKG2D; tumor immunology
Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on the surface of cancer cells, endowing them with the capacity to activate potent antitumor natural killer-cell responses.
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