Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: Lysophosphatidic acid receptors (LPARs) play a role in promoting tumorigenesis and therapy resistance in various cancer subtypes. Our study found that increased expression of LPAR1, LPAR4, and LPAR6 correlated with a less aggressive phenotype, while high expression of LPAR2 was associated with increased tumor grade, mutational burden, and decreased survival. Different LPARs were also expressed in different cell types, suggesting potential compensatory signaling in LPAR inhibitor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sayra Dilmac, Nilay Kuscu, Ayse Caner, Sendegul Yildirim, Burcak Yoldas, Ammad Ahmad Farooqi, Gamze Tanriover
Summary: This study investigated the roles of SIRT and FoxO proteins in breast cancer metastasis and found that SIRT1 co-operates with FoxO proteins and plays a critical role in metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maria Papatsirou, Pinelopi Artemaki, Paraskevi Karousi, Andreas Scorilas, Christos K. Kontos
Summary: Signal transduction is crucial for regulating fundamental cellular processes, and circRNAs are emerging as a type of endogenous transcripts with regulatory roles in various diseases, including cancer. Aberrantly expressed circRNAs can mediate cancer progression by impacting the activity of major signaling cascades.
Article
Chemistry, Multidisciplinary
Qiqi Liu, Hefen Sun, Yang Liu, Xuan Li, Baojin Xu, Liangdong Li, Wei Jin
Summary: The study reveals that 5-hydroxytryptamine receptor 1A (HTR1A) has anti-tumor potential in breast cancer by inhibiting the TGF-β pathway. HTR1A is also identified as an independent predictive factor for breast cancer patients, providing a new approach for the treatment of triple-negative breast cancer.
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Jolanta Smok-Kalwat, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Aleksandra Kozinska, Filip Koszalka, Wojciech Kwasniewski, Ewelina Grywalska, Stanislaw Gozdz
Summary: Lung cancer is a major threat to modern society, with increasing numbers of new cases and deaths each year. Despite extensive research, the mechanisms of lung cancer development and progression, particularly the role of the immune system, remain unclear. This literature review emphasizes the importance of immune system disorders and cell signaling changes in the pathogenesis of lung cancer. It suggests that future studies should focus on analyzing tumor microenvironmental immune checkpoints and genetic susceptibilities to lung cancer, which may lead to the development of personalized therapies and improved prognoses for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: The lipid phosphate phosphatases (LPPs) are enzymes that regulate signaling in cells. Imbalance of LPP expression levels, with decreased LPP1/3 and increased LPP2, is associated with worse tumor biology, immune system evasion, and decreased survival in breast cancers. Most tumor LPP1/3 is produced by the stroma and LPP2 by cancer cells. Restoring the balance in LPP expression levels, particularly through LPP2 inhibition, could provide adjunct therapies for breast cancer patients.
Article
Oncology
Yang Li, Jun Cao, Jianfeng Wang, Weidong Wu, Liren Jiang, Xing Sun
Summary: This study found that IGF2BP3 plays an important role in the progression and distant metastasis of breast cancer and is closely associated with brain metastasis. Positive IGF2BP3 expression is related to decreased distant metastasis-free survival and the occurrence of brain metastasis in breast cancer patients. High IGF2BP3 expression is associated with the PD-1 checkpoint pathway, HER2-HER3 signaling, and epithelial-mesenchymal transition.
Review
Oncology
Syazalina Zahari, Saiful Effendi Syafruddin, M. Aiman Mohtar
Summary: Breast cancer is a complex and challenging disease. The secretome, which includes proteins, lipids, and nucleic acids secreted by breast cancer cells, plays a crucial role in the development, progression, and drug resistance of breast cancer. Understanding the role of the secretome is essential for developing innovative therapies. This review explores the impact of the secretome on breast cancer progression and its interactions with the tumor microenvironment, and identifies potential therapeutic opportunities.
Article
Biochemistry & Molecular Biology
Shiro Uchida, Takashi Sugino
Summary: This study identified genes associated with breast cancer progression mechanisms and potential therapeutic targets using bioinformatic tools. It found several genes involved in breast cancer progression and identified potential novel therapeutic targets.
Article
Oncology
Shao-Ying Yang, Yi-Fan Xie, Tai-Mei Zhang, Ling Deng, Li Liao, Shu-Yuan Hu, Yin-Ling Zhang, Fang-Lin Zhang, Da-Qiang Li
Summary: This study reports the upregulation of IMPA1 in TNBC and its role in proliferation, metastasis and tumor formation in TNBC cells. Transcriptome sequencing analysis reveals that IMPA1 induces mTOR activity and epithelial-mesenchymal transition (EMT) process, thus promoting TNBC progression.
Article
Biochemistry & Molecular Biology
Meicen Zhou, Wenbao Lu, Bingwei Li, Xiaochen Yuan, Mingming Liu, Jianqun Han, Xueting Liu, Ailing Li
Summary: Roquin2 is identified as a novel breast cancer suppressor that inhibits tumor angiogenesis by selectively downregulating the expression of proangiogenic genes. Overexpression of Roquin2 can inhibit breast tumor-induced angiogenesis, while silencing Roquin2 enhances tumor angiogenesis. In vivo induction of Roquin2 significantly suppresses breast tumor growth, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Shivashankar Pranavkrishna, Ganesh Sanjeev, Ravishkumar L. Akshaya, Muthukumar Rohini, Nagarajan Selvamurugan
Summary: Breast cancer is a major threat among women globally, with bone metastasis being extensively studied. Research has shown the crucial role of miRNAs in targeting Runx2 during this process.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qi Shang, Shiyao Zhou, Zijia Zhou, Yue Jiang, Yuxia Luan
Summary: Targeting breast cancer stem cells (BCSCs) therapy is a promising strategy to eliminate tumors by remolding the disequilibrium state and blocking the EMT process, demonstrating a potential photodynamic platform against tumor progression and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)