Article
Oncology
Dandan Sheng, Wei Ma, Rui Zhang, Lei Zhou, Qiaodan Deng, Juchuanli Tu, Weilong Chen, Fuchuang Zhang, Nailong Gao, Mengxue Dong, Dong Wang, Fengkai Li, Yin Liu, Xueyan He, Shengzhong Duan, Lixing Zhang, Tong Liu, Suling Liu
Summary: Our study reveals that DTX-induced CCL3 triggers proinflammatory macrophage polarization and facilitates phagocytosis of cancer cells. CCL3 induction in combination with DTX may provide a promising therapeutic rationale for increasing DTX chemosensitivity in breast cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Juan Manuel Ortiz Wilczynski, Hebe Agustina Mena, Martin Manuel Ledesma, Cinthia Mariel Olexen, Enrique Podaza, Mirta Schattner, Soledad Negrotto, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Summary: Monocytes are plastic cells that differentiate into macrophages and play a crucial role in inflammation resolution and tissue regeneration. They exhibit dynamic switching from pro-inflammatory to pro-reparative phenotypes depending on the wound environment. Promoting tissue repair program switching is a promising strategy for chronic inflammatory wounds.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jiaojiao Chen, Xuying Xiang, Lei Nie, Xiaoqing Guo, Feng Zhang, Cheng Wen, Yuanpeng Xia, Ling Mao
Summary: Atherosclerosis is a chronic inflammatory disease of artery walls, and the molecular mechanisms involved are still unclear. T cells, especially Th1 cells, have been recognized as important mediators in the pathogenesis of atherosclerosis. This review aims to summarize the role of Th1 cells in atherosclerosis and propose potential preventative and therapeutic approaches targeting specific cytokines and receptors associated with Th1 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takaki Tominaga, Jiapeng Huang, Shuo Wang, Miwa Noguchi, Yishan Tong, Momoko Asano-Oritani, Katsuhiko Suzuki
Summary: Several food components, including polyphenols and phytonutrients, have immunomodulatory effects. Collagen, known for its various bioactivities, can promote wound healing and relieve symptoms of bone/joint disease. This study investigated the immunomodulatory effects of collagen-derived dipeptides and amino acids on macrophages and peripheral blood mononuclear cells (PBMC), and found that there is no difference in cytokine secretion between dipeptides and amino acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xibao Zhao, Qianqian Di, Han Liu, Jiazheng Quan, Jing Ling, Zizhao Zhao, Yue Xiao, Han Wu, Zherui Wu, Wengang Song, Huazhang An, Weilin Chen
Summary: This study demonstrates the critical role of MEF2C in regulating macrophage polarization, with involvement in inflammation and host defense through promoting the expression of interleukin-12. MEF2C deficiency leads to increased susceptibility to certain infections and protection against certain intestinal diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Erik Martens, Bert Malengier-Devlies, Jennifer Vandooren, Jan Jeroen Vranckx, Patrick Matthys, Ghislain Opdenakker
Summary: This study found that using physiological fibrin hydrogels in skin wound healing in mice can modulate immune cells and molecules, leading to faster wound repair. The hydrogels can reduce neutrophil numbers, increase non-classical Ly6Clow monocytes and resolutive macrophage populations, and decrease the expression of pro-inflammatory cytokines. Additionally, the hydrogels can increase the counts of dermal endothelial cells, fibroblasts, and keratinocytes, promote keratinocyte migration, and accelerate wound healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Abdullah M. Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M. Ali Zainy, Bilal Rah
Summary: This study evaluates the anti-inflammatory and immunomodulatory effects of Withaferin A (WA) in immune cells extracted from BALB/c mice. The results show that WA exhibits anti-inflammatory and immunomodulatory activity by modulating inflammatory signaling pathways and reducing the expression of proinflammatory cytokines.
Article
Cell Biology
Dante Barreda, Cesar Santiago, Juan R. Rodriguez, Jose F. Rodriguez, Jose M. Casasnovas, Isabel Merida, Antonia Avila-Flores
Summary: Dendritic cells play a crucial role in the clinical evolution of SARS-CoV-2 infection, as their interaction with the virus's Spike protein promotes inflammatory response and effective immunity, linking individual variations to the degree of response against the virus.
Article
Plant Sciences
Hamsalakshmi, Suresh Joghee, Sreeram P. Kalarikkal, Gopinath M. Sundaram, T. Durai Ananda Kumar, Saravana Babu Chidambaram
Summary: The study demonstrated the anti-inflammatory effects of extracts from the aerial parts of Trichodesma indicum, with fraction FE showing the strongest ability to reduce inflammatory cytokines without cytotoxicity. The major compound in FE, 1,2-benzenedicarboxylic acid diisooctyl ester, exhibited good inhibition against key inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Nan Song, Kaifeng Pan, Lei Chen, Keke Jin
Summary: The study found that nano-platelet vesicles can promote macrophage phenotype switching, thus promoting trauma repair and potentially playing a crucial role in certain inflammatory diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Ji Cheng Han, Qiu Xuan Li, Jin Bo Fang, Jin Yong Zhang, Yi Quan Li, Shan Zhi Li, Cheng Cheng, Chang Zhan Xie, Fu Long Nan, He Zhang, Zhuo Xin Li, Ning Yi Jin, Guang Ze Zhu, Hui Jun Lu
Summary: Norovirus is a zoonotic virus causing diarrhea in humans and animals, with the emergence of GII.P16-GII.2 recombinant genotype posing a potential pandemic threat. Immunization with VLPs induced specific cellular and humoral responses in mice, revealing the antigen presentation mechanism and providing insights for vaccine development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bingqing Shi, Yuqiu Hao, Wei Li, Hongna Dong, Mengting Xu, Peng Gao
Summary: TIPE2 plays different roles in different asthma inflammatory phenotypes and inhibits neutrophilic inflammation by targeting the Nrf2/HO-1 pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tatiana V. V. Kirichenko, Yuliya V. V. Markina, Anastasia I. I. Bogatyreva, Taisiya V. V. Tolstik, Yurgita R. R. Varaeva, Antonina V. V. Starodubova
Summary: This article reviews the key functions of adipokines in the inflammatory mechanisms, complications, and associated diseases of obesity. Through an extensive search on the role of adipokines in the pathogenesis of obesity, existing research findings are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Astri Frafjord, Renate Skarshaug, Clara Hammarstrom, Branislava Stankovic, Linda T. Dorg, Henrik Aamodt, Per Reidar Woldbaek, Aslaug Helland, Odd Terje Brustugun, Inger Oynebraten, Alexandre Corthay
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Branislava Stankovic, Henrik Aamodt, Heidi Anine Korsmo Bjorhovde, Elisabeth Mueller, Clara Hammarstrom, Odd Terje Brustugun, Aslaug Helland, Inger Oynebraten, Alexandre Corthay
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Matthew J. Frank, Michael S. Khodadoust, Debra K. Czerwinski, Ole A. W. Haabeth, Michael P. Chu, David B. Miklos, Ranjana H. Advani, Ash A. Alizadeh, Neel K. Gupta, Lauren S. Maeda, Sunil A. Reddy, Ginna G. Laport, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Wen-Kai Weng, Kevin Sheehan, Malek Faham, Ami Okada, A. Holliston Moore, Destiny L. Phillips, Irene L. Wapnir, Joshua D. Brody, Ronald Levy
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Hematology
Ole Audun W. Haabeth, Kjartan Hennig, Marte Fauskanger, Geir Age Loset, Bjarne Bogen, Anders Tveita
Article
Biology
Jo Waaler, Line Mygland, Anders Tveita, Martin Frank Strand, Nina Therese Solberg, Petter Angell Olsen, Aleksandra Aizenshtadt, Marte Fauskanger, Kaja Lund, Shoshy Alam Brinch, Max Lycke, Elisabeth Dybing, Vegard Nygaard, Sigurd Laeines Boe, Karen-Marie Heintz, Eivind Hovig, Clara Hammarstrom, Alexandre Corthay, Stefan Krauss
COMMUNICATIONS BIOLOGY
(2020)
Article
Hematology
Aaron J. Wilk, Nancy Lynn-Benner Weidenbacher, Rosemary Vergara, Ole A. W. Haabeth, Ronald Levy, Robert M. Waymouth, Paul A. Wender, Catherine A. Blish
Biographical-Item
Immunology
Peter Bretscher, Alexandre Corthay, Zlatko Dembic, Hans-Georg Rammensee
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Alexandre Corthay, Tibor Bakacs, Govindarajan Thangavelu, Colin C. Anderson
Summary: The major challenge in cancer treatment is dealing with disseminated dormant cancer cells and the balance with the immune system. Various competing models of how the immune system achieves self nonself discrimination are discussed, and it is suggested that a combination of mechanisms from each model may enhance the efficacy in tackling cancer cell dormancy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ole A. W. Haabeth, Julian J. K. Lohmeyer, Adrienne Sallets, Timothy R. Blake, Idit Sagiv-Barfi, Debra K. Czerwinski, Blaine McCarthy, Abigail E. Powell, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Summary: The success of two FDA-approved mRNA vaccines in combating the SARS-CoV-2 pandemic has demonstrated the speed and therapeutic potential of mRNA vaccines. To ensure flexibility in future vaccine development, different vaccination strategies and alternative mRNA delivery vehicles are desirable.
ACS CENTRAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Panagiotis F. Christopoulos, Mantas Grigalavicius, Alexandre Corthay, Kristian Berg, Theodossis A. Theodossiou
Summary: Excessive secretion of nitric oxide interferes with oxygen consumption measurements in macrophages, impacting accurate metabolic characterization. Inhibition of nitric oxide production partially restores respiration in activated macrophages, highlighting the importance of controlling reactive nitrogen species in cellular metabolic studies.
Editorial Material
Immunology
Alexandre Corthay, Petter Hoglund
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefano Testa, Ole A. W. Haabeth, Timothy R. Blake, Trevor J. Del Castillo, Debra K. Czerwinski, Ranjani Rajapaksa, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Summary: Charge-altering releasable transporters (CARTs) containing fingolimod were synthesized to enhance mRNA delivery and expression in lymphocytes through ligand-receptor interaction. The fingolimod-conjugated CARTs showed superior transfection of activated T and B lymphocytes in vitro and increased mRNA delivery to specific cell populations in the spleen in vivo.
Meeting Abstract
Immunology
A. Frafjord, L. Buer, C. Hammarstrom, H. Aamodt, P. Woldbaek, O. Brustugun, A. Helland, I. Oynebraten, A. Corthay
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)